Results 121 to 130 of about 106,654 (267)

Identification of MEF2A, MEF2C, and MEF2D interactomes in basal and Fsk‐stimulated mouse MA‐10 Leydig cells

Andrology, EarlyView.
Abstract Background Myocyte enhancer factor 2 transcription factors regulate essential transcriptional programs in various cell types. The activity of myocyte enhancer factor 2 factors is modulated through interactions with cofactors, chromatin remodelers, and other regulatory proteins, which are dependent on cell context and physiological state.
Karine de Mattos, Marie‐Pier Scott‐Boyer, Arnaud Droit, Robert S. Viger, Jacques J. Tremblay   +4 more
wiley   +1 more source

Contrasting effects of different molecular crowding environments on base‐pair opening/closing dynamics of DNA triplex structures

The FEBS Journal, EarlyView.
Base‐pair opening and closing regulate nucleic‐acid structure, stability, and function, but how these motions behave under intracellular molecular crowding remains unclear. Using NMR, we quantified these dynamics in a DNA triplex under two crowder‐reconstituted environments that mimic cellular crowding.
Tomoki Sakamoto, Yudai Yamaoki, Takashi Nagata, Masato Katahira   +3 more
wiley   +1 more source

Aptamer‐mediated outer membrane destabilization overcomes low permeability resistance in Pseudomonas aeruginosa

The FEBS Journal, EarlyView.
DNA aptamers, Apt 60 and Apt 173, target the BamA protein to compromise outer membrane integrity in Pseudomonas aeruginosa, making it susceptible to Azithromycin, an antibiotic that is otherwise poorly effective due to the low‐permeability membrane.
Rupany Selvam, Michelle Khai Khun Yap, Rafael Giacomazzi, Sérgio F. Sousa, Hock Siew Tan   +4 more
wiley   +1 more source

TNF‑α Gene Polymorphisms as Determinants of Alloantibody Emergence in Hemophilia: A Systematic Review and Meta‐Analysis

Haemophilia, EarlyView.
ABSTRACT Introduction Inhibitor development remains one of the most serious complications of replacement therapy in patients with hemophilia. Tumour necrosis factor‐alpha (TNF‐α) is a key pro‐inflammatory cytokine, and its genetic variants have been implicated in immune‐related conditions.
Alessandra Faustino da Conceição Bezerra, Natã Abner Andrade Carito de Sousa, Suely Meireles Rezende, Renan Pedra de Souza   +3 more
wiley   +1 more source

Alquilação seletiva na posição N1 de timina e uracil em sistema de Mitsunobu/Selective alkylation at the N1 position of thymine and uracil in the Mitsunobu system

Orbital: The Electronic Journal of Chemistry, 2010
Selectivity of alkylation at the N1 position in pyrimidines (thymine and uracil) was achieved by the application of N3-benzoyl thymine and N3-benzoyl uracil as substrates, where the N3 atom was temporarily protected, exposing the N1 atom as the ...
Fábio D. P. Soares, Edmilson C. de Siqueira, Sandra A. do Nascimento, Bogdan Doboszewski   +3 more
doaj  

The impact of accumulating immune adaptation in circulating strains of HIV‐1

HIV Medicine, EarlyView.
Abstract Background Mutations in human immunodeficiency virus type 1 (HIV‐1) enable the virus to evade recognition and killing by human leucocyte antigen (HLA)‐restricted T cells. These viral adaptations are specific to the HLA type of individuals and are therefore evident as HLA allele‐HIV sequence associations at the population level. Most studies of
Marwah Al‐kaabi, Alison Castley, Pooja Deshpande, Abha Chopra, David Nolan, Simon Mallal, Mina John, Silvana Gaudieri   +7 more
wiley   +1 more source

Integrative taxonomy reveals four new species of the armoured catfish genus Pareiorhina (Siluriformes: Loricariidae) from the upper Paraná River basin, Brazil

Journal of Fish Biology, EarlyView.
Abstract Four new species of the small‐sized armoured catfish genus Pareiorhina are described from mountain ranges in the Grande River drainage, upper Paraná River basin, based on morphological and molecular species delimitation methods. Molecular analyses based on the cytochrome oxidase subunit I (COI) marker recovered Pareiorhina as polyphyletic ...
Pedro L. C. Uzeda, Luana J. Sartori, Axel M. Katz, Felipe P. Ottoni, Wilson J. E. M. Costa, Francisco Langeani, Valter M. Azevedo‐Santos   +6 more
wiley   +1 more source

DNA barcoding and geometric morphometry of tabanid flies (Diptera: Tabanidae) in Thailand and a new record of a Thai horse fly

Medical and Veterinary Entomology, EarlyView.
Tabanus tenens identified in this study is a newly recorded species in Thailand. DNA barcoding using the cox1 gene identified tabanid species in the present study. WGM data from different sites served as a reference for species identification. Abstract Tabanid flies are gaining high medical and veterinary importance due to their role as a vector of ...
Nantatchaporn Klaiklueng, Weluga Bootsongkorn, Patsharaporn T. Sarasombath, Pichet Ruenchit, Sirichit Wongkamchai   +4 more
wiley   +1 more source

The complete mitochondrial genome of Sarcophaga angarosinica (Diptera: Sarcophagidae)

Mitochondrial DNA. Part B. Resources
Sarcophaga (Liosarcophaga) angarosinica (Rohdendorf, 1937) (Diptera: Sarcophagidae) is a species of both medical and ecological significance. In this study, the complete mitochondrial genome (mitogenome) of S. angarosinica was sequenced and characterized.
Ziqi Zhou, Zhiyun Pi, Yuanxing Wang, Shaojiang Guo, Nan Guo, Junbo Yang, Xiangyan Zhang, Changquan Zhang, Jifeng Cai   +8 more
doaj   +1 more source

VERNALIZATION2 alters early tiller development in a facultative spring hexaploid bread wheat

New Phytologist, EarlyView.
Summary An extended period of cold exposure enables the process of vernalization in winter cereals and is important for the synchronised timing of the floral transition. The cereal‐specific floral repressor VERNALIZATION2 (VRN2) has an integral role in vernalization, yet this locus remains poorly characterised in facultative spring hexaploid wheat ...
Dominique Hirsz, Harry Taylor, India Lacey, Wenxue Wu, Adam Gauley, Laura Dixon   +5 more
wiley   +1 more source