Results 81 to 90 of about 60,531 (292)

Electrosynthesis of PolyFilm Modified Graphite Electrode and its Application Towards Determination of Thymine [PDF]

Materials Research
This article presents an electrochemical sensor designed for the identification of thymine, one of the nitrogenous bases in deoxyribonucleic acid, crucial for diagnosing damage and health issues such as cancer.
M.P. Amaral, R.S. Babu, L.M. Samyn, A.L.F. de Barros   +3 more
doaj   +1 more source

Nucleobase pairing and photodimerization in a biologically derived metal-organic framework nanoreactor

Nature Communications, 2019
Metal-organic frameworks have shown promise as nanoreactors, facilitating the synthesis of molecules that are otherwise difficult to isolate. Here, the authors design a framework featuring unobstructed adenine linkers to which thymine molecules can base ...
Samantha L. Anderson, Peter G. Boyd, Andrzej Gładysiak, Tu N. Nguyen, Robert G. Palgrave, Dominik Kubicki, Lyndon Emsley, Darren Bradshaw, Matthew J. Rosseinsky, Berend Smit, Kyriakos C. Stylianou   +10 more
doaj   +1 more source

Mercury^II-Mediated Formation of Thymine−Hg^II−Thymine Base Pairs in DNA Duplexes

, 2016
The very specific binding of the HgII ion unexpectedly and significantly stabilizes naturally occurring thymine−thymine base mispairing in DNA duplexes. Following this finding, we prepared DNA duplexes containing metal-mediated base pairs at the desired ...
Humika Togashi (2650075), Yoshiyuki Tanaka (1398277), Tomoya Machinami (2650066), Takashi Fujimoto (1655704), Ryuichi Sawa (827420), Shuji Oda (2509846), Hiroshi Yamaguchi (575651), Akira Ono (88774), Megumi Kudo (2650063), Yoshinori Kondo (1528870), Yoko Miyake (2650072), Mitsuru Tashiro (2650069)   +11 more
core   +1 more source

Second‐trimester multimetabolite panel for early preeclampsia rule‐out

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective We aimed to establish a high‐sensitivity, multimetabolite rule‐out model for the development of preeclampsia (PE), prioritizing minimizing false negatives to exclude low‐risk individuals from intensive surveillance confidently. Methods In this prospective, nested case–control study, maternal serum samples were collected between 20+0 ...
Matthews Silva Martins, Julyane N. S. Kaihara, Diego Fortes Salgueiro, Viviane Cunha Cardoso, Silvana Maria Quintana, Ricardo Carvalho Cavalli, Valerio Garrone Barauna, Valeria Cristina Sandrim   +7 more
wiley   +1 more source

Sequence-Encoded Frustration Directs the Formation of Abridged G-Quadruplex Architectures. [PDF]

Angew Chem Int Ed Engl
Programmable frustration reshapes the free‐energy surface (FES) of guanine‐quadruplex (G4) folding, stabilizing an abridged G4 and a G‐triplex intermediate. ABSTRACT Frustration—competing interactions that cannot be simultaneously optimized—shapes energy landscapes in proteins and soft matter, but has rarely been exploited as a programmable design ...
Qian Y, Ali MY, Karsisiotis AI, Dillon P, Dvorkin SA, McPherson PAC, Webba da Silva M.   +6 more
europepmc   +3 more sources

Decay Pathways of Thymine Revisited

, 2018
The decay of electronically excited states of thymine (Thy) and thymidine 5′-monophosphate (TMP) was studied by time-resolved UV/vis and IR spectroscopy.
Wolfgang J. Schreier (1317468), Bert M. Pilles (1317477), Benjamin Maerz, Jinquan Chen, Wolfgang Zinth, Benjamin Maerz (3114789), Benjamin P. Fingerhut (1287117), Bern Kohler, Bern Kohler (1359810), Bert M. Pilles, Benjamin P. Fingerhut, Dominik B. Bucher, Peter Gilch (1317462), Wolfgang J. Schreier, Jinquan Chen (837183), Dominik B. Bucher (5244533), Wolfgang Zinth (1317471), Peter Gilch   +17 more
core   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Thymines opposite to bulky aristolactam-DNA adducts in duplex DNA are not targeted by human thymine-DNA glycosylase [PDF]

PeerJ
Background Consumption of aristolochic acids (AA) from the plant Aristolochia results in the formation of bulky aristolactam-dA (dA-AL) and aristolactam-dG (dG-AL) adducts in cellular DNA ultimately leading to the development of urothelial cancer ...
Diana Manapkyzy, Gulzhan Zhamanbayeva, Viktoriya Sidorenko, Radha Bonala, Francis Johnson, Bakhyt T. Matkarimov, Dmitry Zharkov, Murat K. Saparbaev, Sabira Taipakova   +8 more
doaj   +2 more sources

Beyond Tradition: An Integrated Toxicological, Ecological, and Public Health Perspective on Aristolochic Acids

Journal of Applied Toxicology, EarlyView.
ABSTRACT Aristolochia species have long been used in traditional medicine for their presumed anti‐inflammatory, analgesic and antimicrobial properties. However, extensive toxicological and epidemiological evidence now demonstrates that these plants contain aristolochic acids (AAs) I and II, highly potent nephrotoxic, genotoxic, and carcinogenic ...
Victor Ventura de Souza, Lara Rodrigues De Andrade, Tatiana da Silva Souza   +2 more
wiley   +1 more source

Lack of Association Between Toll-like Receptor 2 Polymorphisms (R753Q and A-16934T) and Atopic Dermatitis in Children from Thrace Region of Turkey

Balkan Medical Journal, 2017
Background: Atopic dermatitis is the most common chronic inflammatory skin disease. A complex interaction of both genetic and environmental factors is thought to contribute to the disease. Aims: To evaluate whether single nucleotide polymorphisms in the
Ceren Can, Mehtap Yazıcıoğlu, Hakan Gürkan, Hilmi Tozkır, Adnan Görgülü, Necdet Hilmi Süt   +5 more
doaj   +1 more source