Results 31 to 40 of about 191,183 (217)
Transforming growth factor-β signaling in thymic epithelial cells : its role in development, steady-state and immune reconstitution [PDF]
, 2010 The thymus constitutes the primary lymphoid organ responsible for the generation of naïve T cells. Its stromal compartment is composed of a scaffold of different subsets of epithelial cells that provide soluble and membrane-bound molecules essential for ...
Hauri-Hohl, Mathias Martin
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Frontiers in Endocrinology, 2018 T cell response plays an essential role in the host resistance to infection by the protozoan parasite Trypanosoma cruzi, the causative agent of Chagas disease.
Ana Rosa Pérez +8 more
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Metabolic Regulation of Thymic Epithelial Cell Function
Frontiers in Immunology, 2021 The thymus is the primary site of T lymphocyte development, where mutually inductive signaling between lymphoid progenitors and thymic stromal cells directs the progenitors along a well-characterized program of differentiation.
Manpreet K. Semwal +2 more
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Use of organ-culture, irradiation and adoptive-transfer to investigate the role of the xenopus thymus in t lymphocyte development [PDF]
, 1986 This Thesis attempts to develop an amphibian model system for exploring the role of the thymus, particularly its stromal cells, in the acquisition of allotolerance. Inbred, clonal and cytogenetically- marked Xenopus are used in this work.
Russ, Jane Hannah
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The role of the transcription factor Sox9 for thymic epithelial cell differentation and function [PDF]
, 2011 The thymus provides throughout life the specialized stromal microenvironment required for the lifelong generation of naïve T cells. This vital function is dependent on the regular composition and organization of its microenvironment, where specialized ...
Žalac, Tatjana
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CT density of cervical thymus, in comparison with mediastinal thymus
Insights into Imaging, 2019 Objectives Cervical component of thymus is noted more in children and young adults than in older age group. CT texture (lobules of soft tissue interspersed with fat), similarity with CT density of mediastinal thymus and continuity with mediastinal thymus
Anitha Sen, Jiji Valsalamony, Jubie Raj
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Frontiers in Immunology, 2021 Major Histocompatibility Complex (MHC) class II (MHCII) deficiency (MHCII-D), also known as Bare Lymphocyte Syndrome (BLS), is a rare combined immunodeficiency due to mutations in genes regulating expression of MHCII molecules.
Francesca Ferrua +41 more
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The role of neural crest cells in the development, organisation and migration of the thymus [PDF]
, 2010 Neural Crest (NC) derived mesenchyme has previously been shown to play an important role in the early development of the foetal thymus. Using Wnt1-Cre and Sox10-Cre mice crossed to Rosa26eYfp reporter mice, NC derived mesenchymal cells were revealed in
Foster, K.E.
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Indian hedgehog (Ihh) both promotes and restricts thymocyte differentiation [PDF]
, 2009 We show that Indian Hedgehog (Ihh) regulates T-cell development and homeostasis in both fetal and adult thymus, controlling thymocyte number. Fetal Ihh-/- thymi had reduced differentiation to double-positive (DP) cell and reduced cell numbers compared ...
Outram, Susan V +17 more
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eLife, 2020 The ability of the immune system to avoid autoimmune disease relies on tolerization of thymocytes to self-antigens whose expression and presentation by thymic medullary epithelial cells (mTECs) is controlled predominantly by Aire at the transcriptional ...
Clotilde Guyon +9 more
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