Results 171 to 180 of about 600,981 (261)

Western Diet Combined With Chemical Induction: A Strategy for Rapid Development of MASLD Pathology in Mice

open access: yesiNew Medicine, Volume 2, Issue 3, September 2026.
ABSTRACT Objective The molecular mechanisms underlying the development of metabolic‐dysfunction‐associated steatotic liver disease (MASLD) are essential for developing appropriate treatments. The purpose of this study was to establish an MASLD model in mice with rapid and consistent progression.
Ting‐Ting Chen   +10 more
wiley   +1 more source

Carvacrol Mitigates TNF‐α‐Driven Oxidative and Bioenergetic Impairment in L6 Rat Myoblasts

open access: yesJournal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
Carvacrol (6.25 µg/mL) attenuates TNF‐α‐induced bioenergetic toxicity in L6 rat myoblasts by reducing LDH release by 79%, quenching intracellular ROS, partially restoring mitochondrial membrane potential and ion‐dependent ATPase activities, recovering catalase and SOD function, and upregulating SIRT1 and AMPK mRNA—identifying carvacrol as a multi ...
Ali M. Albarrati, Rakan I. Nazer
wiley   +1 more source

Thymus and Leishmania at the Crossroads: Autoimmunity and Cancer. [PDF]

open access: yesImmunology
Barros ABB   +5 more
europepmc   +1 more source

Exploring the Differential Impact of Melatonin Timing Administration (Day vs. Night) on Mitigating Cerebellar Damage Caused by Monosodium Glutamate in Rats

open access: yesJournal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
Exogenous melatonin, especially when given at night, provides strong neuroprotective benefits by influencing circadian serum melatonin levels. It inhibits PI3K‐dependent inflammatory signaling and encourages the nuclear translocation of NRF2, along with activation of the NRF2/HO‐1 antioxidant pathway.
Alaa Gamal Ahmad   +4 more
wiley   +1 more source

Autoimmunity: Molecular Mechanisms, Biomarkers, and Therapeutic Opportunities

open access: yesMedComm, Volume 7, Issue 9, September 2026.
Major types of immunometabolism, epigenetics, posttranscriptional regulation, and functional reprogramming involved in autoimmune diseases. The roles of immunometabolism, epigenetics, posttranscriptional regulation, and functional reprogramming in autoimmune diseases have been a major research focus in recent years.
Jialong Kuang   +10 more
wiley   +1 more source

Abscopal Effect in Radiation Therapy: The Immune Mechanisms and Clinical Advances

open access: yesMedComm, Volume 7, Issue 9, September 2026.
The schematic outlines the key events of the abscopal effect. (Ignition) Local radiotherapy (RT) induces the release of immunogenic signals from the tumor, leading to dendritic cell (DC) activation. (Orchestration) In the tumor‐draining lymph node (TDLN), DCs prime naive T cells into cytotoxic T lymphocytes (CTLs), a process modulated by regulatory T ...
Yihong Dong   +5 more
wiley   +1 more source

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