Results 81 to 90 of about 1,914,121 (297)

Thyroid hormone resistance beta and autoimmune thyroid disease - a family case study highlighting diagnostic and therapeutic challenges

Cardiovascular Diabetology. Endocrinology Reports
Background Resistance to thyroid hormone (RTH) is a rare endocrine disorder, most commonly caused by mutations in the thyroid hormone receptor β (TRβ) gene, resulting in the RTH beta (RTHβ) subtype.
Mirjana Đukić, Zlata Kovačević, Karin Zibar Tomšić, Emir Muzurović   +3 more
doaj   +1 more source

Not all elevated hormones are toxic: A case of thyroid hormone resistance

Journal of Family Medicine and Primary Care, 2016
Resistance to thyroid hormone syndrome (RTH) is a rare disorder and is usually inherited as dominantly negative autosomal trait. RTH is caused by mutations in the thyroid hormone receptor beta.
Rajeev Philip, Mohan Krishnakumar Padikal, Altaf Alinausad, Charamelsankaran Keshavan   +3 more
doaj   +1 more source

TH/TRs–COL11A2 Axis Mediates Loss of a Differentiated Astrocyte State in Hypogyrified Brains

Advanced Science, EarlyView.
Using a gyrencephalic congenital hypothyroidism pig model, this study reveals cerebral atrophy and cortical hypogyrification. Single‐cell sequencing identifies astrocytes as major TH‐responsive cells, with the COL11A2‐enriched Astro‐2 state nearly absent.
Ying Zhang, Xiao Wang, Hongyan Ma, Pengcheng Lyu, Shuangjie Tian, Ruojun Zong, Jiani Chen, Gang Ren, Yongjiang Yang, Zichen Yang, Guosong Qin, Naishi Li, Yanfang Wang, Jianwei Jiao, Jianguo Zhao   +14 more
wiley   +1 more source

EXPRESSION OF GENES OF IODOTHYRONINE DEIODINASES TYPES 1, 2 AND 3, IODOTYROSINE DEIODINASE, THYROID HORMONE RECEPTOR ALPHA AND BETA AND ACETYLTRANSFERASES TYPES 1 AND 2 IN PATIENTS WITH EUTHYROID AND TOXIC GOITER IN THE IRKUTSK REGION

Байкальский медицинский журнал
Background. Thyroid gland pathology is the leading endocrine disease. According to modern requirements of a personalized approach to medicine, there is a need to study the expression of genes involved in immunoregulation and biosynthesis of thyroid ...
Elena A. Ilyicheva, Lyubov V. Rodionova, Liliya G. Samoilova, Tatiana A. Roy, Gleb A. Bersenev   +4 more
doaj   +1 more source

ERα–PADI4–CXCL8 Axis Drives MDSC‐Mediated Immune Evasion in Anaplastic Thyroid Carcinoma

Advanced Science, EarlyView.
MAPK‐driven ligand‐independent ERα activation drives PADI4 transcription and translation. This enzyme then modifies CXCL8 chemokines through citrullination, generating a potent chemoattractant gradient specifically for myeloid‐derived suppressor cells.
Dongdong Zhang, Ying Cai, Junbin Zhang, Jianyong Zhang, Ran Jing, Ming Cai   +5 more
wiley   +1 more source

DNA binding of thyroid hormone receptor.

, 1994
Thyroid hormone receptors are essential to the control of gene expression by thyroid hormone. These transcription factors are part of a family which includes receptors for steroid hormones, retinoic acids and vitamin D$\sb3.$ In order to understand the ...
Katz, Ronald William
core   +4 more sources

Liquid crystal monomers disrupt photoreceptor patterning of zebrafish larvae via thyroid hormone signaling

Environment International
Liquid crystal monomers (LCMs) are the raw material for liquid crystal displays, and their use is steadily increasing in electronic products. Recently, LCMs have been reported to be novel endocrine disrupting chemicals, however, the mechanisms underlying
Shan He, Jia He, Siying Ma, Kunyu Wei, Fengchang Wu, Jian Xu, Xiaowei Jin, Yuanhui Zhao, Christopher J. Martyniuk   +8 more
doaj   +1 more source

Coexistence of resistance to thyroid hormone and ectopic thyroid: ten-year follow-up

Archives of Endocrinology and Metabolism, 2016
SUMMARY Resistance to thyroid hormone (RTH) coexisting with ectopic thyroid is rare. Here we report a case of RTH with ectopic thyroid. A ten-year-old girl had been misdiagnosed as congenital hypothyroidism and treated with levothyroxine since she was ...
Man-Li Guo, Xiao Zheng, Liu-Xue Yang, Ya-Li Qiu, Liang Cheng, Shao-Gang Ma   +5 more
doaj   +1 more source

A thyroid hormone receptor-dependent glucocorticoid induction. [PDF]

, 1994
peer reviewedGlucocorticoid and thyroid hormones exert their effects in many body tissues by binding to their respective receptors. The search for possible cross-talking mechanisms in overlapping target cells led to the discovery of synergism between a ...
Steiner, Christoff, Leers, Joerg, Renkawitz, Rainer, Muller, Marc   +3 more
core   +1 more source

NCOA4 Accelerates Abdominal Aortic Aneurysm Formation by Regulating Macrophage Activation and Ferroptosis via STAT1–CH25H Axis

Advanced Science, EarlyView.
Under pathological stimulation, NCOA4 in macrophages interacts with STAT1 to promote CH25H transcription. The subsequent increase in 25‐HC production activates macrophages, triggers inflammatory responses and ferroptosis, and accelerates the progression of AAA.
Zhinan Wu, Yuxuan Qian, Wenyi Xu, Fei Liao, Xueliang Liu, Xiao Kuang, Guqing Luo, Xinjie He, Lixian Jiang, Song Ding   +9 more
wiley   +1 more source