Results 21 to 30 of about 39,493 (235)

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Syndrome of Resistance to Thyroid Hormone: Insights into Thyroid Hormone Action

Experimental Biology and Medicine, 1996
Thyroid hormones (T3, T4) exert multiple cellular effects through nuclear thyroid hormone receptors (TR alpha, TR beta). Thyroid hormone receptors are transcription factors that act by altering patterns of gene expression. Resistance to thyroid hormone (RTH) is a rare disorder caused by mutations in the TR beta gene.
P, Kopp, K, Kitajima, J L, Jameson
openaire   +2 more sources

Thyroid Hormone Resistant Syndrome

Medical Journal of Southern California Clinicians, 2020
Thyroid hormone resistance (THR), also known as resistance to thyroid hormone (RTH), is an inherited condition characterized by reduced end-organ responsiveness to thyroid hormone, caused by mutations in the thyroid hormone receptor gene. Patients typically present with elevated thyroid hormone levels (T3 and T4) with normal, or slightly elevated ...
Karo Gyurjian, Vishwanath Venketaraman
openaire   +1 more source

中国甲状腺功能正常人群对甲状腺激素的敏感性和代谢综合征组分的风险

Journal of Diabetes, 2023
Introduction To evaluate the association of sensitivity to thyroid hormone with metabolic syndrome (MetS) and its components in a Chinese euthyroid population. Methods A total of 3573 participants from Pinggu Metabolic Disease Study were analyzed.
Fang Lv, Xiaoling Cai, Yufeng Li, Xiuying Zhang, Xianghai Zhou, Xueyao Han, Linong Ji   +6 more
doaj   +1 more source

Thyroid hormone resistance syndrome [PDF]

, 2011
Abstract Thyroid hormones (thyroxine T4 and triiodothyronine T3) regulate many cellular processes in virtually every type of tissue. The diverse effects of thyroid hormone include regulation of growth, control of basal metabolic rate, enhanced myocardial contractility, and functional differentiation of the central nervous system.
Mark Gurnell, V. Krishna Chatterjee
openaire   +1 more source

SYNDROME OF RESISTANCE TO THYROID HORMONE

Journal of the ASEAN Federation of Endocrine Societies, 2023
INTRODUCTION/BACKGROUNDResistance to thyroid hormone (RTH) is a rare genetic disorder characterized by clinically mild hyperthyroidism and biochemically elevated circulating free thyroid hormone levels with unsuppressed serum thyroid stimulating hormone.
openaire   +1 more source

A two-day-old hyperthyroid neonate with thyroid hormone resistance born to a mother with well-controlled Graves’ disease: a case report

Journal of Medical Case Reports, 2012
Introduction Resistance to thyroid hormone is a syndrome caused by thyroid hormone receptor β mutations, which are usually inherited in an autosomal-dominant pattern.
Yatsuga Shuichi, Hiromatsu Yuji, Sasaki Shigekazu, Nakamura Hirotoshi, Katayama Koju, Nishioka Junko, Koga Yasutoshi   +6 more
doaj   +1 more source

Thyroid hormone resistance syndrome. Inhibition of normal receptor function by mutant thyroid hormone receptors. [PDF]

Journal of Clinical Investigation, 1991
Thyroid hormone (T3) resistance is inherited in most cases in an autosomal dominant manner. The disorder is characterized by elevated free thyroid hormone levels and partial resistance to thyroid hormone at the cellular level. Distinct single amino acid substitutions in the ligand binding domain of the beta form of the thyroid hormone receptor have ...
Chatterjee, V. Krishna K., Nagaya, Takashi, Madison, Laird D., Datta, Shoumen, Rentoumis, Anne, Jameson, Larry J.   +5 more
openaire   +3 more sources

Resistance to thyroid hormone induced tachycardia in RTHα syndrome

Nature Communications, 2023
Mutations in thyroid hormone receptor α1 (TRα1) cause Resistance to Thyroid Hormone α (RTHα), a disorder characterized by hypothyroidism in TRα1-expressing tissues including the heart.
Riccardo Dore, Laura Watson, Stefanie Hollidge, Christin Krause, Sarah Christine Sentis, Rebecca Oelkrug, Cathleen Geißler, Kornelia Johann, Mehdi Pedaran, Greta Lyons, Nuria Lopez-Alcantara, Julia Resch, Friedhelm Sayk, Karl Alexander Iwen, Andre Franke, Teide Jens Boysen, Jeffrey W. Dalley, Kristina Lorenz, Carla Moran, Kirsten L. Rennie, Anders Arner, Henriette Kirchner, Krishna Chatterjee, Jens Mittag   +23 more
doaj   +1 more source

Resistance to thyroid hormone accompanied by atrial fibrillation

Endocrinology, Diabetes & Metabolism Case Reports, 2018
Resistance to thyroid hormone (RTH), which is primarily caused by mutations in the thyroid hormone (TH) receptor beta (THRB) gene, is dominantly inherited syndrome of variable tissue hyposensitivity to TH.
Haruhiro Sato, Yuichiro Tomita
doaj   +1 more source