Angewandte Chemie, Volume 138, Issue 17, 20 April 2026.This study explores the origins of life by linking prebiotic chemistry, the emergence of information‐carrying molecules such as RNA and proteins, and philosophical questions about consciousness. The study emphasizes the role of molecular evolution in the Central Dogma and provides insights into the chemical origins of biology and the basis of life's ...
Harald Schwalbe +5 more
wiley +2 more sources
Mechanistic Insights Into the Retention and Separation Mechanism of Poly(Ethylene Glycol)-Modified Short Oligonucleotides in Anion-Exchange Chromatography. [PDF]
Biotechnol JYoshimoto N +3 more
europepmc +1 more source
GmSNAP14: a key contributor to soybean cyst nematode resistance in soybean
New Phytologist, Volume 250, Issue 4, Page 2477-2494, May 2026.Summary Soybean (Glycine max) plants counteract soybean cyst nematode (SCN, Heterodera glycines Ichinohe) infection through an impairment of soluble N‐ethylmaleimide‐sensitive factor (NSF) attachment protein (α‐SNAP) – NSF interactions and vesicular trafficking leading to cellular toxicity in response to nematode feeding.
Vinavi A. Gamage +9 more
wiley +1 more source
Visualizing and Quantifying microRNA‐Induced DNA Origami Separation at the Nanoscale
Angewandte Chemie, Volume 138, Issue 17, 20 April 2026.Clinically relevant miRNA biomarkers trigger the disassembly of DNA origami dimers into monomers through a toehold‐mediated strand displacement reaction. High‐speed AFM was used to visualize this reaction in real time, while solid‐state nanopore measurements quantified the populations of dimers and monomers, as well as the resulting miRNA concentration,
Chalmers C. C. Chau +4 more
wiley +2 more sources
Light-Mediated Supramolecular Functionalization of Polymerization-Induced Self-Assembled Micelles. [PDF]
SmallRossi R +5 more
europepmc +1 more source
Mechanistic Insights Into the Photosensitizing Properties of the Topical Retinoid Tazarotene
ChemMedChem, Volume 21, Issue 8, 28 April 2026.Light‐activated retinoids: Tazarotene and its active metabolite tazarotenic acid form long‐lived triplet excited states upon UVA irradiation, generating singlet oxygen and promoting photochemical reactions. These processes correlate with reduced fibroblast viability under light exposure, revealing potential phototoxicity and implications for combined ...
Juan A. Soler‐Orenes +5 more
wiley +1 more source
Thymine DNA glycosylase binds to R-loops and excises 5-formyl and 5-carboxyl cytosine from DNA/RNA hybrids. [PDF]
J Biol ChemZhu B +7 more
europepmc +1 more source
Synthesis and properties of l-<i>lyxo</i>-thioBsNA-pyrimidine nucleoside: a sulfur-containing analogue of boat-shaped pyranosyl nucleic acid. [PDF]
RSC Chem BiolIto M +4 more
europepmc +1 more source
Uncontrolled hypertension in siblings: an unsuspected diagnosis. [PDF]
AJOG Glob RepAleem S +3 more
europepmc +1 more source
Harnessing Methyltransferase‐Guided Targeting for Sequence‐Specific Proximity Labeling of DNA
Angewandte Chemie, Volume 138, Issue 15, 6 April 2026.A novel methyltransferase‐mediated approach leveraging rationally designed S‐adenosyl‐L‐methionine (SAM) analogues was developed to achieve sequence‐specific DNA labeling but in proximity to the natural transfer site, addressing key limitations of previously established methods, including ligand instability and methylation‐sensitive labeling.
Xiong Chen +8 more
wiley +2 more sources