Results 121 to 130 of about 46,331 (223)
Organic Hazes as a Source of Life’s Building Blocks to Warm Little Ponds on the Hadean Earth
The Planetary Science JournalOver 4 billion years ago, Earth is thought to have been a hazy world akin to Saturn’s moon Titan. The organic hazes in the atmosphere at this time could have contained a vast inventory of life’s building blocks and thus may have seeded warm little ponds ...
Ben K. D. Pearce +3 more
doaj +1 more source
Insights Into Gut Barrier Dysfunction and Metabolic Alterations in Mycophenolate‐Induced Enteropathy
Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 3, March 2026.ABSTRACT Mycophenolic acid (MPA) is a widely used immunosuppressant whose use is often limited by gastrointestinal toxicity. Gut bacterial hydrolysis of liver‐derived MPA glucuronides increases local exposure to MPA, potentially impairing epithelial barrier function and cellular metabolism.
Clarisse Brossier +6 more
wiley +1 more source
The Plant GenomeInsights into changes in genome base composition underlying crop domestication can be gained by using comparative genomics. With this approach, previous studies have reported that crop genomes during domestication accumulate more nucleotides adenine (A ...
Xiangjian Gou +6 more
doaj +1 more source
Журнал микробиологии, эпидемиологии и иммунобиологииIntroduction. The expression of the ctxAB and tcpA-F genes encoding the main pathogenicity factors of the Vibrio cholerae is controlled by regulatory genes.
Nikita A. Plekhanov +4 more
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Advanced Science, Volume 13, Issue 8, 9 February 2026.Folic acid (FA) and multivitamins/minerals (MVM) are recommended for the prevention of neural tube defects (NTDs). Using a novel human neural tube‐like organoid system and mouse models, the study compares the effectiveness of two supplements on NTDs and cellular behaviors.
Huili Li +3 more
wiley +1 more source
BMC GenomicsEnsuring sufficient gRNA transcript levels is critical for obtaining optimal CRISPR-Cas9 gene editing efficiency. The standard gRNA scaffold contains a sequence of four thymine nucleotides (4T), which is known to inhibit transcription from Pol III ...
Yu C. J. Chey +12 more
doaj +1 more source
Animal Research and One Health, Volume 4, Issue 1, Page 14-27, February 2026.The paper is divided into three main sections: a review of the development of spatial transcriptomics technology, its applications in livestock and poultry research, and its future prospects. This article provides an overview of the current state of spatial transcriptomics in animal research, exploring its integration with multiomics technologies as ...
Mingyu Wang +5 more
wiley +1 more source
Clinical Pharmacology in Drug Development, Volume 15, Issue 2, February 2026.Abstract This Phase 1 study investigated the pharmacokinetics and safety of a single dose of the FDA‐approved doxecitine and doxribtimine (266.6 mg/kg; 133.3 mg/kg of deoxycytidine [dC] and deoxythymidine [dT]) in participants with severe (n = 8) or moderate (n = 8) renal impairment (estimated glomerular filtration rate [eGFR] 15–29 mL/min/1.73 m2 and ...
Aravind Mittur, Susan A. VanMeter
wiley +1 more source
CcpA-mediated regulation of cellular energy metabolism in the ruminal bacterium Streptococcus bovis
Microbiology SpectrumThis study investigated the cellular energy metabolite profiles of Streptococcus bovis S1. Glucose concentrations of 5 or 50 mM and the presence or absence of ccpA were applied during the cultivation of S. bovis S1. Results revealed the identification of
Yunan Weng +4 more
doaj +1 more source
Base Editing‐Mediated Targeted Evolution of Populus CesA8 Boosts Cellulose Production
Plant Biotechnology Journal, EarlyView.
Xinrui Jia +4 more
wiley +1 more source