Results 61 to 70 of about 1,772,358 (255)
GAD65 Antibody ELISA With Extended Reportable Range: Validation and Guidance for Neurological Practice
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective
To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.Andrew McKeon, Dana Olofson, Diana Anissian, Divyanshu Dubey, Eoin P. Flanagan, Max C. Herman, Sarosh R. Irani, Daniel H. Lachance, Maria A. Willrich, Sean Pittock, John R. Mills, Anastasia Zekeridou +11 morewiley +1 more sourceActions of Thyroid Hormone Analogues on Chemokines
Journal of Immunology Research, 2016 The extracellular domain of plasma membrane integrin αvβ3 contains a receptor for thyroid hormone (L-thyroxine, T4; 3,5,3′-triiodo-L-thyronine, T3); this receptor also binds tetraiodothyroacetic acid (tetrac), a derivative of T4.Paul J. Davis, Gennadi V. Glinsky, Hung-Yun Lin, Shaker A. Mousa +3 moredoaj +1 more sourceHyperthyroidism due to struma ovarii: Diagnostic pitfalls and preventing thyroid storm
Gynecology and Minimally Invasive Therapy, 2017 We report struma ovarii in a case that had hyperthyroidism and was treated with laparoscopic tumor resection. A 40-year-old Japanese woman presented with tachycardia, finger tremor, and weight loss. Although blood examination showed hyperthyroidism, test Koichi Nagai, Hiroshi Yoshida, Kayo Katayama, Yumi Ishidera, Yuka Oi, Noriko Ando, Hiroyuki Shigeta +6 moredoaj +1 more sourceEffects of Thyroxine Exposure on Osteogenesis in Mouse Calvarial Pre-Osteoblasts [PDF]
, 2013 The incidence of craniosynostosis is one in every 1,800-2500 births. The gene-environment model proposes that if a genetic predisposition is coupled with environmental exposures, the effects can be multiplicative resulting in severely abnormal phenotypes.Mohammed Elsalanty, Jack C Yu, Cray, JJ, Elsalanty, M, Yu Jack C., James J Cray, Weinberg, SM, Khaksarfard Kameron, Cray, James J., Yu, JC, Khaksarfard, K, Yu, Jack C., Elsalanty, Mohammed, Kameron Khaksarfard, Weinberg Seth M., Weinberg, Seth M., Cray James J., Khaksarfard, Kameron, Seth M Weinberg, Elsalanty Mohammed +19 morecore +2 more sourcesThe Lupus Damage Index Revision Program: Results From the Item Generation and Reduction Phases
Arthritis Care &Research, EarlyView.Objective
A data‐driven and expert/patient consensus‐based project to develop a revised Systemic Lupus International Collaborating Clinics (SLICC)/American College of Rheumatology (ACR) Damage Index (SDI) is under way supported by SLICC, ACR, and the Lupus Foundation of America. Our objective is to report the item generation and reduction phase results Burak Kundakci, Megan R. W. Barber, Ann E. Clarke, Sindhu R. Johnson, Anselm Mak, Hermine I. Brunner, Murat Inanc, Rosalind Ramsey‐Goldman, Guillermo Ruiz‐Irastorza, Ellen M. Ginzler, John G. Hanly, Alexandra Legge, Cynthia Aranow, Laurent Arnaud, Nathalie Costedoat‐Chalumeau, Dafna D. Gladman, Søren Jacobsen, Michelle Petri, Clovis A. Silva, Évelyne Vinet, Alexandre E. Voskuyl, SDI Revision Literature Review Groups, SDI Revision Delphi Panel, SDI Revision Item Reduction Committee, SDI Revision Clinical Domain Groups, Ian N. Bruce +25 morewiley +1 more sourceA Role for Thyroid Hormone Transporters in Transcriptional Regulation by Thyroid Hormone Receptors [PDF]
