Results 31 to 40 of about 39,898 (284)

Thyroid Hormone Resistant Syndrome

Medical Journal of Southern California Clinicians, 2020
Thyroid hormone resistance (THR), also known as resistance to thyroid hormone (RTH), is an inherited condition characterized by reduced end-organ responsiveness to thyroid hormone, caused by mutations in the thyroid hormone receptor gene. Patients typically present with elevated thyroid hormone levels (T3 and T4) with normal, or slightly elevated ...
Karo Gyurjian, Vishwanath Venketaraman
openaire   +1 more source

Syndrome of Resistance to Thyroid Hormone: Insights into Thyroid Hormone Action

Experimental Biology and Medicine, 1996
Thyroid hormones (T3, T4) exert multiple cellular effects through nuclear thyroid hormone receptors (TR alpha, TR beta). Thyroid hormone receptors are transcription factors that act by altering patterns of gene expression. Resistance to thyroid hormone (RTH) is a rare disorder caused by mutations in the TR beta gene.
P, Kopp, K, Kitajima, J L, Jameson
openaire   +2 more sources

A two-day-old hyperthyroid neonate with thyroid hormone resistance born to a mother with well-controlled Graves’ disease: a case report

Journal of Medical Case Reports, 2012
Introduction Resistance to thyroid hormone is a syndrome caused by thyroid hormone receptor β mutations, which are usually inherited in an autosomal-dominant pattern.
Yatsuga Shuichi, Hiromatsu Yuji, Sasaki Shigekazu, Nakamura Hirotoshi, Katayama Koju, Nishioka Junko, Koga Yasutoshi   +6 more
doaj   +1 more source

SYNDROME OF RESISTANCE TO THYROID HORMONE

Journal of the ASEAN Federation of Endocrine Societies, 2023
INTRODUCTION/BACKGROUNDResistance to thyroid hormone (RTH) is a rare genetic disorder characterized by clinically mild hyperthyroidism and biochemically elevated circulating free thyroid hormone levels with unsuppressed serum thyroid stimulating hormone.
openaire   +1 more source

The effects of bed rest and countermeasure exercise on the endocrine system in male adults: Evidence for immobilization-induced reduction in sex hormone-binding globulin levels [PDF]

, 2012
Background and Aim. There is limited data on the effects of inactivity (prolonged bed-rest) on parameters of endocrine and metabolic function; we therefore aimed to examine changes in these systems during and after prolonged (56-day) bed-rest in male ...
Rittweger, Jörn, Roth, H.J., Armbrecht, Gabriele, Felsenberg, Dieter, Seibel, Markus, Belavy, Daniel Ludovic   +5 more
core   +1 more source

Effects of Slow-Acting Metformin Treatment on the Hormonal and Morphological Thyroid Profile in Patients with Insulin Resistance

Pharmaceutics, 2022
Metformin appears to reduce TSH levels in untreated hypothyroid patients. In contrast, in euthyroid patients with type 2 diabetes mellitus (T2DM), metformin is initially devoid of effects on TSH.
Rosita A. Condorelli, Rossella Cannarella, Antonio Aversa, Livia Basile, Ottavia Avola, Aldo E. Calogero, Sandro La Vignera   +6 more
doaj   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Resistance to Thyroid Hormone (RTH)

, 2004
The syndrome of resistance to thyroid hormone (RTH) is characterized by reduced tissue responsiveness to thyroid hormone (TH) despite elevated circulating levels of free triiodothyronine (T3) and thyroxine (T4).
Roy E. Weiss, Gisah Amaral de Carvalho, de Carvalho, Gisah Amaral, Weiss, Roy E   +3 more
core   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Thyroid Hormone Resistance due to a Novel De Novo Mutation in Thyroid Hormone Receptor Alpha: First Case Report from the Middle East and North Africa

Oman Medical Journal, 2021
The physiological actions of thyroid hormone (TH) are mediated through TH alpha and TH beta receptors. Resistance to TH (RTH) is characterized by a lack of peripheral tissues’ response to the active form of TH.
Azza Al Shidhani, Irfan Ullah, Hussain AlSaffar, Adila Al Kindi, Hameeda Al Nabhani, Saif Al Yaarubi   +5 more
doaj   +1 more source