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American Journal of Physiology-Endocrinology and Metabolism, 2003
Isoforms of the thyroid hormone receptor ( TR) α and TRβ genes mediate thyroid hormone action. How TR isoforms modulate tissue-specific thyroid hormone (TH) action remains largely unknown. The steroid receptor coactivator-1 (SRC-1) is among a group of transcriptional coactivator proteins that bind to TRs, along with other members of the nuclear ...
Sadow, P.M. +6 more
openaire +3 more sources
Isoforms of the thyroid hormone receptor ( TR) α and TRβ genes mediate thyroid hormone action. How TR isoforms modulate tissue-specific thyroid hormone (TH) action remains largely unknown. The steroid receptor coactivator-1 (SRC-1) is among a group of transcriptional coactivator proteins that bind to TRs, along with other members of the nuclear ...
Sadow, P.M. +6 more
openaire +3 more sources
Thyroid hormone receptor mutations and disease: beyond thyroid hormone resistance
Trends in Endocrinology & Metabolism, 2005Thyroid hormone receptors (TRs) are ligand-dependent transcription factors that mediate the biological activities of thyroid hormone (T3). Two THR genes (A and B), located on different chromosomes, yield four T3-binding isoforms with highly conserved sequences in the DNA- and ligand-binding domains.
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Thyroid Hormone Receptor α1 Mutants Impair B Lymphocyte Development in a Mouse Model
Thyroid, 2021Sheue-Yann Cheng, Sunmi Park
exaly