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Thyroid-stimulating hormone, thyroid hormones, and bone loss

Current Osteoporosis Reports, 2009
It has become accepted by virtue of rich anecdotal experience and clinical research that thyrotoxicosis is associated with high-turnover osteoporosis. The bone loss, primarily due to accelerated resorption that is not compensated by a coupled increase in bone formation, has been attributed solely to elevated thyroid hormone levels.
Mone, Zaidi   +7 more
openaire   +2 more sources

Thyroid Hormone and Cardioprotection

Comprehensive Physiology, 2016
ABSTRACT The heart is a major target of thyroid hormones, with maintenance of euthyroid hormone balance critical for proper function. In particular, chronic low thyroid function can eventually lead to dilated heart failure with impaired coronary blood flow.
Anthony Martin, Gerdes, Kaie, Ojamaa
openaire   +2 more sources

Thyroid hormone resistance

Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 2006
Resistance to thyroid hormone (RTH) is a rare autosomal dominant inherited syndrome of reduced end-organ responsiveness to thyroid hormone. Patients with RTH have elevated serum free thyroxine (FT4) and free triiodothyronine (FT3) concentrations and normal or slightly elevated serum thyroid stimulating hormone (TSH) level.
Tolulope O, Olateju   +1 more
openaire   +2 more sources

Novel thyroid hormones

Endocrine, 2019
The field of thyroid hormone signaling has grown more complex in recent years. In particular, it has been suggested that some thyroid hormone derivatives, tentatively named "novel thyroid hormones" or "active thyroid hormone metabolites", may act as independent chemical messengers.
Zucchi R., Rutigliano G., Saponaro F.
openaire   +3 more sources

Resistance to Thyroid Hormone

Hormone Research, 2009
Resistance to thyroid hormone (RTH) is usually dominantly inherited and is characterized by elevated free thyroid hormones in the serum and failure to suppress pituitary thyroid stimulating hormone (TSH) secretion with variable refractoriness to hormone action in peripheral tissues.
openaire   +2 more sources

Thyroid hormone resistance

Postgraduate Medical Journal, 2008
Abstract Thyroid hormone resistance (THR) is a rare syndrome of reduced end organ sensitivity. Patients with THR have elevated serum free thyroxine (FT4), free triiodothyronine (FT3), but normal or slightly elevated serum thyrotropin values.
N K, Agrawal   +4 more
openaire   +2 more sources

Thyroid Hormone Deiodination

Thyroid, 1990
A case is presented of Graves' disease occurring in a patient with hemiagenesis of the thyroid gland. The diagnosis was suspected clinically and was confirmed by laboratory tests and imaging studies, as well as by the presence of thyroid-stimulating antibody.
openaire   +2 more sources

Thyroid Hormones and Derivatives: Endogenous Thyroid Hormones and Their Targets

2018
More than a century after the discovery of L-Thyroxine, the main thyroid hormone secreted solely by the thyroid gland, several metabolites of this iodinated, tyrosine-derived ancestral hormone have been identified. These are utilized as hormones during development, differentiation, metamorphosis, and regulation of most biochemical reactions in ...
openaire   +2 more sources

Metabolism of the Thyroid Hormones

Hormone Research, 2008
This review covers the current knowledge about the various metabolic pathways involved in the conversion of thyroid hormones to the thyromimetically active and inactive iodothyronines. The concerted mechanism of systemic and local production of iodothyronines by tissue-specific iodothyronine deiodinase isozymes will ultimately determine the expression ...
J, Köhrle, G, Brabant, R D, Hesch
openaire   +2 more sources

Thyroid hormones and the heart

Hormone Molecular Biology and Clinical Investigation, 2014
Abstract Thyroid hormones have a significant impact on heart function, mediated by genomic and non-genomic effects. Consequently, thyroid hormones deficit as well as excess are expected to result in profound changes in cardiac function regulation and cardiovascular hemodynamics.
Hernando, Vargas-Uricoechea   +1 more
openaire   +2 more sources

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