Results 121 to 130 of about 1,772,358 (255)
The Anatomical Record, EarlyView.This review redefines the carotid bulb (CB) as a variable geometric dilation shaped by hemodynamics and the carotid sinus (CS) as a conserved neurohistological baroreceptor field. Distinguishing these entities clarifies a century of anatomical confusion and links geometry, neurohistology, and clinical interpretation within a unified framework ...
Răzvan Costin Tudose +2 more
wiley +1 more source
Arthritis &Rheumatology, EarlyView.Objective To assess the association between duration of targeted therapy exposure and cancer risk in patients with spondyloarthritis (SpA), including those with psoriatic arthritis, axial SpA, and other subtypes. Methods This nationwide cohort study used the French health insurance database to identify adults with SpA initiating a targeted therapy ...
Karine Tankovic +7 more
wiley +1 more source
Фактори експериментальної еволюції організмів, 2015 Aims. The human DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) protects cells against mutations and cell death. On the other hand, it causes the resistance of cancer cells to alkylating chemotherapy.
З. М. Нідоєва +4 more
doaj
Thyroid hormone receptor and thyroid hormone refractory disease.
Nihon Naika Gakkai Zasshi, 1999 転写制御の分子メカニズムに関する研究が,ここ数年顕著に進展している.転写制御に重要な働きを持つ転写共役因子がいくつか同定され,転写促進および抑制機構,転写制御とクロマチンの構造変化の関連などが解明され始めた.転写調節因子としての核内受容体を見たとき,甲状線ホルモン受容体(TR)はレチノイン酸受容体とともにもっとも典型的な転写因子型受容体であり,その作用機構は多くのbig labによって精力的に研究されている.一方,甲状腺ホルモン不応症から見出されるTR異常は, TRの機能と構造に重要な情報を提供してきた.疾患モデルとして,トランスジェニックマウスやノックアウトマウスの作成と解析も行われている.
openaire +2 more sources
Genetic and population analyses implicate thyroid‐related regulation of RNF144B in chondrocalcinosis
Arthritis &Rheumatology, Accepted Article.Objectives Chondrocalcinosis, characterized by calcium crystal deposition within articular cartilage, affects 5–15% of the general population and has recently been identified as an osteoarthritis risk factor. However, Its biological pathways remain unclear.
Yahong Wu +15 more
wiley +1 more source
Autism Research, EarlyView.ABSTRACT Exogenous prenatal exposures may affect neurodevelopment across multiple generations. We investigated grandmother and grandfather smoking, alcohol, coffee, and tea consumption during pregnancy in relation to their grandchildren's risk of autism spectrum disorder (ASD).
Michelle Pearl +6 more
wiley +1 more source
Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics
British Journal of Clinical Pharmacology, EarlyView.Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay +5 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims This work aimed to contextualize glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and glucose‐dependent insulinotropic polypeptide (GIP) receptor agonists safety and efficacy regarding weight management (WM); we analysed Food and Drug Administration (FDA) Medical Reviews to analyse 14 medications using patient‐exposure year normalization and ...
Aishwarya Prasad +4 more
wiley +1 more source
Modified Chromenes as Precursors to TAAR Regulators [PDF]
, 2011 200 million people worldwide are living with a thyroid disorder related to a hormonal imbalance. Symptoms of this imbalance include deviations from normal heart rates and metabolic rates.
Lehmann, Jonathan, Hart, Matthew
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British Journal of Clinical Pharmacology, EarlyView.Aims CYP2C19 is one of the most important pharmacogenes, and its activity is highly variable due to factors such as genetics or drug–drug interactions. Due to the lack of an appropriate endogenous CYP2C19 biomarker, surrogate methods to assess its activity are warranted.
Julian Peter Müller +9 more
wiley +1 more source