Molecular Endocrinology, 2003 Thyroid hormones (THs) must be taken up by target cells to act at the genomic level through binding to nuclear thyroid hormone receptors (TRs). Extensive study has been made of mechanisms by which TH-bound TRs regulate transcription, yet little is known about the critical upstream step, i.e. how THs enter the cell.Ritchie, J. W. A., Shi, Y. -B., Hayashi, Y., Baird, F. E., Muchekehu, R. W., Christie, G. R., Taylor, P. M. +6 moreopenaire +3 more sourcesA case of congenital autonomous thyroid adenoma with a somatic activating gene mutation in the thyroid-stimulating hormone receptor
Journal of Pediatric Surgery Case Reports, 2018 We report here a male case of autonomous adenoma (AA) in the thyroid that was caused by a somatic heterozygous mutation in the thyroid-stimulating hormone receptor (TSHR) gene at codon 453, which encodes the second transmembrane domain of the protein ...Kotaro Tomonaga, Kazunori Tahara, Toshihiko Watanabe, Michinobu Ohno, Katsuhiro Ogawa, Mai Kutsukake, Akihiro Fujino, Tomoro Hishiki, Kenichi Kinjyo, Reiko Horikawa, Noriyuki Katsumata, Yutaka Kanamori +11 moredoaj +1 more sourceA Genome-Wide Association Meta-Analysis of Circulating Sex Hormone-Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation [PDF]
, 2012 Sex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and biologic availability of sex steroid hormones, primarily testosterone and estradiol.Frank H de Jong, Lyytikäinen LP, Vasan, Ramachandran S, Wichmann HE, Mei, Yong, Dhananjay Vaidya, Prescott, Jennifer, Douglas P. Kiel (150100), Shalender Bhasin (112670), Papunen, Laure Morin, Murray, A, McCarthy, Mark I, Stephen J. Chanock (14311), Anneli Pouta, Fornage, Myriam, van der Schouw, Y.T., Lehtimäki Terho, Biffar Reiner, Mangino, M., Schwartz SM, Bandinelli, S, Mellström, D, Rexrode, Kathryn, Ruokonen, A., Cummings S, Stolk Lisette, Stephen M Schwartz, David Karasik, Martikainen Hannu, Miljkovic, I, Mangino Massimo, Coviello, A.D., Reiner, A.P., Cox, DG, Daniel Mirel (150151), Murabito Joanne M., Murabito JM, Uitterlinden, André G, Perry, J.R., Keildson, S., Hunter David J., Ouyang, Pamela, Järvelin, MR, van Gils, van, Marcello Maggio, Ljunggren, O. (Östen), Frayling, Timothy M., Marc J Gunter, John-Olov Jansson, Hofman, A., Koster, A, Harris, T.B. (Tamara), Lunetta, KL, Johnson, A.D. (Andrew), Brabant, G, Onland-Moret, N. Charlotte, Franks, S. (Steve), Wichmann, H-E, Pamela Ouyang, Miljkovic