Results 11 to 20 of about 208,657 (313)

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T-Cell Immunity. [PDF]

Adv Sci (Weinh)
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Wang S, Zhang Z, Dai F, Yin Z, Xing Z, Li Y, Lei H, Zhang J, Liu C, Li Y, Dong L.   +10 more
europepmc   +2 more sources

Adenosine in the Thymus [PDF]

Frontiers in Pharmacology, 2017
Adenosine is an ancient extracellular signaling molecule that regulates various biological functions via activating four G-protein-coupled receptors, A1, A2A, A2B, and A3 adenosine receptors. As such, several studies have highlighted a role for adenosine signaling in affecting the T cell development in the thymus. Recent studies indicate that adenosine
Krisztina Köröskényi, Krisztina Köröskényi, Gergely Joós, Gergely Joós, Zsuzsa Szondy, Zsuzsa Szondy   +5 more
openaire   +3 more sources

Near-isotropic, reconstructed volume electron microscopy (FIB-SEM) of P7 mouse thymus (jrc_mus-thymus-1)

, 2023
Sample: Thymus tissue from a wild-type, postnatal day 7 mouse, strain: C57BL/6J from Jackson LabSample Description: A dataset featuring isotropic 3D electron microscopy data of the mouse thymus (jrc_mus-thymus-1). The sample was obtained from a wild-type
Stephan Preibisch (12975014), Zhiyuan Lu (11450573), Wei Qiu (9903656), Wei-Ping Li (14691662), Eric T. Trautman (6733172), CellMap Project Team (14322654)   +5 more
core   +1 more source

Chemical Composition of Essential Oilsof Thymus and Mentha Speciesand Their Antifungal Activities [PDF]

, 2009
The potential antifungal effects of Thymus vulgaris L., Thymus tosevii L., Mentha spicata L., and Mentha piperita L. (Labiatae) essential oils and their components against 17 micromycetal food poisoning, plant, animal and human pathogens are presented ...
Marin, P.D., Petar D. Marin, Vlatka Vajs, Dejan D. Brkić, Marin, Petar D, Jelena Vukojević, Vajs, V., Vajs, Vlatka E, van Griensven, L.J.L.D., Marin, Petar D., Brkić, Dejan, Marin, Petar, Brkić, Dejan D, Leo J. L. D. Van Griensven, Van Griensven, Leo J. L. D., Leo J. L. D. van Griensven, Vukojević, J, Brkić, D D, Griensven, L.J.L.D., van, Dejan D. Brkić, van Griensven, Leo JLD, Jelena Vukojević, Vukojević, Jelena B., Van Griensven, Leo J.L.D., Vukojevic,, J., Vajs, Vlatka, Sokovic,, M.D., Marina D. Soković, Marina D. Soković, Soković, Marina, Vukojević, Jelena, Brkic, D.D.   +31 more
core   +1 more source

The role of the transcription factor Foxn1 in Thymus organogenesis and maintenance [PDF]

, 2014
The thymus is the primary lymphoid organ responsible for T-cell development and selection, which requires a specialised stromal microenvironment. The thymic stroma consists mainly of thymic epithelial cells (TEC), which can be divided into cortical (c ...
Bosch, Angela Jeanne Tamara
core   +1 more source

Beta-selection: abundance of TCRbeta-/gammadelta- CD44- CD25- (DN4) cells in the foetal thymus. [PDF]

, 2007
Expression of TCRbeta and pre-TCR signalling are essential for differentiation of CD4- CD8- double negative (DN) thymocytes to the CD4+ CD8+ double-positive (DP) stage.
Outram, Susan V, Dessens, Johannes T, Nicola J. Rowbotham, Rowbotham, Nicola J, Tessa Crompton, Hager-Theodorides, Ariadne L, Ariadne L. Hager‐Theodorides, Susan V. Outram, Crompton, Tessa, Johannes T. Dessens   +9 more
core   +1 more source

Rapid progesterone actions on thymulin-secreting epithelial cells cultured from rat thymus [PDF]

, 1999
Many soluble factors of neural, endocrine, paracrine and autocrine origin are present in the thymus and modulate its function. Long-term effects of sex steroids have! been documented for thymocytes and cells of the thymic microenvironment. In this report
Downing, James E. G., Brucker, Cosima, Mentlein, Rolf, Kendall, Marion D., Head, Gail M.   +4 more
core   +1 more source

Thymus Atrophy and Double-Positive Escape Are Common Features in Infectious Diseases

Journal of Parasitology Research, 2012
The thymus is a primary lymphoid organ in which bone marrow-derived T-cell precursors undergo differentiation, leading to migration of positively selected thymocytes to the T-cell-dependent areas of secondary lymphoid organs.
Juliana de Meis, Désio Aurélio Farias-de-Oliveira, Pedro H. Nunes Panzenhagen, Naiara Maran, Déa Maria Serra Villa-Verde, Alexandre Morrot, Wilson Savino   +6 more
doaj   +1 more source

Impaired thymic iNKT cell differentiation at early precursor stage in murine haploidentical bone marrow transplantation with GvHD

Frontiers in Immunology, 2023
IntroductionEarly recovery of donor-derived invariant natural killer T (iNKT) cells are associated with reduced risk of graft-versus-host disease (GvHD) and overall survival.
Weijia Zhao, Yujia Wang, Xinwei Zhang, Jie Hao, Kunshan Zhang, Xiaojun Huang, Yingjun Chang, Hounan Wu, Rong Jin, Qing Ge, Qing Ge   +10 more
doaj   +1 more source

Function of Gata-2 in thymic epithelial cells : a transcription factor identified from gene expression analysis of endodermal cells committed to thymic epithelial cell fate [PDF]

, 2010
The thymus structure composes of clear morphological regions. The T-cell precursors enter the thymus in the cortico-medullary junction and migrate through the cortex towards the sub capsular region and back through to the cortex into the medulla.
Na, Kyung-Jae
core   +1 more source