Targeting DLL4 in tumors shows preclinical activity but potentially significant toxicity. [PDF]
, 2010 Evaluation of: Yan M, Callahan CA, Beyer JC et al.: Chronic DLL4 blockade induces vascular neoplasms. Nature 463, E6-E7 (2010). Delta-like ligand 4 (DLL4) is a Notch ligand that is critical in the formation of a functional vascular network in tumors ...
Adrian L Harris +11 more
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Three potential sources of cell injuries of lymphoid cells associated with developments of lymphoid leukemia and lymphoma [PDF]
arXiv, 2018 Lymphoid leukemia (LL) and lymphoma are blood cancers developed from lymphoid cells (LCs). To understand the cause and the mechanism of cell transformation of a LC, we studied the potential sources of cell injuries of LCs and analyzed how DNA changes are generated and accumulate in LCs. I.
arxiv
Dynamics of T Cell Receptor Distributions Following Acute Thymic Atrophy and Resumption [PDF]
arXiv, 2019 Naive human T cells are produced in the thymus, which atrophies abruptly and severely in response to physical or psychological stress. To understand how an instance of stress affects the size and "diversity" of the peripheral naive T cell pool, we derive a mean-field autonomous ODE model of T cell replenishment that allows us to track the clone ...
arxiv
Mouse models of colorectal cancer. [PDF]
, 2011 Colorectal cancer is one of the most common malignancies in the world. Many mouse models have been developed to evaluate features of colorectal cancer in humans. These can be grouped into genetically-engineered, chemically-induced, and inoculated models.
Koeffler, H Phillip +2 more
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On tumor development: fractional transport approach [PDF]
arXiv, 2004 A growth of malignant neoplasm is considered as a fractional transport approach. We suggested that the main process of the tumor development through a lymphatic net is fractional transport of cells. In the framework of this fractional kinetics we were able to show that the mean size of main growth is due to subdiffusion, while the appearance of ...
arxiv
Explainable machine learning for neoplasms diagnosis via electrocardiograms: an externally validated study [PDF]
arXivBackground: Neoplasms remains a leading cause of mortality worldwide, with timely diagnosis being crucial for improving patient outcomes. Current diagnostic methods are often invasive, costly, and inaccessible to many populations. Electrocardiogram (ECG) data, widely available and non-invasive, has the potential to serve as a tool for neoplasms ...
arxiv
Reconstruction of continuous series of mortality by cause of death in West Germany for the years 1968-1997 [PDF]
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Markéta Pechholdová
core
Spindle Epithelial Tumor with Thymus-Like Differentiation (SETTLE): A Distinctive Malignant Thyroid Neoplasm with Significant Metastatic Potential [PDF]
, 2000 Wah Cheuk +2 more
openalex +1 more source
Perspective: Speculative role of Tmp21 mediated protein secretory pathway during endoplasmic reticulum (ER) stress induced chronic inflammation [PDF]
arXiv, 2016 By deploying myelofibrosis as the disease context, I wish to propose that increased availability of Tmp21 (an NFAT gene target) induces aberrant protein secretion from the ER contributing to pathological consequences, which has not been elucidated before.
arxiv
[Thymus neoplasms associated with myasthenia gravis].
Nowotwory, 1975 John Nowicki, Thomas J. Otto
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