I, Rivadeneira, F, Bhasin, S, Murabito, J. (Joanne), Murray A, Tworoger, Shelley, Prescott J, Prokopenko I, Vaidya, Dhananjay, Gils, C.H. (Carla) van, Chen Y, Raffel, L, Chen B, Prescott, J., Kiel Douglas P., Stöckl, Doris, Hofman Albert, Nelson S, Järvelin Marjo-Riitta, Kurt Lohman, McCarthy, MI, Kähönen Mika, McCarthy Mark I., Kähönen, M, Illig T, Hannu Martikainen, Kurt Lohman (110218), Biffar, R, Ohlsson, C, Thomas Illig, Johannes Kettunen (120333), Raitakari, Olli T., Siscovick D, Homuth, G. (Georg), Johannes Kettunen, Ruokonen, A. (Aimo), Mellström D, Georg Brabant, David Karasik (150081), Perry JR, Cox, David G., Kähönen, M., Homuth G, Markus, Marcello RP, Reincke, M., van der Schouw, YT, Wellons Melissa, Dan Mellström, Fernando Rivadeneira, Jingmin Liu (150110), Tamara B. Harris (110195), Mangino, M, Guangju Zhai (110167), Rexrode, K., Kraft Peter, van der Schouw YT, Aimo Ruokonen (116631), Jansson JO, Tworoger Shelley, Jansson, JO, Martin Reincke, Ohlsson, C. (Claes), Chanock, S.J., Peeters, Petra H M, Reiner, Alex P, Chen, Yuhui, MAGGIO, Marcello Giuseppe, Illig, T., Tim D Spector, Garcia Melissa, Murabito, Joanne M., Stolk, L., Hunter, DJ, Ramachandran S Vasan, De Vivo, Immaculata, Östen Ljunggren (150116), Lohman Kurt, Harris TB, Marcello R. P. Markus (150133), Stefania Bandinelli (150002), Peeters, Petra H. M., Yong Mei Liu, Rexrode, K, Garcia, M., Lohman K, Tim D. Spector (108990), Melissa Garcia, Hofman A, Yuhui Chen, Wallaschofski, Henri, Ruokonen, Aimo, Ferrucci Luigi, Brabant Georg, Vandenput L, Haring, R. (Robin), Reiner AP, Frayling, T.M. (Timothy), Zhuang, Wei Vivian, Wood, Andrew R, Stephen M. Schwartz (38143), Kiel, Douglas P, Stöckl, D., Ruokonen Aimo, Perry, J.R.B. (John), Luigi Ferrucci (150038), Vasan, Ramachandran S., Anna-Liisa Hartikainen, Johnson AD, Vaidya Dhananjay, Leslie Raffel, Schwartz, Stephen M, Kiel, Douglas, Mattias Lorentzon, H.-Erich Wichmann (72009), Peeters, P.H., Lorentzon, Mattias,, Kiel, D.P., Coviello AD, Bhasin, S., Ouyang, P, Raitakari, Olli, Mellström, Dan,, Brabant G, Murabito, J.M., David J. Hunter (50227), Franks, S., Ruokonen, A, Petersen Ann-Kristin, Shelley Tworoger (150178), Myriam Fornage, Illig, Thomas, Rexrode, K. (Kathryn), Cummings, Steven, Pouta, A. (Anneli), Marcello R P Markus, Wei Vivian Zhuang, Jingmin Liu, De Vivo I, Ann-Kristin Petersen, Soranzo Nicole, Eriksson, Joel, Carla H. van Gils (150182), Koster Annemarie, Schwartz, Stephen M., Järvelin MR, Johnson, Andrew D., McCarthy, M.I. (Mark), Reiner Biffar, Aimo Ruokonen, Onland-Moret, NC, Schwartz, SM, Carla H van Gils, Stolk, L. (Lisette), Hankinson SE, Claes Ohlsson (1924), Coviello Andrea D., Onland-Moret, N.C. (Charlotte), Bidlingmaier, M., Lohman, Kurt, Tworoger, Shelley S., Liu YM, Martikainen, H, Zhai, G. (Guangju), Vandenput, L., Kathryn Rexrode, Kathryn L. Lunetta (149902), He C, Markus, Marcello R. P., Alexander Teumer (112757), Doris Stöckl (150177), Sarah Keildson, Chen, Brian, Vandenput, Liesbeth,, Doris Stöckl, Biffar, R., Wichmann, H Erich, Wei Vivian Zhuang (149990), Hunter, D.J., Karasik D, Fornage Myriam, Teumer, A. (Alexander), Cox David G., Garcia, Melissa E, Johnson, A.D., Lyytikäinen, L.