Results 51 to 60 of about 163,535 (332)

Variability in the local and global composition of human T-cell receptor repertoires during thymic development across cell types and individuals [PDF]

arXiv, 2023
The adaptive immune response relies on T cells that combine phenotypic specialization with diversity of T cell receptors (TCRs) to recognize a wide range of pathogens. TCRs are acquired and selected during T cell maturation in the thymus. Characterizing TCR repertoires across individuals and T cell maturation stages is important for better ...
arxiv  

“Therapies Through Gut:” Targeted Drug Delivery for Non‐Gastrointestinal Diseases by Oral Administration

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray, Shehzahdi S. Moonshi, Hang Thu Ta   +2 more
wiley   +1 more source

Evaluation of the acute toxicity and 28‐days subacute toxicity of the alcoholic extract from Ganoderma leucocontextum

Food Science &Nutrition, Volume 11, Issue 1, Page 434-442, January 2023., 2023
The toxicity of Ganoderma leucocontextum was evaluated for the first time. No toxicological changes were found in acute and subacute toxicity test. Ganoderma leucocontextum showed a good safety profile in animal study. Abstract Ganoderma leucocontextum is a well‐known traditional medicine in Tibet Autonomous Region, which has benefits, such as anti ...
Shizhan Deng, Er‐bu AGA, Hongjun Xie, Hai Xiong, Bengui Ye   +4 more
wiley   +1 more source

Quantification of dendritic cell subsets in human thymus tissues of various ages

Immunity & Ageing, 2021
Background Dendritic cells (DCs) in the thymus are involved in central tolerance formation, but they also have other functions in the thymus, such as pathogen recognition. The density changes of human thymic DCs have been hardly investigated.
Yan Li, Pei Chen, Hao Huang, Huiyu Feng, Hao Ran, Weibin Liu   +5 more
doaj   +1 more source

Inorganic Nanomaterials Meet the Immune System: An Intricate Balance

Advanced Healthcare Materials, EarlyView.
Metal nanomaterials influence the immune responses, such as cytokine production and T‐cell activity. Unintended immune modulation can have significant consequences while its fine‐tuning may transform the oncology care. Within this review, a critical analysis is offered regarding the nano/immune‐interaction and suggests the future research directions to
Gloria Pizzoli, Marco Gargaro, Giuliana Drava, Valerio Voliani   +3 more
wiley   +1 more source

Antioxidant and antimicrobial potential of water lily extracts and their effects on the quality of frozen Nile tilapia (Oreochromis niloticus) fillets

Food Science &Nutrition, Volume 11, Issue 1, Page 535-544, January 2023., 2023
Extension of shelf life using natural antioxidant like water lily extracts is desirable for highly perishable seafood preservation than the synthetic one. In this study, water lily ethanolic extract has considerable amount of antioxidant and antimicrobial potentiality, which effectively reduced the quality deterioration, inhibited the lipid oxidation ...
Md. Apon Dulal, Israt Jahan, Md. Golam Rasul, Md. Rabiul Islam, Murshida Khan, A. K. M. Azad Shah   +5 more
wiley   +1 more source

Pictorial essay. Pathology of the thymus on CT-imaging.

Journal of the Belgian Society of Radiology, 2012
A number of masses arise in relation to the thymus. The radiologist has an important role regarding the differential diagnosis between non-tumoral thymic pathology and malignant thymic tumors.
R Peters, O Peters, S Braak, J Verschakelen   +3 more
doaj   +1 more source

Postnatal Involution and Counter-Involution of the Thymus

Frontiers in Immunology, 2020
Thymus involution occurs in all vertebrates. It is thought to impact on immune responses in the aged, and in other clinical circumstances such as bone marrow transplantation. Determinants of thymus growth and size are beginning to be identified.
Jennifer E. Cowan, Yousuke Takahama, Avinash Bhandoola, Izumi Ohigashi   +3 more
doaj   +1 more source

IL-2 and IL-15 drive intrathymic development of distinct periphery-seeding CD4+Foxp3+ regulatory T lymphocytes

Frontiers in Immunology, 2022
Development of Foxp3-expressing regulatory T-lymphocytes (Treg) in the thymus is controlled by signals delivered in T-cell precursors via the TCR, co-stimulatory receptors, and cytokine receptors.
Cécile Apert, Ariel O. Galindo-Albarrán, Ariel O. Galindo-Albarrán, Sarah Castan, Claire Detraves, Héloise Michaud, Nicola McJannett, Bart Haegeman, Simon Fillatreau, Simon Fillatreau, Simon Fillatreau, Bernard Malissen, Georg Holländer, Georg Holländer, Georg Holländer, Saulius Žuklys, Jérémy C. Santamaria, Olivier P. Joffre, Paola Romagnoli, Joost P. M. van Meerwijk   +19 more
doaj   +1 more source

Gut Microbiota‐Butyrate‐PPARγ Axis Modulates Adipose Regulatory T Cell Population

Advanced Science, EarlyView.
This study identifies the indispensable role of gut microbiota in the maintenance of ST2+ adipose Treg cell population, and defines gut microbiota‐derived butyrate as an endogenous PPARγ agonist, modulating adipose Treg cell populations via promoting PPARγ activation. Butyrate or fiber supplementation restores the VAT ST2+ Treg population in obese mice
Banru Chen, Lizhi Guan, Chao Wu, Yiwen Gong, Lei Wu, Minchun Zhang, Zhiwen Cao, Yufei Chen, Chengcan Yang, Bing Wang, Yunqi Li, Bin Li, Yufang Bi, Guang Ning, Jiqiu Wang, Weiqing Wang, Ruixin Liu   +16 more
wiley   +1 more source