Results 261 to 270 of about 1,914,121 (297)

Resistance to thyroid hormone mediated by defective thyroid hormone receptor alpha

Biochimica et Biophysica Acta (BBA) - General Subjects, 2013
Thyroid hormone acts via receptor subtypes (TRα1, TRβ1, TRβ2) with differing tissue distributions, encoded by distinct genes (THRA, THRB). THRB mutations cause a disorder with central (hypothalamic-pituitary) resistance to thyroid hormone action with markedly elevated thyroid hormone and normal TSH levels.This review describes the clinical features ...
Schoenmakers, N, Moran, C, Peeters, Robin, Visser, Theo, Gurnell, M, Chatterjee, K   +5 more
openaire   +2 more sources

Specificity of thyroid hormone receptor subtype and steroid receptor coactivator-1 on thyroid hormone action

American Journal of Physiology-Endocrinology and Metabolism, 2003
Isoforms of the thyroid hormone receptor ( TR) α and TRβ genes mediate thyroid hormone action. How TR isoforms modulate tissue-specific thyroid hormone (TH) action remains largely unknown. The steroid receptor coactivator-1 (SRC-1) is among a group of transcriptional coactivator proteins that bind to TRs, along with other members of the nuclear ...
Sadow, P.M., Chassande, Olivier, Gauthier, K., Samarut, Jacques, Xu, J., O'Malley, B.W., Weiss, R.E.   +6 more
openaire   +3 more sources

Thyroid hormone receptor mutations and disease: beyond thyroid hormone resistance

Trends in Endocrinology & Metabolism, 2005
Thyroid hormone receptors (TRs) are ligand-dependent transcription factors that mediate the biological activities of thyroid hormone (T3). Two THR genes (A and B), located on different chromosomes, yield four T3-binding isoforms with highly conserved sequences in the DNA- and ligand-binding domains.
openaire   +2 more sources

Systemic Therapy for Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Negative Early Stage and Metastatic Breast Cancer

Ca-A Cancer Journal for Clinicians, 2023
Hope Rugo, Özge Gümüşay, Laura A Huppert   +2 more
exaly  

Thyroid Hormone Receptors

2001
Dressel, U., Baniahmad, A.
openaire   +2 more sources

Thyroid Hormone Receptors

2021
Maria Laura Tanda, Silvia Ippolito
openaire   +1 more source

THYROID HORMONE RECEPTOR AGONISTS

2021
DAI XING, WANG YAOLIN, JIANG YUEHENG, LIU YANQIN, HAN ZIXING, WANG ZHENWU, TAO LIANGSHAN, SHI ZHE   +7 more
openaire   +2 more sources

The Thyroid Hormone Receptor Resource

Thyroid, 1997
openaire   +2 more sources

New Developments in the Diagnosis and Treatment of Thyroid Cancer

Ca-A Cancer Journal for Clinicians, 2013
David F Schneider, Herbert Chen
exaly  

Thyroid Hormone Receptors

2004
openaire   +2 more sources