Results 131 to 140 of about 409,890 (320)

Multicentric lymphomas in goats (Capra hircus): Clinical manifestations, therapeutic modalities and pathological characteristics

Veterinary Record Case Reports, EarlyView.
Abstract Two cases of sporadic multicentric lymphomas with mediastinal masses in goats are documented. The first case involved a 3.5‐year‐old male goat. Ultrasound imaging revealed an enlarged right perirenal lymph node, which was confirmed as lymphoma through incisional biopsy and cytopathological analysis. Despite treatment, the goat succumbed to the
Angélica Consalter, Mateus de Melo Lima Waterloo, Juliana Mariotti Guerra, Ana Maria Reis Ferreira, Juliana da Silva Leite, Kassia Valéria Gomes Coelho da Silva, Mário Felipe Alvarez Balaro   +6 more
wiley   +1 more source

Age‐Related Oxidative Stress and Mitochondrial Dysfunction in Lymph Node Stromal Cells Limit the Peripheral T Cell Homeostatic Maintenance and Function

Aging Cell, EarlyView.
Aging of the lymph node stromal cells limits their ability to support the survival and maintenance of peripheral naive T cells. The lymph node stromal cells are critical for providing the survival and trophic signals to peripheral naïve T cells, and after the early‐life thymic involution, these secondary lymphoid organ stromal microniches are decisive ...
Sandip Ashok Sonar, Ruchika Bhat, Heather L. Thompson, Christopher P. Coplen, Jennifer L. Uhrlaub, Mladen Jergovic, Janko Ž. Nikolich   +6 more
wiley   +1 more source

[Thymus neoplasms associated with myasthenia gravis].

Nowotwory, 1975
John Nowicki, Thomas J. Otto
openalex   +2 more sources

Understanding the Variability of Peanut‐Oral Immunotherapy Responses by Multi‐Omics Profiling of Immune Cells

Allergy, EarlyView.
This study analyzes molecular drivers of OIT responsiveness. Multi‐omics profiling of peanut‐stimulated PBMCs in a controlled peanut‐OIT trial identifies immune, transcriptomic, and epigenetic changes distinguishing complete responders from incomplete responders. Key findings highlight gastrointestinal immune mechanisms, including extracellular exosome
Aleix Arnau‐Soler, Sarah E. Ashley, Ahla Ghauri, Alexander C. S. N. Jeanrenaud, Ingo Marenholz, Katharina Blumchen, Penelope Cibin, Alisa Iakupova, Norbert Hubner, Kirsten Beyer, Young‐Ae Lee   +10 more
wiley   +1 more source

Identification of MEF2A, MEF2C, and MEF2D interactomes in basal and Fsk‐stimulated mouse MA‐10 Leydig cells

Andrology, EarlyView.
Abstract Background Myocyte enhancer factor 2 transcription factors regulate essential transcriptional programs in various cell types. The activity of myocyte enhancer factor 2 factors is modulated through interactions with cofactors, chromatin remodelers, and other regulatory proteins, which are dependent on cell context and physiological state.
Karine de Mattos, Marie‐Pier Scott‐Boyer, Arnaud Droit, Robert S. Viger, Jacques J. Tremblay   +4 more
wiley   +1 more source

Co‐operative epigenetic remodelling by Setd2 deficiency and Kras mutation drives juvenile myelomonocytic leukaemia development and MEK inhibitor sensitivity

British Journal of Haematology, EarlyView.
A proposed model of Setd2 deficiency and KrasG12D/+ mutation synergism in the pathogenesis of juvenile myelomonocytic leukaemia (JMML). KrasG12D/+ mutation instigates constitutive activation of the RAS‐ERK1/2 signalling pathway, and Setd2 ablation in the KrasG12D/+ mutant background further hyperactivates the RAS‐ERK1/2 signalling pathway, leading to ...
Gustave Munyurangabo, Linlin Zhang, Ying Zhou, Peihua Zhang, Xiao Yu, Dou Qu, Dan Yang, Xiaomin Ren, Hongwei Liu, Yonghong Wu, Guangyao Kong, Yi Yang   +11 more
wiley   +1 more source

Взгляды на некоторые дискуссионные проблемы этиопатогенеза и классификации органоспецифических новообразований вилочковой железы [PDF]

, 2003
Представлены современные воззрения на классификацию, терминологические определения различных опухолей и опухолевидных образований вилочковой железы с учетом их морфологических, генетических, иммунологических, гормональных показателей. Приводятся факторы,
Флорикян, А.К.
core  

The impact of Foxp3+ regulatory T‐cells on CD8+ T‐cell dysfunction in tumour microenvironments and responses to immune checkpoint inhibitors

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have been a breakthrough in cancer therapy, inducing durable remissions in responding patients. However, they are associated with variable outcomes, spanning from disease hyperprogression to complete responses with the onset of immune‐related adverse events.
Mikhaël Attias, Ciriaco A. Piccirillo
wiley   +1 more source

Treatment options for immune‐related adverse events associated with immune checkpoint inhibitors

British Journal of Pharmacology, EarlyView.
Abstract The immunotherapy revolution with the use of immune checkpoint inhibitors (ICIs) started with the clinical use of the first ICI, ipilimumab, in 2011. Since then, the field of ICI therapy has rapidly expanded — with the FDA approval of 10 different ICI drugs so far and their incorporation into the therapeutic regimens of a range of malignancies.
Yu Hua Chen, Tamás Kovács, Péter Ferdinandy, Zoltán V. Varga   +3 more
wiley   +1 more source

Monovalent glycoconjugates of sulforaphane prevent inflammation induced by lipopolysaccharide in human dendritic cells by inhibiting NF‐ĸB signalling pathway

British Journal of Pharmacology, EarlyView.
Background and Purpose Sulforaphane (SFN) has notable health benefits but faces challenges due to its poor solubility and delivery. This study investigates SFN‐glycoconjugates effects on lipopolysaccharide (LPS)‐induced inflammation in dendritic cells (DCs). With the aiming to enhance their therapeutic potential against inflammatory diseases.
Camila Leiva‐Castro, Ana Maria Múnera‐Rodríguez, Macarena Martínez‐Bailén, Ana Teresa Carmona, Soledad López‐Enríquez, Francisca Palomares   +5 more
wiley   +1 more source