Results 91 to 100 of about 65,072 (224)

Utilising Uracil DNA Glycosylase to detect the presence of 5-Methylcytosine

, 2014
DNA is regularly subjected to endogenous and exogenous reagents that cause mutations that can be detrimental to a cell if they are not repaired. One class of enzymes responsible for DNA repair is the family of DNA glycosylases and their role is to remove
Kimber, Scott T.
core   +1 more source

Electrosynthesis of PolyFilm Modified Graphite Electrode and its Application Towards Determination of Thymine [PDF]

Materials Research
This article presents an electrochemical sensor designed for the identification of thymine, one of the nitrogenous bases in deoxyribonucleic acid, crucial for diagnosing damage and health issues such as cancer.
M.P. Amaral, R.S. Babu, L.M. Samyn, A.L.F. de Barros   +3 more
doaj   +1 more source

Decay Pathways of Thymine Revisited

, 2018
The decay of electronically excited states of thymine (Thy) and thymidine 5′-monophosphate (TMP) was studied by time-resolved UV/vis and IR spectroscopy.
Wolfgang J. Schreier (1317468), Bert M. Pilles (1317477), Benjamin Maerz, Jinquan Chen, Wolfgang Zinth, Benjamin Maerz (3114789), Benjamin P. Fingerhut (1287117), Bern Kohler, Bern Kohler (1359810), Bert M. Pilles, Benjamin P. Fingerhut, Dominik B. Bucher, Peter Gilch (1317462), Wolfgang J. Schreier, Jinquan Chen (837183), Dominik B. Bucher (5244533), Wolfgang Zinth (1317471), Peter Gilch   +17 more
core   +1 more source

Nucleobase pairing and photodimerization in a biologically derived metal-organic framework nanoreactor

Nature Communications, 2019
Metal-organic frameworks have shown promise as nanoreactors, facilitating the synthesis of molecules that are otherwise difficult to isolate. Here, the authors design a framework featuring unobstructed adenine linkers to which thymine molecules can base ...
Samantha L. Anderson, Peter G. Boyd, Andrzej Gładysiak, Tu N. Nguyen, Robert G. Palgrave, Dominik Kubicki, Lyndon Emsley, Darren Bradshaw, Matthew J. Rosseinsky, Berend Smit, Kyriakos C. Stylianou   +10 more
doaj   +1 more source

Mercury^II-Mediated Formation of Thymine−Hg^II−Thymine Base Pairs in DNA Duplexes

, 2016
The very specific binding of the HgII ion unexpectedly and significantly stabilizes naturally occurring thymine−thymine base mispairing in DNA duplexes. Following this finding, we prepared DNA duplexes containing metal-mediated base pairs at the desired ...
Humika Togashi (2650075), Yoshiyuki Tanaka (1398277), Tomoya Machinami (2650066), Takashi Fujimoto (1655704), Ryuichi Sawa (827420), Shuji Oda (2509846), Hiroshi Yamaguchi (575651), Akira Ono (88774), Megumi Kudo (2650063), Yoshinori Kondo (1528870), Yoko Miyake (2650072), Mitsuru Tashiro (2650069)   +11 more
core   +1 more source

Thymines opposite to bulky aristolactam-DNA adducts in duplex DNA are not targeted by human thymine-DNA glycosylase [PDF]

PeerJ
Background Consumption of aristolochic acids (AA) from the plant Aristolochia results in the formation of bulky aristolactam-dA (dA-AL) and aristolactam-dG (dG-AL) adducts in cellular DNA ultimately leading to the development of urothelial cancer ...
Diana Manapkyzy, Gulzhan Zhamanbayeva, Viktoriya Sidorenko, Radha Bonala, Francis Johnson, Bakhyt T. Matkarimov, Dmitry Zharkov, Murat K. Saparbaev, Sabira Taipakova   +8 more
doaj   +2 more sources

Human thymine DNA glycosylase (TDG) and methyl‐CpG‐binding protein 4 (MBD4) excise thymine glycol (Tg) from a Tg:G mispair

, 2003
The repair enzymes thymine DNA glycosylase (TDG) and methyl-CpG-binding protein 4 (MBD4) remove thymines from T:G mismatches resulting from deamination of 5-methylcytosine.
Yoon, Jung‐Hoon, Iwai, Shigenori, Pfeifer, Gerd P, O’Connor, Timothy R   +3 more
core   +1 more source

Lack of Association Between Toll-like Receptor 2 Polymorphisms (R753Q and A-16934T) and Atopic Dermatitis in Children from Thrace Region of Turkey

Balkan Medical Journal, 2017
Background: Atopic dermatitis is the most common chronic inflammatory skin disease. A complex interaction of both genetic and environmental factors is thought to contribute to the disease. Aims: To evaluate whether single nucleotide polymorphisms in the
Ceren Can, Mehtap Yazıcıoğlu, Hakan Gürkan, Hilmi Tozkır, Adnan Görgülü, Necdet Hilmi Süt   +5 more
doaj   +1 more source

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Isolation of acetylcholinesterase gene from Egyptian Anopheles pharoensis (Theobald)

Journal of Basic and Applied Zoology, 2012
Acetylcholinesterase (ACE) is the target of two major insecticide families, organophosphates (OPS) and carbamates. Acetylcholinesterase is a frequent resistance mechanism in insects and responsible mutations were identified in many dipteran species.
Nahla M. Wassim
doaj   +1 more source