Results 191 to 200 of about 41,566 (244)

Evidence that the protein phosphatase activity of PTEN contributes to embryonic development and tumour suppression in mice

Tibarewal P, Spinelli L, Kriplani N, Wise H, Poncet N, Marzano G, Anderson KE, Grzes KM, Varyova Z, Adil M, Downes CP, Hawkins PT, Stephens LR, Storey KG, Cantrell DA, Vanhaesebroeck B, Leslie NR.   +16 more
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Thymocyte Apoptosis

Journal of Clinical Immunology, 1999
Apoptosis is the fate of most thymocytes. Many molecules participate in the decision of whether a thymocyte is to live or to die, including cell surface receptors, such as the T cell receptor for antigen, Notch-1, and costimulatory receptors, ligand-regulated nuclear transcription factors such as the glucocorticoid receptor, signaling, and effector ...
Y, Yang, J D, Ashwell
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Thymocytes Positively Select Thymocytes in Human System

Human Immunology, 1997
We previously demonstrated the expression of MHC class II molecules in a significant percentage of human fetal and postnatal thymocytes. These results, at that time, raised the question as to whether the MHC class II molecules on immature thymocytes could actively be involved in the selection of immature T cells.
E Y, Choi, W S, Park, K C, Jung, D H, Chung, Y M, Bae, T J, Kim, H G, Song, S H, Kim, D I, Ham, J H, Hahn, J, Kim, K, Kim, T S, Hwang, S H, Park   +13 more
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Positive Selection of Thymocytes

Annual Review of Immunology, 1995
Differentiation of αβ T cell receptor (TCR)-expressing T cells involves an obligatory interaction with self-major histocompatibility complex (MHC) molecules in the thymus. This process, called positive selection, both rescues thymocytes from programmed cell death and induces their differentiation into mature T cells.
P J, Fink, M J, Bevan
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Antibodies in Thymocytes

Nature, 1963
FRAGRAEUS was not able to show plasmocytes in normal thymus1 ; nor did she find plasmocytes in thymus after antigen injections2. After removal of the thymus in adult rats the antibody production is unchanged3. In spite of these results which ascribe no important influence on antibody production by the thymus there are still several clinical signs which
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Specific Antigenicity of Thymocytes

Nature, 1967
THYMOCYTES (thymic lymphocytes) are believed to differ from lymphoid cells of other organs. They show a different response to a variety of physical, chemical and biological stimuli1, such as irradiation2 and phytohaemagglutinin3, and it has been claimed that they have an epithelial rather than mesenchymal origin4.
Potworowski, E F, Nairn, R C
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LDH analysis of human thymocytes and thymocyte subsets.

The Journal of Immunology, 1984
Abstract The lactate dehydrogenase (LDH) isoenzyme pattern (expressed as the B:A subunit ratio) and two enzymes of the purine metabolism adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) (expressed as the ADA/PNP ratio) were studied in human prenatal thymocytes, in subsets of human infant thymocytes, and in peripheral T
J R, Plum, M, De Smedt, L J, Sabbe, J E, De Roose   +3 more
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Thymocyte transformation enhanced

Nature Medicine, 2014
A new study identifies recurrent somatic duplications of a NOTCH1-driven enhancer of MYC in human T cell leukemia. This enhancer is required for both normal and malignant T cell development.
Gayle P, Pouliot, Alejandro, Gutierrez
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The regulation of apoptosis in thymocytes

Biochemical Society Transactions, 1994
606 The regulation of apoptosis in thymocytes David J. McConkey*$, Mikael Jondalt and Sten Orreniust *Department of Cell Biology, Box 173, The University of Texas, MD Anderson Cancer Center, I 5 I 5 Holcombe Blvd., Houston, TX 77030, U.S.A., +Departments of Microbiology and Tumor Biology, Karolinska Institute, Box 60400, SI040 I Stockholm, Sweden, and $
D J, McConkey, M, Jondal, S, Orrenius
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A model of thymocyte proliferation

Journal of Theoretical Biology, 1975
Abstract A steady-state model, based upon an analytical approach to the interpretation pf thymic radioautographic data is presented. In the model the process of cellular proliferation is represented by a feedback amplifier. It is shown by computer simulation that a model based on this conception, in which cellular flow through G 1 compartments is ...
J W, Prothero, R W, Tyler
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