-P., Wallaschofski, H. (Henri), David J Hunter, Biffar R, Lyytikainen, L-P, Kettunen J, Siscovick David, Jennifer Prescott (76050), Rexrode K, Brian Chen, Markus, MR, Ljunggren Östen, Hankinson Susan E., Rivadeneira Fernando, Lunetta, Kathryn L, Hartikainen, AL, Franks, S, Leo-Pekka Lyytikäinen (144253), Viikari, Jorma S., Leslie Raffel (150165), Franks, Steve, Karlsson, M., Murray, J.C. (Jeffrey), Inga Prokopenko, Viikari J, Lorentzon, M. (Mattias), Georg Homuth (110202), Timothy M Frayling, Bhasin S, Petersen, A-K, Chanock, Stephen J., Mirel, Daniel, Eriksson, J., Lisette Stolk (149967), Guangju Zhai, Andrew D. Johnson (150072), Haring, Robin, Mirel Daniel, David Siscovick, Murray, A., Schwartz, S.M. (Stephen), Jarvelin, M.-R. (Marjo-Riitta), Raitakari, O., Keildson, S, Soranzo, N., Fornage M, Kähönen, M. (Mika), Pouta, A., Karasik, D. (David), He, Chunyan, Perry, JR, Daniel Mirel, Brabant, G., Wichmann, HE, Hunter DJ, Andrea D. Coviello (149867), Yvonne T. van der Schouw (50177), Fornage, M., Martin Bidlingmaier (150187), Viikari, J. (Jorma), van der Schouw Yvonne T., Lyytikäinen Leo-Pekka, Perry, John R.B., Wellons, M. (Melissa), N Charlotte Onland-Moret, Martin Bidlingmaier, Tworoger S, Murabito, JM, Raitakari Olli, Frayling, Timothy M, Teumer, Alexander, Leo-Pekka Lyytikäinen, Chen, BPC, Ramachandran S. Vasan (110476), Illig, T, Bandinelli, S. (Stefania), Spector Tim D., He, CY, Liu, Simin, Gunter Marc J., Vasan, RS, Steven Cummings, Wellons, M, Ljunggren, Ö, Prokopenko, I, Henri Wallaschofski, Mirel, D. (Daniel), Pouta, A, van der Schouw, Yvonne T., Nicole Soranzo (12361), Spector, T.D. (Timothy), Raitakari O, Mei, Y, Maggio, M., He, C. (Chunyan), He, C, Perry, JRB, Kraft, Peter, Onland Moret NC, Liu Jingmin, Karlsson Magnus, Soranzo, Nicole, Hofman, A. (Albert), Lehtimäki T, Viikari Jorma, Wood, A.R., Albert Hofman, Fornage, M, Peeters, Petra HM, Uitterlinden André G., Pouta Anneli, Morin Papunen, Laure, Zhuang, WV, Karasik, D., Siscovick, David S, Viikari, Jorma, Cummings Steven, Homuth Georg, Keildson, Sarah, Liesbeth Vandenput, Mirel, D., Liu, Jingmin, Yuhui Chen (150020), de Vivo, I., Hannu Martikainen (150049), Schwartz, S.M., Chanock, S.J. (Stephen), Chen, YH, Alexander Teumer, Kiel DP, Vasan, R.S. (Ramachandran Srini), Morin Papunen L, Karlsson, M. (Magnus), Jorma Viikari (49741), Chunyan He, Bandinelli Stefania, Wood AR, Raffel, Leslie, Mirel, D, Vasan RS, Chen, Y., Wellons M, Östen Ljunggren, Spector, T.D., Bhasin Shalender, Iva Miljkovic (150145), Wallaschofski H, Jong, F.A. (Floris) de, Steve