Results 61 to 70 of about 5,476 (161)

Serum exocrine pancreas enzymes are biomarkers of immunotherapy response in new-onset type 1 diabetes

Frontiers in Endocrinology
IntroductionThe immune-mediated destruction of insulin-producing β-cells characterizes type 1 diabetes. Nevertheless, exocrine pancreatic enzymes, including amylase, lipase, and trypsin, are also significantly reduced in type 1 diabetes.
Brittany Sorensen Bruggeman, Savanna Gornisiewicz, Rhonda Bacher, Kieran McGrail, Martha Campbell-Thompson, Clive Wasserfall, Laura M. Jacobsen, Laura M. Jacobsen, Mark Atkinson, Michael J. Haller, Desmond A. Schatz   +10 more
doaj   +1 more source

Salvage With Revumenib: Targeting KMT2A‐Rearranged Isolated Leukemia Cutis Identified in the Extramedullary Disease

eJHaem, Volume 7, Issue 4, August 2026.
ABSTRACT Acute myeloid leukemia (AML) is an aggressive hematologic malignancy associated with a high risk of relapse. Leukemia cutis is characterized by the presence of neoplastic leukocytes infiltrating the skin. Here, we present a previously treated AML patient who relapsed with isolated leukemia cutis without bone marrow involvement. Fluorescence in
Bana Antonios, Xuemei Wu, Lynn Johnson, Avani Ahuja, Megan Blauvelt, Margaret Aronckes, Nina Dutton, Jennifer Dujmic, Salman Fazal, Taimoor I. Sheikh   +9 more
wiley   +1 more source

Evaluation of Global Immune Biomarkers to Predict Infections in Lung Transplant Recipients

Clinical Transplantation, Volume 40, Issue 8, August 2026.
ABSTRACT Background Immune biomarkers could assess levels of immunosuppression and predict infections in transplant recipients. We aimed to evaluate the absolute lymphocyte count (ALC), absolute neutrophil count (ANC), Quantiferon‐Monitor and the mitogen component of the Quantiferon‐CMV assay alone and combined to predict serious opportunistic ...
Quoc Nguyen, Michael J. Lydeamore, Adina Dessauer, Gregory I. Snell, Glen P. Westall, Anton Y. Peleg, Bradley J. Gardiner   +6 more
wiley   +1 more source

Early outcomes in human lung transplantation with Thymoglobulin or Campath-1H for recipient pretreatment followed by posttransplant tacrolimus near-monotherapy [PDF]

, 2005
Objectives: Acute and chronic rejection remain unresolved problems after lung transplantation, despite heavy multidrug immunosuppression. In turn, the strong immunosuppression has been responsible for mortality and pervasive morbidity.
Iacono, Aldo, Johnson, Bruce, Iacono, A, McCurry, KR, Zeevi, A, Yousem, S, Husain, Shahid, Starzl, TE, Girnita, A, Husain, S, Starzl, Thomas E., McCurry, Kenneth R., Zeevi, Adrianna, Yousem, Samuel, Iacano, A, Hattler, Brack G., Zaldonis, Diana, McCurry, K, Girnita, Alin, Zaldonis, D, Johnson, B, Hattler, BG   +21 more
core   +1 more source

Induction Therapies Determine the Distribution of Perforin and Granzyme B Transcripts in Kidney Transplant Recipients

Biomedicines
Peripheral blood mononuclear cells contain secretory granules with Perforin and Granzyme B for defense against pathogens. The objective of the present study was to compare the effects of immunosuppressive induction therapies on Perforin and Granzyme B ...
Dino Pipic, Marianne Rasmussen, Qais W. Saleh, Martin Tepel   +3 more
doaj   +1 more source

A Phase 2 Trial of Frexalimab, a CD40L Antagonist, in Adolescents and Adults With Recent‐Onset Type 1 Diabetes (FABULINUS): Rationale and Study Design

Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 6584-6594, August 2026.
ABSTRACT Introduction Type 1 diabetes (T1D) is a chronic autoimmune disease, characterised by progressive destruction of the insulin‐producing pancreatic β‐cells. Preserving remaining β‐cells at the time of diagnosis may improve long‐term outcomes. Frexalimab is a humanised monoclonal antibody specific for CD40L undergoing evaluation for treatment of ...
Andriy Cherkas, Baerbel Rotthaeuser, Niels Porksen, Pascale Labard, My‐Liên Nguyên‐Pascal, Mathieu Coudert, Baptiste Berthou, Marie Baccara‐Dinet, Gabor Boka, Mark Peakman, Felix Reschke, Michael J. Haller   +11 more
wiley   +1 more source

Human CD4+CD25+ Cells in Combination with CD34+ Cells and Thymoglobulin to Prevent Anti-hematopoietic Stem Cell T Cell Alloreactivity [PDF]

, 2011
Cotransplantation of human CD34+ hematopoietic stem cells (HSC) and CD4+CD25+FoxP3+ regulatory T cells (Tregs) could prevent anti-HSC alloreactivity and reduce the risk of rejection in HLA mismatched transplants.
Mahmud, Nadim, Nicolini, Benedetta, Dolores Mahmud, Benedetta Nicolini, Rondelli, Damiano, Mario Arpinati, Arpinati, Mario, Mahmud, Dolores, Lennert van den Dries, Damiano Rondelli, Nadim Mahmud, van den Dries, Lennert   +11 more
core   +1 more source

Surveillance of CMV Terminase Gene Mutations in Allogeneic Hematopoietic Stem Cell Transplant Recipients Receiving Letermovir Prophylaxis

Journal of Medical Virology, Volume 98, Issue 7, July 2026.
ABSTRACT Letermovir (LMV), a CMV‐specific terminase inhibitor, is recommended for cytomegalovirus (CMV) prophylaxis in CMV‐seropositive allogeneic hematopoietic stem cell transplant (alloHSCT) recipients. The association between low‐level CMV DNAemia during prophylaxis and the emergence of mutations in CMV terminase complex genes remains unclear.
Amandine Caillault, Alienor Xhaard, Severine Mercier‐Delarue, Linda Feghoul, Julien Robert, Nathalie Schnepf, David Michonneau, Marie Robin, Flore Sicre de Fontbrune, Eleonore Kaphan, Mathilde Ruggiu‐Goiran, Pedro Henrique de Lima Prata, Florian Chevillon, Matthieu Jestin, Nathalie Dhedin, Gerard Socie, Régis Peffault de Latour, Maud Salmona, Jérôme LeGoff   +18 more
wiley   +1 more source

First two bilateral hand transplantations in India (Part 4): Immediate post-operative care, immunosuppression protocol and monitoring

Indian Journal of Plastic Surgery, 2017
Introduction: Being able to counter immune-mediated rejection has for decades been the single largest obstacle for the progress of vascular composite allotransplantation (VCA).
Subramania Iyer, Mohit Sharma, P. Kishore, Jimmy Mathew, R. Janarthanan, Raghuveer Reddy, Abhijeet Wakure, Sundeep Vijayaraghavan, S. M. Chetan Mali, Visakh Varma, Ashish Chaudhari, Swapnil Dhake, Akshay Omkumar, George Kurian, Rajesh Nair, Anil Mathew, Zachariah Paul, Malini Eapen, Lalitha Biswas   +18 more
doaj   +1 more source

Pretransplant Malnutrition Risk Components are Associated With Adverse Outcomes After Simultaneous Pancreas and Kidney and Solitary Pancreas Transplantation

Clinical Transplantation, Volume 40, Issue 7, July 2026.
ABSTRACT Background Malnutrition is common among patients with end‐organ disease. The impact of any criterion of malnutrition (weight loss, muscle depletion, fat depletion, inadequate oral intake, or reduced functionality) pretransplant among simultaneous pancreas‐kidney (SPK) or solitary pancreas transplant (SPT) recipients is understudied. Methods In
Katrina Kennedy, Jessa Engelken, Megan Rolfson, Angela Zhou, Mina L. Gibes, Najiyah Salwa, Didier Mandelbrot, Dixon Kaufman, Jon Odorico, Sandesh Parajuli   +9 more
wiley   +1 more source