Results 61 to 70 of about 208,657 (313)

Inflammation and Thymus Ageing

, 2017
The thymus is primarily responsible for T cell production. However, it begins to recede in size and function, from early in life. This decreased generation of naive T cells during normal thymus ageing, or linked with pathology (i.e. chronic inflammation),
A. Alsharif, Ann P. Chidgey, Lepletier, A, Chidgey, Ann P, A. Lepletier, Alsharif, A   +5 more
core   +1 more source

Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development [PDF]

, 2011
Dendritic cells (DCs) in the thymus (tDCs) are predominantly accumulated in the medulla and contribute to the establishment of self-tolerance. However, how the medullary accumulation of tDCs is regulated and involved in self-tolerance is unclear. We show
Ishimaru, N., Hollander, G. A., Naozumi Ishimaru, Hayashi, Y., Rene de Waal Malefyt, Nitta, T., Yu Lei, Jeker, LT, Lei, Y., Jeker, L. T., Lei, Y, Georg A. Holländer, Ishimaru, N, Holländer, GA, Bösl, MR, Bosl, M. R., Yoshio Hayashi, Yousuke Takahama, Takahama, Y., Malefyt, RW, Michael R. Bösl, Lukas T. Jeker, Takeshi Nitta, Takahama, Y, Nagasawa, T., Nitta, T, Nagasawa, T, Izumi Ohigashi, Ripen, A. M., Hayashi, Y, Ohigashi, I., Malefyt, R. D., Takashi Nagasawa, Malefyt Rde, W., Ohigashi, I, Ripen, AM, Adiratna Mat Ripen   +36 more
core   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Immunodeficiency in DiGeorge Syndrome and Options for Treating Cases with Complete Athymia. [PDF]

, 2013
The commonest association of thymic stromal deficiency resulting in T-cell immunodeficiency is the DiGeorge syndrome (DGS). This results from abnormal development of the third and fourth pharyngeal arches and is most commonly associated with a ...
E. Graham Davies, Davies, EG, E Graham Davies   +2 more
core   +1 more source

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source

Neutrophil extracellular traps promote macrophage activation through Toll-like receptor engagement and PKA and NF-kB signaling pathways

Cell Communication and Signaling
Background Neutrophils play key roles in innate immune responses and can release extracellular traps (NETs), characterized by chromatin exteriorization associated with cytoplasmic and granule proteins, such as neutrophil elastase, myeloperoxidase, HMGB1,
Barbara Simonson Gonçalves, Jairo R. Temerozo, Andrés Mojoli, Natalia C. Rochael, Suwellen S. D. de Azevedo, Marcos Antonio Formiga-Jr, Gonzalo Bello, Marcelo Ribeiro-Alves, Elvira M. Saraiva, Dumith Chequer Bou-Habib   +9 more
doaj   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

THE REACTIVATED THYMUS [PDF]

Archives of Internal Medicine, 1917
"Persistent thymus" has been a term in the literature, though a term about which much skepticism has gathered. But it is gradually becoming established as a fact that the thymic parenchyma persists throughout life, and that this parenchyma may become reactivated to the extent that its secretion influences the endocrine equilibrium. The causes of such a
openaire   +2 more sources

Multi‐Omics Integration Identifies a CDH3‐Associated Malignant Epithelial State and Immunosuppressive Niche to Predict Prognosis in Thymic Epithelial Tumors

Advanced Science, EarlyView.
Single‐cell, spatial, molecular, and pathology analyses identify a CDH3‐associated malignant epithelial state in thymic epithelial tumors. This state links stem‐like and EMT programs to M2 macrophage–rich immunosuppressive niches, genomic instability, poor survival, and drug vulnerability.
Yuntao Feng, Jingyu Chen, Lang Xia, Tao Wang, Yuzhou Wang, Lei Zhang, Guofang Zhao, Long Xu, Juemin Yu, Yunlang She, Junqi Wu, Yue Zhao, Chang Chen, Deping Zhao   +13 more
wiley   +1 more source

Tissue adaptation of CD4 T lymphocytes in homeostasis and cancer

Frontiers in Immunology
The immune system is traditionally classified as a defense system that can discriminate between self and non-self or dangerous and non-dangerous situations, unleashing a tolerogenic reaction or immune response.
Marina V. A. Pereira, Marina V. A. Pereira, Rômulo G. Galvani, Triciana Gonçalves-Silva, Zilton Farias Meira de Vasconcelo, Adriana Bonomo   +5 more
doaj   +1 more source