Bilateral Ophthalmoplegia After Neoadjuvant Pembrolizumab for Oral Cavity Squamous Cell Carcinoma
The Laryngoscope, EarlyView.The role of immune checkpoint inhibition (ICI) therapy in the treatment of head and neck squamous cell carcinoma (HNSCC) is expanding with increased utilization of neoadjuvant and adjuvant pembrolizumab in the setting of locally advanced disease. This report describes the presentation and management of the first known case of pembrolizumab‐induced ...
Leonard E. Estephan +3 more
wiley +1 more source
Ageing-Dependent Thyroid Hormone Receptor α Reduction Activates IP3R1-Meditated Ca<sup>2+</sup> Transfer in MAM and Exacerbates Skeletal Muscle Atrophy in Mice. [PDF]
Cell ProlifShi R +7 more
europepmc +1 more source
Genetic Mutations in Recurrent/Metastatic Papillary Thyroid Carcinoma
The Laryngoscope, EarlyView.We investigated the mutational landscape and prognostic implications of recurrent/metastatic papillary thyroid carcinoma using nationwide C‐CAT data from 348 patients. CDKN2A, KMT2D, and concurrent TERT/BRAF mutations were independently associated with poorer overall survival, highlighting the potential prognostic value of comprehensive genomic ...
Hiromi Nagano +3 more
wiley +1 more source
Thyroid hormone receptor subtype-specific function in controlling organ-specific developmental timing and rate during <i>Xenopus</i> development. [PDF]
Front Endocrinol (Lausanne)Tanizaki Y, Shi YB.
europepmc +1 more source
Radiofrequency Ablation as a Safe and Effective Treatment for Thyroid Nodules After Lobectomy
The Laryngoscope, EarlyView.ABSTRACT Background A new symptomatic nodule may develop or a preexisting nodule may grow to warrant treatment in the remaining lobe of patients who previously had a unilateral thyroid lobectomy. Conventional management often results in completion thyroidectomy, but radiofrequency ablation (RFA) offers a minimally invasive alternative to surgical ...
Yaser Bashumeel +11 more
wiley +1 more source
A multipart phase 1 study of the safety, pharmacodynamics and pharmacokinetics of ALG-055009, a novel thyroid hormone receptor beta (THR-β) agonist for metabolic dysfunction-associated steatohepatitis (MASH), in healthy participants. [PDF]
Clin Pharmacol Drug DevCharfi H +11 more
europepmc +1 more source
Visual Parathyroid Identification in Thyroidectomy: A Decision Curve Analysis of Gland Preservation
The Laryngoscope, EarlyView.Intraoperative visual identification remains the standard approach to parathyroid preservation during thyroidectomy, yet its accuracy has rarely been quantified against an objective reference. Among 50 suspected parathyroid specimens verified by fine‐needle aspiration PTH washout, expert consensus visual identification achieved 84.0% sensitivity but ...
Paveena Pithuksurachai +5 more
wiley +1 more source
Thyroid hormone receptor interacting protein 13 is associated with prognosis and immunotherapy efficacy in human cancers: a pan-cancer analysis. [PDF]
Discov OncolZheng S, Wang H, Wang Y.
europepmc +1 more source
Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research
Mass Spectrometry Reviews, EarlyView.Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik +3 more
wiley +1 more source
Thyroid hormone receptor- and stage-dependent transcriptome changes affect the initial period of Xenopus tropicalis tail regeneration. [PDF]
BMC GenomicsWang S +5 more
europepmc +1 more source