Results 11 to 20 of about 162,919 (268)

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T-Cell Immunity. [PDF]

Adv Sci (Weinh)
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Wang S, Zhang Z, Dai F, Yin Z, Xing Z, Li Y, Lei H, Zhang J, Liu C, Li Y, Dong L.   +10 more
europepmc   +2 more sources

Adenosine in the Thymus [PDF]

Frontiers in Pharmacology, 2017
Adenosine is an ancient extracellular signaling molecule that regulates various biological functions via activating four G-protein-coupled receptors, A1, A2A, A2B, and A3 adenosine receptors. As such, several studies have highlighted a role for adenosine signaling in affecting the T cell development in the thymus. Recent studies indicate that adenosine
Krisztina Köröskényi, Krisztina Köröskényi, Gergely Joós, Gergely Joós, Zsuzsa Szondy, Zsuzsa Szondy   +5 more
openaire   +3 more sources

Thymus Atrophy and Double-Positive Escape Are Common Features in Infectious Diseases

Journal of Parasitology Research, 2012
The thymus is a primary lymphoid organ in which bone marrow-derived T-cell precursors undergo differentiation, leading to migration of positively selected thymocytes to the T-cell-dependent areas of secondary lymphoid organs.
Juliana de Meis, Désio Aurélio Farias-de-Oliveira, Pedro H. Nunes Panzenhagen, Naiara Maran, Déa Maria Serra Villa-Verde, Alexandre Morrot, Wilson Savino   +6 more
doaj   +1 more source

Impaired thymic iNKT cell differentiation at early precursor stage in murine haploidentical bone marrow transplantation with GvHD

Frontiers in Immunology, 2023
IntroductionEarly recovery of donor-derived invariant natural killer T (iNKT) cells are associated with reduced risk of graft-versus-host disease (GvHD) and overall survival.
Weijia Zhao, Yujia Wang, Xinwei Zhang, Jie Hao, Kunshan Zhang, Xiaojun Huang, Yingjun Chang, Hounan Wu, Rong Jin, Qing Ge, Qing Ge   +10 more
doaj   +1 more source

Neuroendocrine Control of Macrophage Development and Function

Frontiers in Immunology, 2018
Macrophages carry out numerous physiological activities that are essential for both systemic and local homeostasis, as well as innate and adaptive immune responses. Their biology is intricately regulated by hormones, neuropeptides, and neurotransmitters,
Arnon Dias Jurberg, Arnon Dias Jurberg, Vinícius Cotta-de-Almeida, Vinícius Cotta-de-Almeida, Jairo Ramos Temerozo, Jairo Ramos Temerozo, Wilson Savino, Wilson Savino, Dumith Chequer Bou-Habib, Dumith Chequer Bou-Habib, Ingo Riederer, Ingo Riederer   +11 more
doaj   +1 more source

A novel, ataxic mouse model of ataxia telangiectasia caused by a clinically relevant nonsense mutation

eLife, 2021
Ataxia Telangiectasia (A-T) and Ataxia with Ocular Apraxia Type 1 (AOA1) are devastating neurological disorders caused by null mutations in the genome stability genes, A-T mutated (ATM) and Aprataxin (APTX), respectively.
Harvey Perez, May F Abdallah, Jose I Chavira, Angelina S Norris, Martin T Egeland, Karen L Vo, Callan L Buechsenschuetz, Valentina Sanghez, Jeannie L Kim, Molly Pind, Kotoka Nakamura, Geoffrey G Hicks, Richard A Gatti, Joaquin Madrenas, Michelina Iacovino, Peter J McKinnon, Paul J Mathews   +16 more
doaj   +1 more source

Chemical composition of essential oil for Thymus population from Albania

Zaštita Materijala, 2020
This study presents data about chemical composition of essential oils for Thymus populations from the Albania. The genus Thymus contains about 350 species of aromatic plants in the family Lamiaceae.
Jonida Salihila, Dorina Shengjergji, Dhimiter Peci, Aida Dervishi   +3 more
doaj   +1 more source

Oral Versus Intragastric Inoculation: Similar Pathways of Trypanosoma cruzi Experimental Infection? From Target Tissues, Parasite Evasion, and Immune Response

Frontiers in Immunology, 2018
Currently, oral infection is the most frequent transmission mechanism of Chagas disease in Brazil and others Latin American countries. This transmission pathway presents increased mortality rate in the first 2 weeks, which is higher than the calculated ...
Juliana Barreto de Albuquerque, Danielle Silva dos Santos, Jens V. Stein, Juliana de Meis, Juliana de Meis   +4 more
doaj   +1 more source

Oral Route Driven Acute Trypanosoma cruzi Infection Unravels an IL-6 Dependent Hemostatic Derangement

Frontiers in Immunology, 2019
Oral transmission of Trypanosoma cruzi, the etiologic agent of Chagas disease, is presently the most important route of infection in Brazilian Amazon.
Dina Antunes, Dina Antunes, Alessandro Marins-Dos-Santos, Alessandro Marins-Dos-Santos, Mariana Tavares Ramos, Mariana Tavares Ramos, Barbara Angelica S. Mascarenhas, Barbara Angelica S. Mascarenhas, Carlos José de Carvalho Moreira, Désio Aurélio Farias-de-Oliveira, Désio Aurélio Farias-de-Oliveira, Wilson Savino, Wilson Savino, Robson Q. Monteiro, Juliana de Meis, Juliana de Meis   +15 more
doaj   +1 more source

The Neuropeptides Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase-Activating Polypeptide Control HIV-1 Infection in Macrophages Through Activation of Protein Kinases A and C

Frontiers in Immunology, 2018
Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) are highly similar neuropeptides present in several tissues, endowed with immunoregulatory functions and other systemic effects.
Jairo R. Temerozo, Jairo R. Temerozo, Suwellen S. D. de Azevedo, Daniella B. R. Insuela, Rhaíssa C. Vieira, Pedro L. C. Ferreira, Vinícius F. Carvalho, Vinícius F. Carvalho, Gonzalo Bello, Dumith Chequer Bou-Habib, Dumith Chequer Bou-Habib   +10 more
doaj   +1 more source