Franks (150205), Reiner Alex P., Reincke M, Perry, John RB, Cox, David G, Laure Morin Papunen (150157), Prescott, J, Stolk, L, Markus, MRP, Jansson, John-Olov, Lohman, Kurt K., Bandinelli S, Koster, Annemarie; id_orcid, Lagou, V. (Vasiliki), Petersen, Ann-Kristin, Zhuang Wei Vivian, Schouw, Y.T. (Yvonne) van der, He, C., Soranzo N, Susan E Hankinson, Kathryn L Lunetta, de Jong, FH, He Chunyan, Dhananjay Vaidya (149887), Biffar, Reiner, Terho Lehtimäki, Lisette Stolk, Cox, D.G., Uitterlinden AG, Marc J. Gunter (148230), Zhuang WV, Liu, YM, Reiner, AP, Rivadeneira Ramirez, F. (Fernando), Chen Yuhui, Lorentzon, M, Harris, Tamara B, Murray Anna, Magnus Karlsson (150089), Kähönen M, Stolk, Lisette, Kettunen, Johannes, Nelson, S, Wichmann, H.-E., Reincke, M, Zhai, G., Morin Papunen, L, Kiel, D.P. (Douglas), Illig Thomas, Robin Haring, Bidlingmaier, M, Hartikainen Anna-Liisa, Myriam Fornage (45591), Liu Simin, Lehtimäki, T., Melissa Garcia (113622), Nelson, S. (Sarah), Thomas Illig (44906), John-Olov Jansson (150063), Karlsson, Magnus, Wallaschofski, H, Murray, Anna, Liu, S, Raffel, L., Wallaschofski, H., Stöckl D, Vasiliki Lagou (149920), Perry, John R. B., Zhai, GJ, Lunetta, Kathryn L., Vandenput Liesbeth, Zhai Guangju, Uitterlinden, AG, Wood, Andrew R., Illig, T. (Thomas), Haring, R., David Siscovick (103766), Gunter, M.J. (Marc J.), Tamara B Harris, Koster A, Bandinelli, S., Chen, B.H. (Brian), Rivadeneira F, Liu, Yong Mei, Karlsson, Magnus,, Hankinson, Susan, Hankinson, Susan E, Liu, J, Chanock, Stephen J, Hartikainen, Anna-Liisa, Harris, Tamara, Andrew R. Wood (149984), Wichmann, H-Erich, Ruokonen A, Lagou, Vasiliki, Chunyan He (149909), Ohlsson Claes, Ouyang, P., Brian Chen (149932), Keildson Sarah, Keildson, S. (Sarah), Prescott Jennifer, Homuth, G, Petersen, A.K., Vandenput, Liesbeth, Petersen AK, Cummings, Steven R, Gunter MJ, Jarvelin, M.R., Ferrucci, L. (Luigi), Lunetta Kathryn L., Martikainen, H., Mirel D, Frank H. de Jong (150208), Eriksson, J, N. Charlotte Onland-Moret (113650), van Gils Carla H., Simin Liu, Wood, AR, Garcia M, Gunter, M.J., Annemarie Koster, Garcia, M. (Melissa), Kettunen, J. (Johannes), Reincke Martin, Eriksson J, Vaidya, D. (Dhananjay), Liu J, Koster, Annemarie, Stöckl, D. (Doris), Kiel, Douglas P., Siscovick, David, Yong Mei Liu (149948), Liu S, Soranzo, N. (Nicole), Sarah Nelson (47538), van Gils, C.H., Miljkovic, Iva, Lagou, V., Vaidya, D, Stöckl, D, Immaculata De Vivo (150192), Markus, M.R.P. (Marcello R. P.), Bandinelli, Stefania, Prokopenko, Inga, Iva Miljkovic, Peeters Petra H. M., Morin Papunen, L. (Laure), Franks S, Frayling Timothy M., Petra H M Peeters, Hunter, David J, Miljkovic, I. (Iva), Chen Brian, Raffel, L.J. (Leslie), John R B Perry, Liesbeth Vandenput (149975), Henri Wallaschofski (112750), Martin Reincke (150169), Frayling TM, Liu Yong Mei, Inga Prokopenko (43252), Lohman, K, Ferrucci, L, Markus, Marcello R P, Prescott, C.A.J., Maggio, Marcello, Olli Raitakari (144269), Uitterlinden, A.G. (André), Wellons, M., Vivo, I. (Immaculata) de, Lund University., Alex P. Reiner (113675), Luigi Ferrucci, Douglas P Kiel, de Jong, Frank H, Yvonne T van der Schouw, Coviello, AD, Ann-Kristin Petersen (149959), Mika Kähönen, Homuth, G., De Vivo, I, H-Erich Wichmann, Onland-Moret, Charlotte N, Cox, D.G. (David), Wellons, Melissa, Hankinson, S.E., Raitakari, O, Ljunggren, Östen,, Vasiliki Lagou, Anna Murray (150202), Teumer, A., Joel Eriksson, Haring Robin, Terho Lehtimäki (49739), Ouyang Pamela, Frayling, TM, Gunter, Marc J., Reiner, Alex P., Teumer, A, Susan E. Hankinson (89927), van Gils, CH, McCarthy, M.I., Peeters PH, Joanne M Murabito, Koster, A., Cummings, S, Dan Mellström (150140), Stöckl Doris, Martikainen H, Homuth, Georg, Harris, TB, van Gils, Carla H, Martikainen, H. (Hannu), Lunetta, K.L. (Kathryn), Prokopenko Inga, Chanock, SJ, Bidlingmaier, M. (Martin), Melissa Wellons (149876), van Gils, Carla H., Wichmann H.-Erich, Claes Ohlsson, Vandenput, L, Petersen, AK, André G. Uitterlinden (2213413), Laure Morin Papunen, Hofman, Albert, Jansson, John-Olov,, Teumer Alexander, Mark I McCarthy, Chen, Y, Markus Marcello R. P., Vandenput, L. (Liesbeth), Mellström, D., Jong, Frank, Sarah Nelson, Chen, B, Georg Brabant (150011), Lyytikäinen, L.-P. (Leo-Pekka), David G. Cox (89928), Vasan, R.S., Wood Andrew R., Lehtimäki, T. (Terho), Zhai G, Karasik, D, Lyytikainen, Leo-Pekka, Kettunen, J, Peeters, PHM, Stefania Bandinelli, Spector, TD, Miljkovic Iva, Lorentzon Mattias, Wallaschofski Henri, Nelson Sarah, Mattias Lorentzon (121092), Johnson, Andrew D, Gunter, MJ, Lorentzon, M., Bidlingmaier, Martin, Wichmann, H. -Erich, Brabant, G. (Georg), Siscovick, D.S. (David), Kettunen Johannes, Peeters, P.H.M., Lunetta KL, Ferrucci, L., Hartikainen, A.L., Massimo Mangino (87550), Peter Kraft, Maggio, M, Wichmann, H.E. (Erich), Liu, J., Tworoger, S. (Shelley), Stolk L, Lehtimaki, Terho, van Gils CH, Anneli Pouta (116626), van der Schouw, Yvonne T, Lehtimäki, T, De Vivo Immaculata, Lorentzon M, Hunter, David, Ljunggren Ö, Hankinson, Susan E., Eriksson, Joel,, Reincke, Martin, Martikainen, Hannu, Hofman, Bert, Hartikainen AL, Prokopenko, I. (Inga), Tworoger, S, Kraft, P., Cummings, S., Liu, Y. (YongMei), Mellström Dan, Ferrucci, Luigi, Soranzo, N, Schwartz Stephen M., Siscovick, D, Jennifer Prescott, Markus, M.R., Spector, Tim D., Coviello, Andrea D, Simin Liu (11987), Zhai, G, Stephen J Chanock, Wood, A.R. (Andrew), Jorma Viikari, Haring, R, Mika Kähönen (131499), Ohlsson, C., Chen, B., Mark I. McCarthy (145748), Gunter, Marc J, Onland-Moret, N.C., Wichmann, H.