Results 171 to 180 of about 74,896 (329)

Universal Regulation of DNA Polymerase via Photocaged Primer Enables Light‐Start Isothermal Amplification on Demand

Advanced Science, Volume 13, Issue 3, 14 January 2026.
A simple and general photoactivatable approach is developed to regulate DNA polymerase activity, enabling light‐start isothermal amplification on demand. The molecular dynamics simulations reveals that the photocaged primer blocks DNA polymerase activity by inhibiting the conformational change of the polymerase.
Min Qing, Yufan Qin, Zhijin Li, Xiufang Yu, Jianbo Wang, Xiaoqiong Liu, Xin Chen, Chao Yu   +7 more
wiley   +1 more source

The dgt gene of Escherichia coli facilitates thymine utilization in thymine‐requiring strains

, 2011
Mark Itsko, Roel M. Schaaper
openalex   +2 more sources

Aptamer Engineering: Strategies for Discovering Functional Nucleic Acids for Next‐Generation Diagnostics and Biosensing

Advanced Science, Volume 13, Issue 2, 9 January 2026.
The advent of aptamers has highlighted their potential as alternatives to antibodies, overcoming limitations of structural instability and production cost. However, conventional approaches such as SELEX remain slow and labor‐intensive. This review examines recent advances in aptamer engineering, emphasizing in vitro and AI‐driven in silico strategies ...
John V. L. Nguyen, Ahlem Meziadi, Cyrill Brunner, Maureen McKeague, Lidija Malic, Maryam Tabrizian   +5 more
wiley   +1 more source

What is in a name? Rethinking SMUG1 in genome maintenance. [PDF]

NAR Cancer
Rudolfova N, Skjetne AM, Montaldo NP, Visnes T, Nilsen HL, Michel M.   +5 more
europepmc   +1 more source

INABILITY OF THYMINE TO REPLACE URACIL FOR GROWTH OF THERMOBACTERIUM ACIDOPHILUM ( LACTOBACILLUS ACIDOPHILUS ) [PDF]

, 1962
Chitra Biswas, Harry P. Broquist
openalex   +1 more source

Alu Overexpression Leads to an Increased Double‐Stranded RNA Signature in Dermatomyositis

Arthritis &Rheumatology, Volume 78, Issue 1, Page 209-222, January 2026.
Objective Dermatomyositis is an autoimmune condition characterized by a high interferon signature of unknown etiology. Because coding sequences constitute <1.2% of our genomes, there is a need to explore the role of the noncoding genome in disease pathogenesis.
Rayan Najjar, Andrew Mammen, Tomas Mustelin   +2 more
wiley   +1 more source

Quantitative and spatially defined functionalization of nanostructures by overcoming the strong steric hindrance through bioinspired nucleobase interactions. [PDF]

Chem Sci
Chen H, Xue Y, Yao N, Cheng R, Liu J, Bao J, Hua Z.   +6 more
europepmc   +1 more source

Flow Cytometry: Advances, Challenges and Trends

BioEssays, Volume 48, Issue 1, January 2026.
Recent advances in flow cytometry span hardware, data processing, and AI‐driven analytics. Emerging modalitiesincluding spectral, imaging, mass, and nano/EV cytometryenable higher‐parameter and small‐particle detection. Integrated machine learning drives a shift from manual gating toward automated multi‐omics workflows.
J. Paul Robinson, Grzegorz B. Gmyrek, Bartek Rajwa   +2 more
wiley   +1 more source

Nucleobase self-assembly: aggregation, morphological characterization, and toxicity analysis. [PDF]

Nanoscale Adv
Dave R, Jaiswal A, Singh A, Naseer A, Patel M, Nazir A, Bhatia D, Gour N, Verma S.   +8 more
europepmc   +1 more source

The Double Face of Base Excision Repair: Preventing and Triggering Double‐Strand Breaks

BioEssays, Volume 48, Issue 1, January 2026.
Base excision repair is conserved from bacteria to man, robustly eliminating oxidized bases in DNA and reinserting the appropriate nucleotide to restore an intact double helix. Recent results describe conditions and mechanisms that misregulate long‐patch BER to generate double‐strand breaks, triggering chromosome fragmentation and cell death, altering ...
Susan M. Gasser
wiley   +1 more source