Results 111 to 120 of about 60,531 (292)
Utilising Uracil DNA Glycosylase to detect the presence of 5-Methylcytosine
, 2014 DNA is regularly subjected to endogenous and exogenous reagents that cause mutations that can be detrimental to a cell if they are not repaired. One class of enzymes responsible for DNA repair is the family of DNA glycosylases and their role is to remove
Kimber, Scott T.
core
White light emitting molecular logic gates
Smart Molecules, EarlyView.White light emitting smart molecules with Boolean logic computing ability are surveyed. Abstract White light emitting (WLE) materials are of considerable interest with commercial and societal applications in video displays and lighting devices. A characteristic property of WLE materials is the luminescence profile spanning from 380 to 700 nm.
Davide Benedetto Tiz +2 more
wiley +1 more source
Programmable DNA pyrimidine base editing via engineered uracil-DNA glycosylase
Nature CommunicationsDNA base editing technologies predominantly utilize engineered deaminases, limiting their ability to edit thymine and guanine directly. In this study, we successfully achieve base editing of both cytidine and thymine by leveraging the translesion DNA ...
Zongyi Yi +10 more
doaj +1 more source
Animal Conservation, EarlyView.Using fecal DNA metabarcoding, we quantified dietary overlap among reintroduced fishers and sympatric coyotes, bobcats, and Pacific martens in Washington's North Cascades. Niche overlap was substantial for common prey but varied with body size, revealing fine‐scale resource partitioning that may limit fishers' access to energetically efficient prey ...
Kayla A. Shively +7 more
wiley +1 more source
Ultrafast Deactivation Channel for Thymine Dimerization
, 2016 Intrastrand thymine dimerization is the dominant process leading to DNA photodamage after ultraviolet irradiation. However, the mechanism behind this photoreaction is not well understood. In this study, the mechanism for photoinduced thymine dimerization
Gerrit Groenhof (43936) +4 more
core +1 more source
Andrology, EarlyView.Abstract Background Myocyte enhancer factor 2 transcription factors regulate essential transcriptional programs in various cell types. The activity of myocyte enhancer factor 2 factors is modulated through interactions with cofactors, chromatin remodelers, and other regulatory proteins, which are dependent on cell context and physiological state.
Karine de Mattos +4 more
wiley +1 more source
Chemical structure of thymine labeled with fluorescent dyes.
, 2013 A : Thiazole pink-labeled thymine. B : Thiazole orange-labeled thymine.
Kimihiro Shimizu (397378) +18 more
core +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Genomic profiling of patients for genetic variants that modify the effect of specific medications has many benefits, including the possibility of avoiding toxicities and ensuring an adequate effect of the medication. Our intention was to develop a comprehensive, high‐quality pharmacogenetic test panel for clinical use ...
Anna Gréen +5 more
wiley +1 more source
Structure of a DNA Glycosylase Bound to a Nicked T:G Mismatch-Containing DNA
MoleculesMismatched T:G base pairs can arise during de novo replication as well as base excision repair (BER). In particular, the action of the gap-filling polymerase β (Polβ) can generate a T:G pair as well as a nick in the DNA backbone.
Hala Ouzon-Shubeita +3 more
doaj +1 more source
The FEBS Journal, EarlyView.Base‐pair opening and closing regulate nucleic‐acid structure, stability, and function, but how these motions behave under intracellular molecular crowding remains unclear. Using NMR, we quantified these dynamics in a DNA triplex under two crowder‐reconstituted environments that mimic cellular crowding.
Tomoki Sakamoto +3 more
wiley +1 more source