-Erich, Melissa Wellons, Uitterlinden, André, Pouta, Anneli, Kraft, P, Immaculata De Vivo, Lorentzon, Mattias, Pouta A, Nelson, Sarah, Hankinson, S.E. (Susan), Miljkovic, I., Vaidya D, Tworoger, S., Hunter, D. (David), Lyytikäinen, LP, Rivadeneira, Fernando, Steven Cummings (150028), Bidlingmaier Martin, de Jong Frank H., Chanock SJ, Jarvelin, M-R, Kathryn Rexrode (150173), Harris, T.B., Lagou V, David G Cox, Mangino, Massimo, Olli Raitakari, Ohlsson, Claes,, Liu, Y.M., Coviello, Andrea D., Lunetta, K.L., Karlsson, M, Viikari, J., Mangino M, Zhai, Guangju, Jansson, J-O, Vasan Ramachandran S., Kiel, DP, Johnson, AD, Liu, SM (Simin), Alex P Reiner, Siscovick, D., Petersen, A.-K., Petra H. M. Peeters (115139), McCarthy, Mark I., Massimo Mangino, Harris, Tamara B., Hunter, David J., Peter Kraft (15118), McCarthy MI, de Jong, Frank H., Onland-Moret, N Charlotte, Steve Franks, Cox DG, Lohman, K. (Kurt), Bindlingmaier, Martin, Pamela Ouyang (150198), Uitterlinden, André; id_orcid, Rexrode Kathryn, Timothy M. Frayling (145700), Rivadeneira, F., Chanock Stephen J., Reiner Biffar (135695), Garcia, Melissa, Viikari, J, Reiner, A.P. (Alex), Liu, S., Markus MR, Jansson, J.O., Ljunggren, O., Prokopenko, I., Magnus Karlsson, Andrew R Wood, Kraft, P. (Peter), Bhasin, Shalender, de Jong, F.H., Coviello, A.D. (Andrea), Karlsson M, Fornage, M. (Myriam), Perry John R. B., Vaidya, D., Joel Eriksson (149940), Harris Tamara B., Brabant, Georg, André G Uitterlinden, Hankinson, SE, Maggio, M. (Marcello), Shelley Tworoger, Reincke, M. (Martin), Zhuang, W.V., Nicole Soranzo, Joanne M. Murabito (150212), Annemarie Koster (66337), Mangino, M. (Massimo), Nelson, S., Spector, Tim D, Uitterlinden, A.G., Karasik, David, Teumer A, John R. B. Perry (150215), Eriksson Joel, Wichmann, Heinz-Erich, Biffar, R. (Reiner), Robin Haring (149871), Franks Steve, Ohlsson C, Anna Murray, Ouyang P, Peeters, PH, Keildson S, Hartikainen, A-L, Ferrucci L, Spector TD, Koster, A. (Annemarie), Lagou Vasiliki, Raffel Leslie, Lagou, V, Georg Homuth, Shalender Bhasin, Haring R, de Jong FH, Raitakari, O. (Olli), Marcello Maggio (150126), Hofman, A, Kraft P, Perry, John R B, Frayling, T.M., Albert Hofman (107303), Garcia, M, Onland-Moret N. Charlotte, Andrea D Coviello, Bidlingmaier M, Andrew D Johnson, Ouyang, P. (Pamela), Morin Papunen, L., Raffel L, Bhasin, S. (Shalender), Eriksson, J. (Joel), Mellström, D. (Dan), Murabito, Joanne M, Lohman, K., Marjo-Riitta Järvelin, Anna-Liisa Hartikainen (110272), Marjo-Riitta Järvelin (2141947), Ohlsson, Claes, Kettunen, J., Morin Papunen Laure, Papunen, LM, Jansson John-Olov, Johnson Andrew D., Maggio Marcello, Fernando Rivadeneira (61551), Sarah Keildson (149896), Karasik David, Uitterlinden, Andre G., Ljunggren, Osten, Jarvelin, Marjo-Riitta, Mellstrom, Dan, Kahonen, Mika +864 morecore +2 more sourcesHMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence
Advanced Science, EarlyView.In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni +19 morewiley +1 more source
