Results 61 to 70 of about 45,884 (303)

Endocrine Disorders as a Contributory Factor to Neoplasia in SJL/J Mice [PDF]

, 2017
We studied the endocrine status of SJL/J mice. Light and electron microscopy revealed that the adenohypophyses of both sexes became progressively infiltrated with an abnormal number of gonadotropinproducing cells that probably secreted large amounts of ...
Bianchi, E., Bree, M., Haran-Ghera, N., Meshorer, A., Müller, J., Pierpaoli, W.   +5 more
core  

Fine needle aspiration cytology of hepatic metastases of neuroendocrine tumors: A 20‐year retrospective, single institutional study [PDF]

, 2017
Background Fine needle aspiration (FNA) is considered an excellent technique for documenting metastatic neuroendocrine tumors (NETs). This study aims to evaluate the accuracy of FNA in diagnosing metastatic NETs to the liver and determining the grade ...
Cramer, Harvey, Saeed, Omer A., Wang, Xiaoyan, Wu, Howard H.   +3 more
core   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Metastatic Thymic Mucoepidermoid Carcinoma: The Diagnostic Challenges and Role of CRTC1/MAML2 Translocation in Accurate Diagnosis and Treatment

Thoracic Cancer
Mucoepidermoid carcinoma (MEC) is a subtype of epithelial neoplasms commonly found in salivary glands, but can also be seen in the thymus. Diagnosing MEC of the thymus is sometimes challenging due to its histological similarities with adenosquamous ...
Toshiaki Takahashi, Daniel Graham, Evan Wu   +2 more
doaj   +1 more source

Aspects of thymic pathologies in paediatric patients. Case study of true thymic hyperplasia and the diagnostic approach

Pediatria Polska
Proliferative lesions of the thymus are very rare in children and represent about 2% of mediastinal tumours. They may result from organ hyperplasia, the presence of cysts, or germinal and epithelial neoplasms.
Aleksandra Wietecha-Pikul, Agnieszka Juranek, Ewa Cichocka-Jarosz, Izabella Głodzik, Wojciech Górecki, Edyta Juraszewska, Aleksandra Kiszka-Wiłkojć, Grzegorz Lis, Anna Taczanowska-Niemczuk, Przemko Kwinta   +9 more
doaj   +1 more source

Treatment of ACTH-ectopic syndrome with long-acting octreotide: effective control of disease activity

Ожирение и метаболизм, 2022
ACTH — ectopic syndrome (ACTH-ES) is a severe multisystem disease caused by paraneoplastic secretion of ACTH itself and/or much less often corticoliberin (CL) by tumor tissue.
R. M. Guseinova, E. A. Pigarova, L. K. Dzeranova, M. S. Sheremeta, E. G. Przhiyalkovskaya   +4 more
doaj   +1 more source

The Evolving Role of CD8+CD28- Immunosenescent T Cells in Cancer Immunology [PDF]

, 2019
Functional, tumor-specific CD8+ cytotoxic T lymphocytes drive the adaptive immune response to cancer. Thus, induction of their activity is the ultimate aim of all immunotherapies.
Dey, Mahua, Fetcko, Kaleigh, Henriquez, Mario, Huff, Wei X., Kwon, Jae Hyun   +4 more
core   +1 more source

A Microbiota‐ and IL‐15‐Dependent Innate‐Like B Cell Progenitor Expressing E4BP4

Advanced Science, EarlyView.
This work identifies CD3.NKp46.CD19.NK1.1. NK‐B cells enriched in PDK1‐deficient yet present in wild‐type bone marrow. IL‐15 (via CD122) and TLR9‐microbiota signaling maintain their E4BP4 expression. These cells demonstrate innate immunity, preferentially differentiate into B cells, and unveil a novel microbiota‐ and IL‐15‐dependent regulatory pathway ...
Junming He, Xinlei Hou, Xiaomei Feng, Yayun Dong, Mengqi Ren, Surong Deng, Xinru Yang, Donglin Chen, Lingna Zhao, Shasha Chen, Meixiang Yang, Zhongjun Dong   +11 more
wiley   +1 more source

Primary Mesenteric Carcinoid Tumor Presenting with Carcinoid Syndrome

Case Reports in Gastroenterology, 2018
Neuroendocrine neoplasms (NENs) are a diverse group of tumors arising throughout the body with a common origin from neuroendocrine cells. Well-differentiated NENs, also known as neuroendocrine tumors (NETs), are generally indolent and are often found ...
Oluwaseun Shogbesan, Abdullateef Abdulkareem, Binu Pappachen, John Altomare   +3 more
doaj   +1 more source

Gauging NOTCH1 Activation in Cancer Using Immunohistochemistry [PDF]

, 2013
Fixed, paraffin-embedded (FPE) tissues are a potentially rich resource for studying the role of NOTCH1 in cancer and other pathologies, but tests that reliably detect activated NOTCH1 (NICD1) in FPE samples have been lacking.
Ashworth, Todd, Aster, Jon C., Brock, Jane E., Cassidy, Andrew J., Chirieac, Lucian R., Cho, Raymond J., DeAngelo, Daniel J., Dillon, Deborah, Dorfman, David, Haines, Brian B., Hirsch, Michelle, Hornick, Jason L., Kluk, Michael J., Knoechel, Birgit, Krop, Ian E., Lazar, Alexander J. F., Leigh, Irene M., Mason, Emily F., Morgan, Elizabeth A., Oh, David J., Peto, Myron, Pinkus, Geraldine, Pourreyron, Celine, Rodig, Scott, Sathayanrayanan, Sriram, South, Andrew P., Stoeck, Alexander, Wang, Hongfang, Weigert, Oliver, Weinstock, David M.   +29 more
core   +2 more sources