Results 51 to 60 of about 136,384 (208)

Optimizing Cancer Vaccinations Using a Physiologically‐Based Pharmacokinetic/Pharmacodynamic (PBPK/PD) Model

Advanced Science, EarlyView.
Where and when should a cancer vaccine be administered? A whole‐body PBPK model demonstrates that systemic immune transport critically determines vaccination efficacy. By simulating how organ‐specific immune interactions influence treatment response, the study provides a quantitative framework for optimizing cancer vaccination strategies.
Mohammad R. Nikmaneshi, Timothy P. Padera, Lance L. Munn   +2 more
wiley   +1 more source

Serous Neoplasms

, 2014
Although interest in pancreatic pathology is very high in the radiological and gastroenterological communities, it is still the case that less is known about pathology of the pancreas than about liver pathology, for example.
Paolo Tinazzi Martini, Giovanni Morana, Stefano Canestrini, Riccardo De Robertis, Roberto Pozzi Mucelli, Paola Capelli, Stefano Gobbo, Mirko D’Onofrio, Claudio Luchini, D’Onofrio Mirko, De Robertis Riccardo, Luchini Claudio, Canestrini Stefano, Gobbo Stefano, Mucelli Roberto Pozzi, Capelli Paola, Martini Paolo Tinazzi, Morana Giovanni   +17 more
core   +2 more sources

Treatment of ACTH-ectopic syndrome with long-acting octreotide: effective control of disease activity

Ожирение и метаболизм, 2022
ACTH — ectopic syndrome (ACTH-ES) is a severe multisystem disease caused by paraneoplastic secretion of ACTH itself and/or much less often corticoliberin (CL) by tumor tissue.
R. M. Guseinova, E. A. Pigarova, L. K. Dzeranova, M. S. Sheremeta, E. G. Przhiyalkovskaya   +4 more
doaj   +1 more source

A Dual‐Functional Nanoplatform Targeting the dsDNA–cGAS Axis to Mitigate Disc Degeneration and Aberrant Innervation

Advanced Science, EarlyView.
RU@PEI‐ZIF integrates dsDNA scavenging with local cGAS inhibition to suppress the dsDNA–cGAS–STING/Netrin‐1 axis in intervertebral disc degeneration. By attenuating nucleus pulposus cell senescence, inflammatory and matrix‐catabolic responses, and pathological sensory innervation, this dual‐functional nanoplatform preserves disc integrity and reduces ...
Zhaojun He, Tianyu Chen, Zezheng Liu, Xinlin Huang, Ruitangbin Jiang, Yihao Liu, Baojing Xu, Yuxiang Li, Kangning Zhao, Huibo Yan, Lei Zhou, Can Liu, Qingchu Li   +12 more
wiley   +1 more source

Primary Mesenteric Carcinoid Tumor Presenting with Carcinoid Syndrome

Case Reports in Gastroenterology, 2018
Neuroendocrine neoplasms (NENs) are a diverse group of tumors arising throughout the body with a common origin from neuroendocrine cells. Well-differentiated NENs, also known as neuroendocrine tumors (NETs), are generally indolent and are often found ...
Oluwaseun Shogbesan, Abdullateef Abdulkareem, Binu Pappachen, John Altomare   +3 more
doaj   +1 more source

Comparative Evaluation of Chelator‐Conjugated Peptides for Lead‐Labeled SSTR2‐Targeted Theranostics: Integrated Computational Modeling and Preclinical Validation

Advanced Science, EarlyView.
The study integrates density functional theory with radiochemical and biological validation to compare DOTA‐, PSC‐, and DOTAM‐based chelator‐conjugates for 203Pb/212Pb theranostic applications. Distinct differences in metal coordination, electrostatic properties, conformational flexibility, cellular uptake, biodistribution, and dosimetry are identified
Jeongyun Kim, Na Yeon Han, Ayman Muzammal, Jae Hun Ahn, Changkeun Im, Sujin Kim, Sairan Eom, Choong Mo Kang, Ku Kang, Yong Jin Lee, Kyo Chul Lee, Michael K. Schultz, Dongyoul Lee   +12 more
wiley   +1 more source

A rare case of tumor‐to‐tumor metastasis from thymic carcinoma to an ovarian mature teratoma

Thoracic Cancer
Metastasis from one neoplasm to another is referred to as tumor‐to‐tumor metastasis (TTM). TTM is rarely observed. Here, we present a patient with TTM from a thymic carcinoma to an ovarian mature teratoma. A 25‐year‐old woman, diagnosed with unresectable
Tsuyoshi Sasada, Chigusa Shirakawa, Ryo Tachikawa, Daisuke Yamashita, Keisuke Tomii   +4 more
doaj   +1 more source

Calcified multilocular thymic cyst associated with thymoma: a case report

Journal of Medical Case Reports, 2011
Introduction There are few case reports of thymoma with a thymic cyst. Such an association renders it difficult for any pathologist to differentiate from other neoplasms, such as a cystic thymoma. Case presentation A 50-year-old Berber woman from Morocco
Laraqui Laila, Jahid Ahmed, Zouaidia Fouad, Elouazzani Hafsa, Bernoussi Zakiya, Mahassini Najat   +5 more
doaj   +1 more source

Plasma Membrane Lipid Asymmetry Dynamically Regulates Passive Diffusion

Advanced Science, EarlyView.
Passive diffusion enables hydrophobic molecules to cross the plasma membrane and exert their biological functions. This study demonstrates that plasma membrane lipid asymmetry, dynamically regulated by lipid scrambling, determines membrane permeability to lipophilic molecules and thereby modulates their cellular activities.
Jieming Ping, Wenliang Wang, Jinnuo Xu, Mengyun Yang, Ning Wu   +4 more
wiley   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source