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Thyroid Hormone Receptors and Responses
1979Publisher Summary This chapter discusses the responses of thyroid hormone receptors. The thyroid hormone receptor is unique in that it is an intrinsic chromosomal nonhistone protein known to be involved in the regulation of the expression of specific genes. These receptors are bound to chromatin in the absence or the presence of thyroid hormone. They
J D, Baxter +11 more
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2010
Thyroid hormone promotes a diverse range of developmental, neurological and metabolic functions in vertebrate species. Human thyroid disorders result in a correspondingly wide range of disease symptoms. The functions of thyroid hormone are mediated by a small group of thyroid hormone receptors encoded by two conserved genes.
BjÖRn VennstrÖM +2 more
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Thyroid hormone promotes a diverse range of developmental, neurological and metabolic functions in vertebrate species. Human thyroid disorders result in a correspondingly wide range of disease symptoms. The functions of thyroid hormone are mediated by a small group of thyroid hormone receptors encoded by two conserved genes.
BjÖRn VennstrÖM +2 more
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Resistance to thyroid hormone mediated by defective thyroid hormone receptor alpha
Biochimica Et Biophysica Acta - General Subjects, 2013Thyroid hormone acts via receptor subtypes (TRα1, TRβ1, TRβ2) with differing tissue distributions, encoded by distinct genes (THRA, THRB). THRB mutations cause a disorder with central (hypothalamic-pituitary) resistance to thyroid hormone action with markedly elevated thyroid hormone and normal TSH levels.This review describes the clinical features ...
Mark Gurnell +2 more
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The Thyroid Hormone Receptors: Molecular Basis of Thyroid Hormone Resistance
Hormone Research, 1992Major progress has been achieved in the mechanism of action of thyroid hormones thanks to the identification of the T3 receptor as the product of the proto-oncogene c-erbA. Recognition of subsets of receptors with and without T3-binding properties and of the interaction of different receptors with each other leads to new insights in cell regulation and
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1995
Thyroid hormones notably Triiodothyronine (T3) and thyroxine (T4) play important roles in many biological processes in all vertebrates (De Groot et al, 1984). They affect growth, development and differentiation, metabolism and homeostasis. A particularly striking observation was made by Gudernatsch in the early part of this century that thyroid ...
F. Javier Piedrafita, Magnus Pfahl
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Thyroid hormones notably Triiodothyronine (T3) and thyroxine (T4) play important roles in many biological processes in all vertebrates (De Groot et al, 1984). They affect growth, development and differentiation, metabolism and homeostasis. A particularly striking observation was made by Gudernatsch in the early part of this century that thyroid ...
F. Javier Piedrafita, Magnus Pfahl
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Comprehensive Physiology, 1998
Abstract The sections in this article are: 3,5,3′ Triiodo‐ L ‐Thyronine (T 3 ) Receptors: Overview
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Abstract The sections in this article are: 3,5,3′ Triiodo‐ L ‐Thyronine (T 3 ) Receptors: Overview
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Promotion by thyroid hormone of cytoplasm-to-nucleus shuttling of thyroid hormone receptors
Steroids, 2008Confocal microscopy and cell fractionation studies have revealed the residence of nuclear thyroid hormone receptors (TR) in cytoplasm. Treatment of cells with the hormone (L-thyroxine or 3,5,3'-triiodo-L-thyronine, T(3)) results in shuttling of TR into the nuclear compartment. Confocal microscopy has also disclosed that TR in the nuclear compartment is
Paul J, Davis +2 more
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Resistance to Thyroid Hormone in a Patient Without Thyroid Hormone Receptor Mutations
Thyroid, 2002Resistance to thyroid hormone (RTH) is a clinical syndrome characterized by elevated serum thyroid hormone (TH) levels, unsuppressed thyrotropin (TSH) levels, and tissue hyposensitivity to TH. In almost all cases, the genetic basis of RTH lies in mutation of one of the two TH receptor beta (TRbeta) alleles. Recently, patients from several families with
S, Parikh +5 more
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Nuclear thyroid hormone receptors: ontogeny and thyroid hormone effects in sheep
American Journal of Physiology-Endocrinology and Metabolism, 1989To investigate the mechanism(s) responsible for the paucity of fetal thyroid hormone effects, thyroid hormone nuclear receptor (T3NR) binding characteristics were quantified in liver and brain of fetal and neonatal sheep. Maximal binding capacities [MBC; mean +/- SE fmol 3,5,3'-triiodothyronine (T3)/mg DNA] in liver increased from values of 68 +/- 14 ...
D, Polk +3 more
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Mild resistance to thyroid hormone with a truncated thyroid hormone receptor ß
Experimental and Clinical Endocrinology & Diabetes, 2009Recent studies have revealed mutations in the thyroid hormone receptor beta (TR beta) gene as a cause of the most cases of the thyroid hormone resistance syndrome. We have identified a novel nonsense mutation in codon 449 in the 3' end of exon 10 in the TR beta gene in a 16-year-old male patient with generalized resistance to thyroid hormone who also ...
M, Taniyama +8 more
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