Results 161 to 170 of about 335,864 (307)

Endometrial Stromal Cell Senescence: A Non‐Negligible Factor in Recurrent Pregnancy Loss

iMetaMed, EarlyView.
As populations age, links between female reproductive aging and infertility are increasingly evident. Cellular senescence, characterized by near‐irreversible cell‐cycle arrest and accumulation of damage, can impair tissue function. In the endometrium, aberrant senescence of endometrial stromal cells (EnSCs) may compromise receptivity, hinder embryo ...
Shuang Wu, Cenlan Bu, Qinzheng Xu, Xi Cheng, Junrong Zhang, Jinling Chen, Yun‐Zhao Xu   +6 more
wiley   +1 more source

Climate factors drive the local adaptation of Old World cattle

iMeta, EarlyView.
Climate adaptation genomics of cattle. We comparatively analyzed genomic data from 85 Old World cattle breeds/populations of Eurasia and Africa to identify genetic factors associated with climate factors. Environmental genome‐wide association studies revealed 3165 single‐nucleotide polymorphisms (SNPs) with strong correlations between climate factors ...
Luyang Sun, Liangliang Jin, Ting Sun, Chenqi Bian, Fuwen Wang, Shuang Li, Hao Li, Jianyong Liu, Jicai Zhang, Johannes A. Lenstra, Artem Nedoluzhko, Zhuqing Zheng, Ruidong Xiang, Wai Yee Low, Wangdui Basang, Zhuzha Basang, Bin Li, Quji Suolang, Li Zhao, Wangmu Silang, Luobu Ciren, Zhandui Pubu, Qiangma Xire, Yanliang Song, Yuanpeng Gao, Dawei Wei, Rende Song, Min‐Sheng Peng, Bizhi Huang, Yun Ma, Xiaoting Xia, Chuzhao Lei, Ningbo Chen   +32 more
wiley   +1 more source

Novel Thyroid Hormone Receptor β Gene Variant (F245L) Causing Mild Resistance to Thyroid Hormone. [PDF]

JCEM Case Rep
Yamagami K, Kanamoto N, Yamashita Y, Sasai Y, Tagami T.   +4 more
europepmc   +1 more source

Microbial metabolites in tumor epigenetic regulation

iMeta, EarlyView.
The gut microbiome modulates tumor epigenetic regulation through bioactive metabolites derived from dietary substrates. Microbiota‐produced SCFAs, secondary BAs, one‐carbon metabolites, and tryptophan‐derived ligands regulate histone acetylation, DNA methylation, and chromatin remodeling via HDAC, DNMT, AhR, and metabolic cofactor‐dependent pathways ...
Wangzheqi Zhang, Haoling Zhang, Yan Liao, Shuya Jiang, Haolong Zhang, Chenwei Huang, Zhijing Song, Rui Zhao, Ping Lu, Xiaohong Kang, Eryan Kong, Yalin Zhu, Wei Wang, Xuesong Liu, Yisheng Chen, Zhiwen Luo, Zhaoyu Li, Di Wang, Na Xing, Yadong Guo, Jingjing Zhang, Xiaojing Wang, Wenyi Wang, Mowaffaq Adam, Bakiah Shaharuddin, Muhamad Yusri Musa, Doblin Sandai, Chenglong Zhu, Aimin Jiang, Peng Luo, Zhijie Zhao, Zui Zou   +31 more
wiley   +1 more source

Cost‐Effectiveness and Efficiency of Day Surgery Versus Elective Operations in Patients With Thyroid Neoplasms: A Multicenter Retrospective Cohort Study in China

iNew Medicine, EarlyView.
ABSTRACT Day surgery for thyroid malignancies is gaining traction globally, yet comprehensive health economic evaluations in China remain limited. This study evaluates the cost‐effectiveness and safety of thyroid day surgery versus elective inpatient operations using a large‐scale multicenter dataset.
Ying Wang, Hui Sun
wiley   +1 more source

Prognostic significance of preoperative thyroid hormone sensitivity status for recurrence in papillary thyroid carcinoma. [PDF]

Oncologist
Li C, Li S, Zhao Y, Zhang D, Fu Y, Zhou L, Li J, Li F, Du R, Liang N, Sun H.   +10 more
europepmc   +1 more source

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, EarlyView.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source

Patient‐Reported Outcomes with Selpercatinib Treatment Among Patients with RET‐Mutant Medullary Thyroid Cancer in the Phase I/II LIBRETTO‐001 Trial

The Oncologist, EarlyView., 2021
Abstract Background Medullary thyroid cancer (MTC) standard of care includes multikinase inhibitors (MKIs), which can exacerbate disease‐related diarrhea, primarily because of non‐RET kinase inhibition. We report diarrhea and other patient‐reported outcomes (PROs) with selpercatinib, a highly selective RET inhibitor, among patients with RET‐mutant MTC ...
Lori J. Wirth, Bruce Robinson, Valentina Boni, Daniel S.W. Tan, Caroline McCoach, Erminia Massarelli, Lisa M. Hess, Min‐Hua Jen, Jennifer Kherani, Elizabeth Olek, Vivek Subbiah   +10 more
wiley   +1 more source

Lymph‐based liquid biopsy: Current progress and future potential

Interdisciplinary Medicine, EarlyView.
Recent evidence under the revised Starling principle indicates that lymph‐based liquid biopsies may offer superior diagnostic performance over blood‐based counterparts in certain clinical scenarios, such as early‐stage solid tumor detection. Currently, various biomarkers within the lymphatic system show significant diagnostic potential for a range of ...
Dongdong Liu, Leheng Cheng, Xiaolin Hu, Sergio Bernardini, Hong Zhang, Ling Zhu, Yang Luo   +6 more
wiley   +1 more source

Thyroid hormone promotes fetal neurogenesis. [PDF]

JCI Insight
Salas-Lucia F, Escamilla S, Charest A, Jiang H, Stout R, Bianco AC.   +5 more
europepmc   +1 more source