Results 91 to 100 of about 583,270 (252)

Hashimoto’s thyroiditis and thyroid hormone sensitivity in euthyroid individuals: their association with carotid plaque in northeast China

Frontiers in Endocrinology
BackgroundCarotid plaque is a hallmark of systemic atherosclerosis, which underlies the pathology of cardiovascular and cerebrovascular events. Both thyroid hormones and Hashimoto’s thyroiditis (HT) affect carotid plaque formation, but their impact on ...
Yanmeizhi Wu, Jingxue Sun, Yanan Ni, Minnan Wang, Hong Qiao, Hong Qiao   +5 more
doaj   +1 more source

ZMIZ2–DUX4–LGR5 Signaling Axis Maintains Stemness Properties and Facilitates Docetaxel Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study identifies ZMIZ2 as a therapeutic target for docetaxel‐resistant triple‐negative breast cancer, sustaining cancer stemness‐associated properties and docetaxel resistance. ZMIZ2 upregulation enhances DUX4‐mediated LGR5 activation through the SWI/SNF components BRG1 and BAF57.
Xueting Gan, Shulei Sun, Ran Hu, Yuheng Feng, Xinhao Wu, Fangqi Liu, Xuyong Lin, Xiupeng Zhang, Xuezhu Rong, Qiang Han   +9 more
wiley   +1 more source

Case study: Thyrotoxicosis on women with complete hydatidiform molar pregnancy

JKKI (Jurnal Kedokteran dan Kesehatan Indonesia), 2019
Thyrotoxicosis defined as a clinical manifestation of excess circulating thyroid hormone. Epidemiologic investigation reports 0.2% of thyrotoxicosis is caused by hydatidiform mole.
Gagah Baskara Adi Nugraha, Pugud Samodro
doaj   +1 more source

Lactate Drives Pathological Browning of White Adipose Tissue to Aggravate Sepsis‐Associated Metabolic Disorders in a GPR81‐Dependent Manner

Advanced Science, EarlyView.
Sepsis‐triggered lactate accumulation induces pathological white adipose tissue browning. Lactate activates adipocyte GPR81 to sequentially upregulate CTRP6‐p38 signalling and UCP1 expression. This cascade exacerbates sepsis‐associated metabolic disorders.
Chunliang Zheng, Xiaohua Li, Shuo Li, Chungen Xing, Chun Cao   +4 more
wiley   +1 more source

Thyroid Hormone Metabolism

Folia Endocrinologica Japonica, 1993
Most thyroxine (T4) secreted from the thyroid is deiodinated in peripheral tissues. At least three isozymes are known in iodothyronine deiodinase which catalyzes the conversion of T4 to triiodothyronine (T3) or reverse T3. Type I 5'-deiodinase (5'D-I) exists in most tissues including the liver, kidney and thyroid.
INADA, Mitsuo, NISHIKAWA, Mitsushige
openaire   +3 more sources

Thyroid Hormone Abuse in Athletics

, 2022
Methodology and validation of LCMS thyroid hormone ...
David Handelsman (11921447)
core   +1 more source

A Novel NR3C1 Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural Modeling

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Glucocorticoid resistance syndrome (GRS) is a rare hereditary disorder caused by pathogenic variants in NR3C1, characterized by marked phenotypic heterogeneity and frequent misdiagnosis as primary aldosteronism or subclinical Cushing's syndrome.
Sufang Yun, Zhifeng Zhu, Fengye Zhou, Ying Liu, Chunfang Liang, Haitao Ju, Lin Lu, Zhaoli Yan   +7 more
wiley   +1 more source

Thyroid hormones and aging

Hormones, 2008
With an increase in age, marked changes in thyroid hormone production, metabolism, and action occur. This results in an increased prevalence of (subclinical) thyroid disease in the elderly. In general, subclinical thyroid disease is associated with an increased risk of overt thyroid dysfunction and with different negative clinical parameters.
openaire   +3 more sources

Cardioprotection and thyroid hormones

Heart Failure Reviews, 2016
The evolution of cardiac disease after an acute ischemic event depends on a complex and dynamic network of mechanisms alternating from ischemic damage due to acute coronary occlusion to reperfusion injury due to the adverse effects of coronary revascularization till post-ischemic remodeling.
Pingitore Alessandro, Nicolini Giuseppina, Kusmic Claudia, Iervasi Giorgio, Grigolini Paolo, Forini Francesca   +5 more
openaire   +2 more sources

A Novel Role for Thyroid Hormone Receptor Beta in Cellular Radiosensitivity [PDF]

, 2008
Thyroid hormone receptors (THRs) widely govern cell growth, differentiation and metabolism acting in a ligand- and cofactor-dependent manner to modulate tissue-specific gene expression. Given a large variety of genes regulated by THRs and multiplicity of
Hiroyuki NAMBA, Namba, Hiroyuki, Saenko, Vladimir, Yamashita, Shunichi, Akulevich, Natallia, Yuka NAKAZAWA, Vladimir SAENKO, Sedliarou, Ilya, Michiko MATSUSE, Rogounovitch, Tatiana, Mitsytake, Norisato, Natallia AKULEVICH, Shunichi YAMASHITA, Tatiana ROGOUNOVITCH, Nakazawa, Yuka, Matsuse, Michiko, Norisato MITSUTAKE, Ilya SEDLIAROU   +17 more
core   +1 more source