Results 1 to 10 of about 46,331 (223)

Understanding the Impact of Individual Nucleotide on Oxford Nanopore Current Signals With Interpretable Prediction Models [PDF]

Bioinformatics and Biology Insights
Oxford nanopore sequencing enabled real-time, long-read analysis of DNA by detecting ionic current signals associated with K-mer sequences. Although many studies analyzed sequence and modification detection, our understanding of how multiple nucleotides ...
Yenan Wang, Zhixing Wu, Jia Meng
doaj   +2 more sources

Thymine Sensitizes Gram-Negative Pathogens to Antibiotic Killing

Frontiers in Microbiology, 2021
Diminished antibiotic susceptibility of bacterial pathogens is an increasingly serious threat to human and animal health. Alternative strategies are required to combat antibiotic refractory bacteria.
Yuan Liu, Yuan Liu, Yuan Liu, Yuan Liu, Kangni Yang, Yuqian Jia, Jingru Shi, Ziwen Tong, Zhiqiang Wang, Zhiqiang Wang, Zhiqiang Wang   +10 more
doaj   +1 more source

Identification of discriminant features from stationary pattern of nucleotide bases and their application to essential gene classification

Frontiers in Genetics, 2023
Introduction: Essential genes are essential for the survival of various species. These genes are a family linked to critical cellular activities for species survival.
Ranjeet Kumar Rout, Saiyed Umer, Monika Khandelwal, Smitarani Pati, Saurav Mallik, Saurav Mallik, Bunil Kumar Balabantaray, Hong Qin   +7 more
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On the prebiotic selection of nucleotide anomers: A computational study

Heliyon, 2022
Present-day known predominance of the β- over the α-anomers in nucleosides and nucleotides emerges from a thermodynamic analysis of their assembly from their components, i.e. bases, sugars, and a phosphate group.
Lázaro A.M. Castanedo, Chérif F. Matta
doaj   +1 more source

AT Homopolymer Strings in Salmonella enterica Subspecies I Contribute to Speciation and Serovar Diversity

Microorganisms, 2021
Adenine and thymine homopolymer strings of at least 8 nucleotides (AT 8+mers) were characterized in Salmonella enterica subspecies I. The motif differed between other taxonomic classes but not between Salmonella enterica serovars.
Jean Guard, Adam R. Rivers, Justin N. Vaughn, Michael J. Rothrock, Jr., Adelumola Oladeinde, Devendra H. Shah   +5 more
doaj   +1 more source

Mechanism of nucleotide incorporation opposite a thymine-thymine dimer by yeast DNA polymerase η [PDF]

Proceedings of the National Academy of Sciences, 2003
DNA polymerase η (Polη) has the unique ability to replicate through UV-light-induced cyclobutane pyrimidine dimers. Here we use pre-steady-state kinetic analyses to examine the mechanism of nucleotide incorporation opposite a cis - syn thymine-thymine (TT) dimer and an identical nondamaged ...
M Todd, Washington, Louise, Prakash, Satya, Prakash   +2 more
openaire   +2 more sources

Alternative metabolic fates of thymine nucleotides in human cells [PDF]

Biochemical Journal, 1981
Three types of experiments have been used to study the metabolism of thymine nucleotides by human cells. (1) Cells were labelled continuously with [3H]thymidine and the incorporation of label into DNA compared with the specific radioactivities of pools of individual thymine nucleotides separated by chromatography on polyethylene-imine-cellulose.
M R, Taheri, R G, Wickremasinghe, A V, Hoffbrand   +2 more
openaire   +2 more sources

Phylogenetic analysis of Anguilla marmorata population in Thua Thien Hue, Vietnam based on the cytochrome C oxidase I (COI) gene fragments

AMB Express, 2020
The giant mottled eel is a species with high commercial value so overfishing, river management, and water pollution have negatively affected its movement and population numbers. Anguilla marmorata (eel) was listed in the Vietnam Red Data Book 2007 with a
Kieu Thi Huyen, Nguyen Quang Linh
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Nucleotide discrimination with DNA immobilized in the MspA nanopore. [PDF]

PLoS ONE, 2011
Nanopore sequencing has the potential to become a fast and low-cost DNA sequencing platform. An ionic current passing through a small pore would directly map the sequence of single stranded DNA (ssDNA) driven through the constriction.
Elizabeth A Manrao, Ian M Derrington, Mikhail Pavlenok, Michael Niederweis, Jens H Gundlach   +4 more
doaj   +1 more source

Hydrophilic interaction liquid chromatography coupled to quadrupole-time-of-flight mass spectrometry for determination of nuclear and cytoplasmatic contents of nucleotides, nucleosides and their nucleobases in food yeasts

Talanta Open, 2021
Hydrophilic interaction liquid chromatography using a zwitterionic phase, coupled with high-resolution mass spectrometry based on quadrupole and time-of-flight mass analyser (HILIC-Q-TOF-MS) is applied for the determination of four nucleobases (adenine ...
Marta Pastor-Belda, Inmaculada Fernández-Caballero, Natalia Campillo, Natalia Arroyo-Manzanares, Manuel Hernández-Córdoba, Pilar Viñas   +5 more
doaj   +1 more source