Advanced Science, EarlyView.This study demonstrates that bisphenol analogues, particularly BPAF, bind to progesterone receptor, promoting breast cancer cell proliferation, migration, and mammary tumor growth, indicating that bisphenol A substitutes may pose equal or greater health risks.
Xiaotong Ji +8 more
wiley +1 more source
Journal of Pediatric Surgery Case Reports, 2018 We report here a male case of autonomous adenoma (AA) in the thyroid that was caused by a somatic heterozygous mutation in the thyroid-stimulating hormone receptor (TSHR) gene at codon 453, which encodes the second transmembrane domain of the protein ...
Kotaro Tomonaga +11 more
doaj +1 more source
Physiopathological Implications of 7TM Receptors [PDF]
, 2010 Seven-transmembrane (7TM) receptors are one of the most important proteins involved in perception of extracellular stimuli and regulation of variety of intracellular signaling pathways.
Cygankiewicz, Adam
core +1 more source
TSHR‐Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition
Advanced Science, EarlyView.This study presents YC3, a novel inhibitory TSHR‐targeting aptamer, as a promising therapeutic for Graves' ophthalmopathy (GO). YC3 suppresses pathological phenotypes in human orbital fibroblasts and improves outcomes in GO mice by binding to a previously unidentified allosteric site on TSHR, demonstrating the potential of aptamers in advancing ...
Yanchen Zhang +16 more
wiley +1 more source
European multicentre study on outcome of surgery for sporadic primary hyperparathyroidism
BJS (British Journal of Surgery), EarlyView., 2020 Some 5861 patients undergoing first‐time surgery for sporadic primary hyperparathyroidism were registered in the Eurocrine® database between 2015 and 2018. The use of intraoperative parathyroid hormone measurement decreased the risk of conversion and persistent hypercalcaemia.
A. Bergenfelz +3 more
wiley +1 more source
Analysis of structure-activity and structure-mechanism relationships among thyroid stimulating hormone receptor binding chemicals by leveraging ToxCast library [PDF]
, 2023 Ajaya Kumar Sahoo +4 more
openalex +1 more source
Not all elevated hormones are toxic: A case of thyroid hormone resistance
Journal of Family Medicine and Primary Care, 2016 Resistance to thyroid hormone syndrome (RTH) is a rare disorder and is usually inherited as dominantly negative autosomal trait. RTH is caused by mutations in the thyroid hormone receptor beta.
Rajeev Philip +3 more
doaj +1 more source
The prognostic value of thyroid-stimulating immunoglobulin in the management of Graves’ disease
Therapeutic Advances in Endocrinology and Metabolism, 2021 Background: The bioassay of thyroid-stimulating immunoglobulin was reported to have a similar performance to the commonly used thyroid-stimulating hormone binding inhibition assay, also known as thyroid receptor antibody assay. The normal reference range
Yulin Zhou +5 more
doaj +1 more source
Relations of environmental contaminants, algal toxins, and diet with the reproductive success of American alligators on Florida Lakes [PDF]
, 2001 (113 page ...
Arnold, Beverly S. +3 more
core
Impact of contraception and IVF hormones on metabolic, endocrine, and inflammatory status [PDF]
, 2020 Assisted reproductive technologies (ART) represent commonly utilized management strategies for infertility with multifactorial causes (including genetically predisposed diseases). Amongst ART, in vitro fertilization (IVF) is the most popular.
Barber, Thomas M. +2 more
core +1 more source