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Structural and vibrational analysis of thymoquinone
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2010The molecular structure of 2-isopropyl-5-methyl-1,4-benzoquinone, C(6)O(2)H(2) (CH(3))(3)CH, has been optimized using methods based on density functional theory (DFT) and Moller-Plesset second-order perturbation theory (MP2). As regards C(6)O(2)H(2) (CH(3))(3)CH, two populated conformations with C(1) (trans) and C(s) (cis) symmetries are obtained, the ...
A B, Raschi +4 more
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Therapeutic implications and clinical manifestations of thymoquinone
Phytochemistry, 2022Thymoquinone (TQ), a natural phytochemical predominantly found in Nigella sativa, has been investigated for its numerous health benefits. TQ showed anti-cancer, anti-oxidant, and anti-inflammatory properties, validated in various disease models. The anti-cancer potential of TQ is goverened by anti-proliferation, cell cycle arrest, apoptosis induction ...
Manzar, Alam +5 more
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The Diepoxides of Thymoquinone
Australian Journal of Chemistry, 1989Structures for the cis and trans diepoxides of thymoquinone are assigned from n.m.r. and X-ray crystallographic studies.
Carman M.R. +4 more
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In vitro toxicological properties of thymoquinone
Food and Chemical Toxicology, 2009Nigella sativa has been traditionally used for the treatment of inflammations, liver disorders, and arthritis. Experimentally, it has been demonstrated that N. sativa extracts and the main constituent of their volatile oil, thymoquinone, possess antioxidant, anti-inflammatory and hepato-protective properties.
M, Khader, N, Bresgen, P M, Eckl
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Thymoquinone Anticancer Discovery: Possible Mechanisms
Current Drug Discovery Technologies, 2015Medicinal plants are known for their many advantages, including the ability to treat diseases such as cancer. Nigella sativa and its active constituent thymoquinone (TQ) have long been used in traditional medicine for treating various conditions related to the respiratory and gastrointestinal systems as well as breast, colorectal, gastric, hepatic ...
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Immunomodulatory and Anti-inflammatory Effects of Thymoquinone
Cardiovascular & Hematological Disorders-Drug Targets, 2018The immunomodulatory properties of Nigella sativa seed, as a basis of its clinical applications by many cultures have been reviewed. Thymoquinone (TQ) is one of the major bioactive components of the volatile oil of N. sativa seeds.The review on immunomodulatory and anti- inflammatory effects of TQ was focused on published literature in the English ...
Hanieh, Shaterzadeh-Yazdi +4 more
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Thymoquinone: Chemistry and Functionality
2020Thymoquinone (TQ) is found in nature as one of the constituents of the volatile oil fraction of black seeds (Nigella sativa L.). Nowadays, more research interest is directed toward TQ due to its versatile biological activities especially its anticancer potentials.
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An Overview of Hepatoprotective Effects of Thymoquinone
Recent Patents on Food, Nutrition & Agriculture, 2018Liver diseases are globally recognized as major medical problems. Several species of herbal medicine have been investigated for the management of liver-related diseases.In this context, Thymoquinone (TQ) as the main constituent of Nigella sativa has long been focused for the treatment of liver diseases in recent years. To suppressing liver diseases, it
Mohammad-Foad, Noorbakhsh +4 more
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Thymoquinone attenuates lead‐induced nephropathy in rats
Journal of Biochemical and Molecular Toxicology, 2018AbstractKidney hazards from lead (Pb) exposure are one of the fastest growing areas of concern in toxicology today. The thymoquinone (TQ) renoprotective effect against Pb‐induced nephropathy has not previously been studied. Therefore, adult male Wistar rats were treated with Pb (2000 ppm of Pb acetate in drinking water) and/or TQ (5 mg/kg/day, per os).
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Hepatoprotective Action of Thymoquinone
2018Nigella sativa (black cumin) seeds and its principal bioactive component, thymoquinone (TQ), have been used for centuries in folk medicine because of their exceptional healing power to a wide range of diseases. Nigella sativa plant has been regarded as nature’s miracle herb.
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