Results 181 to 190 of about 409,890 (320)

Generation of Regulatory T Cells From Human Memory CD4+T Cells by Upregulation of Naked Cuticle Homolog 2

European Journal of Immunology, Volume 55, Issue 8, August 2025.
This study discovered the small molecule 9‐methoxy‐6‐methylindolo[3,2‐b] quinoxaline (IFA005) as a potent immunomodulator capable of converting human memory CD4⁺ T cells into functional Foxp3⁺ regulatory T cells. IFA005 suppresses Th2 cytokines (IL‐4, IL‐5, and IL‐13) and promotes the iTreg phenotype by inhibiting Wnt/β‐catenin signaling through NKD2 ...
Jiajun He, Kristy Ou, Michael Schmueck‐Henneresse, Edgar Specker, Jérôme Paul, Marc Nazare, Jens Peter von Kries, Julia K. Polansky, Alf Hamann, Stefan Frischbutter   +9 more
wiley   +1 more source

A case report of primary mucinous adenocarcinoma of the thymus and review of the literature. [PDF]

J Surg Case Rep
Xu P, Jiang H, Zheng F, Song Q.
europepmc   +1 more source

Dietary Carvacrol Attenuates Cyclophosphamide‐Induced Neurotoxicity: Implications for Food‐Derived Neuroprotection and Molecular Mechanisms

Food Science &Nutrition, Volume 13, Issue 8, August 2025.
Carvacrol, a compound found in herbs like oregano and thyme, shows promise in protecting against cyclophosphamide‐induced neurotoxicity in rats by reducing oxidative stress, inflammation, and cell death, and by preserving cognitive function. ABSTRACT Carvacrol (CRV) is a phenolic monoterpene abundant in culinary herbs such as oregano and thyme and is ...
Hamit Emre Kızıl
wiley   +1 more source

A case of diagnosis and treatment of mediastinal Langerhans cytosis. [PDF]

J Cardiothorac Surg
Niu Y, Xian L, Wang Y, Chen Y, Lu Y, Liang D.   +5 more
europepmc   +1 more source

PI3K/AKT/mTOR Axis in Cancer: From Pathogenesis to Treatment

MedComm, Volume 6, Issue 8, August 2025.
The PI3K/AKT/mTOR signaling axis is crucial in cancer progression, regulating cell growth, survival, and metabolism. Often hyperactivated through mutations or loss of tumor suppressors such as PTEN, this pathway promotes cancer cell proliferation and survival by inhibiting apoptosis and activating mTOR, which drives protein synthesis and suppresses ...
Mingyang Jiang, Ke Zhang, Zhenwang Zhang, Xinran Zeng, Zihang Huang, Peizhuo Qin, Zhilin Xie, Xue Cai, Milad Ashrafizadeh, Yu Tian, Ruqiong Wei   +10 more
wiley   +1 more source

Thymic characteristics in patients with autoimmune diseases: a multicentre radiological observational study. [PDF]

Lancet Reg Health West Pac
Chang H, Yan J, Wang A, Wang N, Liu P, Shi Y, Zhao X, Zhu J, Cai Y, Xia X, Hao Y, Yin S, Wang J, Wang X, Sun L, Ma J, Huang X, Guan H, Tian DC, Shi K, Du G, Huang W, Qi G, Li H, Wang Y, Shi FD, Zhang Z, Jin WN.   +27 more
europepmc   +1 more source

T Cell‐Specific Deficiency of Src Homology 2‐Containing Protein Tyrosine Phosphatase 2 Ameliorates Psoriasis and Colitis by Promoting Treg Differentiation

MedComm, Volume 6, Issue 8, August 2025.
• SHP2 deficiency in T cells could alleviate both psoriasis‐like skin lesion and adoptive transfer colitis. • SHP2 deficiency in T cells promotes the differentiation toward Treg, thus regulating the balance of Th17/Treg. • SHP2 may become a promising common therapeutic target in the treatment of autoimmune diseases.
Shuqiong Zhang, Zijun Ouyang, Zhidan Fan, Haiyan Sun, Haiguo Yu, Xingxin Wu, Yang Sun, Fenli Shao   +7 more
wiley   +1 more source

Ferroptosis mediated by the IDO1/Kyn/AhR pathway triggers acute thymic involution in sepsis. [PDF]

Cell Death Dis
Cheng Z, Wang K, Wang Y, Liu T, Li J, Wang Y, Chen W, Awuti R, Zhou H, Tong W, Yu Z, Wang Y, Su G, Yang W, Zhou Y, Lu G, Zhang C.   +16 more
europepmc   +1 more source

Interplay between inflammatory reflex and energetic metabolism in endotoxaemia: A role for haem oxygenase 1?

British Journal of Pharmacology, Volume 182, Issue 16, Page 3695-3709, August 2025.
Inflammation is vital for defence against injury and infection, but excessive inflammation can lead to tissue damage and disease. The central nervous system (CNS) helps regulate immune responses through neuroendocrine pathways, such as the hypothalamic–pituitary–adrenal axis and the anti‐inflammatory reflex, which limit systemic inflammation.
Evelin C. Cárnio, Luiz G. S. Branco, Fernanda Brognara, Patrícia Passaglia, Roberta Foresti, Roberto Motterlini   +5 more
wiley   +1 more source

Surgical approaches for thymectomy: a narrative review. [PDF]

Mediastinum
Vaidya Y, Polycarpou A, Gibbs S, Rao M, Bhargava A, Andrade R, Diaz-Gutierrez I.   +6 more
europepmc   +1 more source