Results 51 to 60 of about 1,914,121 (297)

Functional role of THRAP3 in modulating thyroid hormone-mediated gene networks in C2C12 myotubes.

PLoS ONE
Thyroid hormone (TH) secreted by the thyroid gland plays essential roles in regulating metabolism, development, and nervous system function. Thyroid hormone receptor-associated protein 3 (THRAP3) is a nuclear coactivator that interacts with the thyroid ...
Taku Fukushima, Sachi Kuse, Yuka Hasegawa, Taiju Fujioka, Takeshi Nikawa, Satoru Masubuchi, Iori Sakakibara   +6 more
doaj   +1 more source

The hinge region of human thyroid-stimulating hormone (TSH) receptor operates as a tunable switch between hormone binding and receptor activation. [PDF]

PLoS ONE, 2012
The mechanism by which the hinge regions of glycoprotein hormone receptors couple hormone binding to activation of downstream effecters is not clearly understood.
Ritankar Majumdar, Rajan R Dighe
doaj   +1 more source

Steroid and Thyroid Hormone Receptors

Endocrinology and Metabolism Clinics of North America, 1991
The identification, cloning, and characterization of steroid and thyroid hormone receptors have revealed much about the mechanisms of hormone action. While their remarkable similarities reflect evolutionary conservation of useful structural and functional motifs, differences in their gene number and organization, mRNA regulation, nuclear localization ...
openaire   +2 more sources

The product of a thyroid hormone-responsive gene interacts with thyroid hormone receptors [PDF]

Proceedings of the National Academy of Sciences, 1997
Thyroid hormone is a critical mediator of central nervous system (CNS) development, acting through nuclear receptors to modulate the expression of specific genes. Transcription of the rat hairless ( hr ) gene is highly up-regulated by thyroid hormone in
C C, Thompson, M C, Bottcher
openaire   +2 more sources

RESISTANCE TO THYROID HORMONE DUE TO A NOVEL THR- MUTATION IN A PATIENT WITH THYROID AGENESIS

, 2018
Refetoff Syndrome is a rare disorder characterized by resistance to thyroid hormone (RTH). The coexistence of RTH and thyroid dysgenesis is a rare event. Up to now, only four cases of ectopic gland and RTH have been reported.
Maria Scavone
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

A Mutation in the Thyroid Hormone Receptor Alpha Gene

, 2012
Thyroid hormones exert their effects through alpha (TRα1) and beta (TRβ1 and TRβ2) receptors. Here we describe a child with classic features of hypothyroidism (growth retardation, developmental retardation, skeletal dysplasia, and severe constipation ...
I. S. Farooqi (7604078), D. Halsall (7604075), M. Sarri (7604102), F. Muntoni (7604117), A. Offiah (7604090), E. Schoenmakers (7604060), E. Bochukova (7604051), F. V. Khadem (7604105), J. Reinemund (7604072), E. Henning (7604069), O. Rajanayagam (7604063), K. Chatterjee (7604084), M. Dattani (7604099), K. Downes (7604087), A. Albanese (7604111), N. Schoenmakers (7604054), J. M. Keogh (7604066), John W. R. Schwabe (7604093), E. Gevers (7604096), K. Lindley (7604108), M. Agostini (7604057), M. Gurnell (7604081), M. Bain (7604114), Halsall, David, Maura Agostini, David Halsall, Lindley, Keith, Nadia Schoenmakers, Muntoni, Francesco, Henning, Elana, Sarri, Margarita, Odelia Rajanayagam, Murray Bain, Farooqi, I. Sadaf, Kate Downes, Schoenmakers, Erik; id_orcid, Evelien Gevers, Faraneh Vargha-Khadem, Jana Reinemund, Rajanayagam, Odelia, Offiah, Amaka, Keogh, Julia M., Amaka Offiah, Bochukova, Elena, Margarita Sarri, Keith Lindley, Gurnell, Mark, Francesco Muntoni, Reinemund, Jana, Mehul Dattani, Agostini, Maura, Erik Schoenmakers, Dattani, Mehul, Chatterjee, Krishna, Khadem, Faraneh Vargha, Schoenmakers, Nadia, John W.R. Schwabe, Elana Henning, Schwabe, John W.R., Julia M. Keogh, I. Sadaf Farooqi, Krishna Chatterjee, Assunta Albanese, Downes, Kate, Mark Gurnell, Albanese, Assunta, Gevers, Evelien, Bain, Murray, Elena Bochukova   +68 more
core   +5 more sources

Design and synthesis of novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives as thyroid hormone receptor β (TR-β) selective ligands

, 2008
Design and synthesis of a novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives are reported and their in vitro thyroid hormone receptor selectivity has been evaluated in the thyroid luciferase receptor assay.
Soni, Krunal, Raval, Preeti, Joharapurkar, A., Bandyopadhyay, Debdutta, Yevale, Digambar, Raval, S., Soni, K., Gandhi, Neha, Raval, P., Jain, Mukul R., Modi, H., Modi, Honey, Yevale, D., Bandyopadhyay, D., Jain, M., Jogiya, Digvijay, Raval, Saurin, Joharapurkar, Amit, Patel, P., Jogiya, D., Patel, Pankaj R.   +20 more
core   +1 more source

TREM2 is Thyroid Hormone Regulated Making the TREM2 Pathway Druggable with Ligands for Thyroid Hormone Receptor. [PDF]

, 2021
Triggering receptor expressed on myeloid cells-2 (TREM2) is a cell surface receptor on macrophages and microglia that senses and responds to disease-associated signals to regulate the phenotype of these innate immune cells.
Brooke A. Napier, Priya Chaudhary, Calkins, Evan, Pocius, Edvinas, Hannah Miller, Skylar J. Ferrara, Margaret J. DeBell, Thomas S. Scanlan, Edvinas Pocius, Miller, Hannah, Ben Emery, Ferrara, Skylar J, Gail Marracci, Dennis Bourdette, Scanlan, Thomas S, Emery, Ben, Bourdette, Dennis, Evan Calkins, Marracci, Gail, Napier, Brooke A, DeBell, Margaret J, Chaudhary, Priya   +21 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source