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Thymoquinone: a promising antidiabetic agent
International Journal of Diabetes in Developing Countries, 2012The antidiabetic property of Nigella sativa seeds oil are attributable to the presence of Thymoquinone (TQ) which is considered as a major phytochemical component of the seeds volatile oil. The aim of this review is to highlight the potential of thymoquinone as an antidiabetic agent and the latest reported research investigations regarding the ...
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Immunomodulatory effect of thymoquinone on atopic dermatitis
Molecular Immunology, 2018Atopic dermatitis (AD) or atopic eczema is a skin disease characterized with itching, increased serum level of immunoglobulin E, and peripheral eosinophilia. Thymoquinone (TQ) is an important ingredient of Nigella sativa seeds having antioxidant and anti-inflammatory effects.Present study investigates the immunomodulatory effects of Thymoquinone (TQ ...
Hina Aslam +3 more
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Anticancer Action of Thymoquinone
2018Thymoquinone (TQ) is a biologically active compound found in the Nigella sativa and extensively studied over the decades for its implications in diseases management without promoting the adverse side effects. An extensive number of researches have been performed to evaluate the efficacy of TQ in killing of cancer cells through modulating several ...
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Antidiabetic Action of Thymoquinone
2018Diabetes has become the most common metabolic disease worldwide. Hyperglycemia has a key role in the diseases associated with diabetic complications. N. sativa seeds possess antidiabetic and hypoglycemic activity. It is the thymoquinone (TQ) content of these seeds that is the main constituent associated with the antidiabetic activity of the plant.
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Nonenzymatic reduction of thymoquinone in physiological conditions
Free Radical Research, 2007Thymoquinone (TQ) is the bioactive constituent of the volatile oil of Nigella sativa L. and has been shown to exert antioxidant antineoplastic and anti-inflammatory effects. During the study of its possible mechanism of action, we found that TQ reacts chemically (i.e. nonenzymatically) with glutathione (GSH), NADH and NADPH.
K H, Khalife, G, Lupidi
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Thymoquinone-protoflavone hybrids
4th International Symposium of Young Researchers on Medicinal Plants and Natural Product Research, 2023István Zupkó +8 more
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Biochimica et Biophysica Acta (BBA) - General Subjects, 2015
Thymoquinone (TQ) has been documented to possess chemo-preventive and chemotherapeutic antitumor effects. Studies reported that TQ inhibits the growth of cancer cells in animal models, culture and xenografted tumors. Molecular mechanisms underlying these anticancer effects were attributed to inductions of cell cycle arrest, apoptosis, oxidative damage ...
Alaa A, Salem +3 more
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Thymoquinone (TQ) has been documented to possess chemo-preventive and chemotherapeutic antitumor effects. Studies reported that TQ inhibits the growth of cancer cells in animal models, culture and xenografted tumors. Molecular mechanisms underlying these anticancer effects were attributed to inductions of cell cycle arrest, apoptosis, oxidative damage ...
Alaa A, Salem +3 more
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Antimicrobial Action of Thymoquinone
2018In recent years, pathogens have adopted various mechanisms to combat the onslaught of currently available antibiotics. This led to the emergence of the phenomenon of antibiotic resistance in microorganisms. Antibiotic resistance has rendered many previously effective antibiotics into useless chemicals that are resulting in the dearth of available ...
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