Results 1 to 10 of about 467,905 (403)
Lack of thyroid hormone receptor beta is not detrimental for non-alcoholic steatohepatitis progression [PDF]
iScience, 2023 Summary: Agonists for thyroid hormone receptor β (TRβ) show promise in preclinical studies and clinical trials to improve non-alcoholic fatty liver disease.
Nuria Lopez-Alcantara +4 more
doaj +2 more sources
Selective thyroid hormone receptor modulators
Indian Journal of Endocrinology and Metabolism, 2013 Thyroid hormone (TH) is known to have many beneficial effects on vital organs, but its extrapolation to be used therapeutically has been restricted by the fact that it does have concurrent adverse effects.
Girish Raparti +6 more
doaj +3 more sources
Ecotoxicology and Environmental Safety, 2022 Cadmium is a ubiquitous environmental pollutant, which can increase the risk of preeclampsia. This study was designed to determine the mechanism of cadmium exposure during pregnancy impaired placental angiogenesis that was associated with the occurrence ...
Xuan Li +10 more
doaj +1 more source
Crosstalk between integrin αvβ3 and estrogen receptor-α is involved in thyroid hormone-induced proliferation in human lung carcinoma cells. [PDF]
PLoS ONE, 2011 A cell surface receptor for thyroid hormone that activates extracellular regulated kinase (ERK) 1/2 has been identified on integrin αvβ3. We have examined the actions of thyroid hormone initiated at the integrin on human NCI-H522 non-small cell lung ...
Ran Meng +10 more
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Main Factors Involved in Thyroid Hormone Action
Molecules, 2021 The thyroid hormone receptors are the mediators of a multitude of actions by the thyroid hormones in cells. Most thyroid hormone activities require interaction with nuclear receptors to bind DNA and regulate the expression of target genes. In addition to
Lorena Tedeschi +3 more
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Graves’ disease coexisted with resistance to thyroid hormone: a case report
Journal of Medical Case Reports, 2021 Background Resistance to thyroid hormone is a rare autosomal dominant disorder characterized by reduced responsiveness to thyroid hormone and can cause syndrome of inappropriate secretion of thyroid stimulating hormone.
Hiroshi Akahori, Rika Usuda
doaj +1 more source
Receptor modulators associated with the hypothalamus -pituitary-thyroid axis
Frontiers in Pharmacology, 2023 The hypothalamus-pituitary-thyroid (HPT) axis maintains normal metabolic balance and homeostasis in the human body through positive and negative feedback regulation.
Xianbin Cheng +7 more
doaj +1 more source
Hormone Selectivity in Thyroid Hormone Receptors [PDF]
Molecular Endocrinology, 2001 Separate genes encode thyroid hormone receptor subtypes TRalpha (NR1A1) and TRbeta (NR1A2). Products from each of these contribute to hormone action, but the subtypes differ in tissue distribution and physiological response. Compounds that discriminate between these subtypes in vivo may be useful in treating important medical problems such as obesity ...
R L, Wagner +9 more
openaire +2 more sources
Clinical Case Reports, 2021 The same thyroid hormone receptor B gene (THRB) mutation led to thyroid hormone resistance with different clinical manifestations in the kindreds.
Bingkun Huang +7 more
doaj +1 more source
Toxics, 2023 In the present study, the developmental toxicity and endocrine-disrupting effects of fenpropathrin on Gobiocypris rarus during the early life stage were studied using a semi-static water exposure method.
Lei Wang +6 more
doaj +1 more source