Results 31 to 40 of about 3,775,070 (185)

Placental transfer of a hydroxylated polychlorinated biphenyl and effects on fetal and maternal thyroid hormone homeostasis in the rat [PDF]

open access: yes, 2002
Earlier studies at our laboratory indicated that several hydroxylated polychlorinated biphenyls (OH-PCBs) detected in human blood could specifically inhibit thyroxine (T4) transport by competitive binding to the thyroid hormone transport protein ...
Bergman, A.   +11 more
core   +2 more sources

A two-day-old hyperthyroid neonate with thyroid hormone resistance born to a mother with well-controlled Graves’ disease: a case report

open access: yesJournal of Medical Case Reports, 2012
Introduction Resistance to thyroid hormone is a syndrome caused by thyroid hormone receptor β mutations, which are usually inherited in an autosomal-dominant pattern.
Yatsuga Shuichi   +6 more
doaj   +1 more source

Thyroid Hormone Resistant Syndrome

open access: yesMedical Journal of Southern California Clinicians, 2020
Thyroid hormone resistance (THR), also known as resistance to thyroid hormone (RTH), is an inherited condition characterized by reduced end-organ responsiveness to thyroid hormone, caused by mutations in the thyroid hormone receptor gene. Patients typically present with elevated thyroid hormone levels (T3 and T4) with normal, or slightly elevated ...
Karo Gyurjian, Vishwanath Venketaraman
openaire   +1 more source

Thyroid hormone resistance syndrome. Inhibition of normal receptor function by mutant thyroid hormone receptors. [PDF]

open access: yesJournal of Clinical Investigation, 1991
Thyroid hormone (T3) resistance is inherited in most cases in an autosomal dominant manner. The disorder is characterized by elevated free thyroid hormone levels and partial resistance to thyroid hormone at the cellular level. Distinct single amino acid substitutions in the ligand binding domain of the beta form of the thyroid hormone receptor have ...
Chatterjee, V. Krishna K.   +5 more
openaire   +3 more sources

A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone-Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation [PDF]

open access: yes, 2012
Sex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and biologic availability of sex steroid hormones, primarily testosterone and estradiol.
Frank H de Jong   +864 more
core   +2 more sources

Resistance to thyroid hormone accompanied by atrial fibrillation

open access: yesEndocrinology, Diabetes & Metabolism Case Reports, 2018
Resistance to thyroid hormone (RTH), which is primarily caused by mutations in the thyroid hormone (TH) receptor beta (THRB) gene, is dominantly inherited syndrome of variable tissue hyposensitivity to TH.
Haruhiro Sato, Yuichiro Tomita
doaj   +1 more source

Syndromes of resistance to thyroid hormone

open access: yesClinical and experimental thyroidology, 2013
Синдром резистентности к тиреоидным гормо нам (RTH) является наследственным синдромом, характеризующимся пониженной чувствительнос тью тканеймишеней к гормонам щитовидной желе зы. RTH впервые был описан в 1967 году как часть семейного синдрома, включающего глухонемоту, зоб и аномально повышенный уровень тиреоидных гор монов на фоне нормальной ...
V A Kaldymova, A V Kiyaev, A N Tyulpakov
openaire   +2 more sources

Resistance to thyroid hormone induced tachycardia in RTHα syndrome

open access: yesNature Communications, 2023
Mutations in thyroid hormone receptor α1 (TRα1) cause Resistance to Thyroid Hormone α (RTHα), a disorder characterized by hypothyroidism in TRα1-expressing tissues including the heart.
Riccardo Dore   +23 more
doaj   +1 more source

Effects of Thyroxine Exposure on Osteogenesis in Mouse Calvarial Pre-Osteoblasts [PDF]

open access: yes, 2013
The incidence of craniosynostosis is one in every 1,800-2500 births. The gene-environment model proposes that if a genetic predisposition is coupled with environmental exposures, the effects can be multiplicative resulting in severely abnormal phenotypes.
Mohammed Elsalanty   +19 more
core   +2 more sources

The zebrafish model to identify new genes involved in thyroid development [PDF]

open access: yes, 2010
Thyroid organogenesis is a very complex developmental process that leads to the formation of an organ able to produce specific hormones through specification, migration, structural organization and functional differentiation of thyroid precursor cells ...
Porreca, Immacolata
core   +1 more source

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