Monocarboxylate transporter 8 modulates the viability and invasive capacity of human placental cells and fetoplacental growth in mice [PDF]
Monocarboxylate transporter 8 (MCT8) is a well-established thyroid hormone (TH) transporter. In humans, MCT8 mutations result in changes in circulating TH concentrations and X-linked severe global neurodevelopmental delay.
Laurence S Loubière +83 more
core +2 more sources
Thyroid-like function in the urochordate Ciona intestinalis [PDF]
In the studies reported in the manuscript I investigated the involvement of Iodine and thyroxine (Thyroid Hormone, T4) in Ciona intestinalis metamorphosis. To date, the mechanisms regulating the metamorphosis of ascidians remain largely unknown.
Staiano, Leopoldo
core +1 more source
Involvement of the hypothalamic-pituitary-thyroid axis and its interaction with the hypothalamic-pituitary-adrenal axis in the ontogeny of avian thermoregulation: a review [PDF]
The emergence of thermoregulation in avian species is a complex matter in which neural as well as hormonal processes are involved. In a previous paper, the neural aspects of primary avian thermoregulation were discussed.
Brand, H., van den +5 more
core +1 more source
THYROID HORMONE RESISTANCE SYNDROME (THR)
INTRODUCTION/BACKGROUNDThyroid hormone resistance syndrome (THR) is a rare condition caused by defects in either one of the two thyroid hormone receptors which leads to tissue unresponsiveness to circulating thyroid hormones. The presentations vary depending on which receptor is affected.
W Mohd Hilmi bin W. Omar +2 more
openaire +1 more source
Sensitivity to thyroid hormones in Egyptian euthyroid patients with metabolic syndrome
Background Metabolic syndrome (MetS) is a common metabolic and endocrine disease, and many studies have found that thyroid disorders, both overt and subclinical, might be accompanied by the risk of MetS. Objectives Assessment of indices of sensitivity to
Heba Ibrahim Selim +2 more
doaj +1 more source
TRH: Pathophysiologic and clinical implications [PDF]
Thyrotropin releasing hormone is thought to be a tonic stimulator of the pituitary TSH secretion regulating the setpoint of the thyrotrophs to the suppressive effect of thyroid hormones. The peptide stimulates the release of normal and elevated prolactin.
Pickardt, C. R., Scriba, Peter Christian
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Is There an Association between Thyroid Disease and Metabolic Syndrome [PDF]
Background: The metabolic syndrome and thyroid dysfunctions are the two most prevalent endocrine illnesses, and they significantly overlap. Due to their strong associations with morbidity and mortality, both have a huge global influence on health care ...
Nermin Ghanem +3 more
doaj +1 more source
Thyroid hormone resistance syndrome – own experiences
Thyroid hormone resistance syndrome, also known as Refetoff syndrome, is a rare disease associated with decreased reaction of body tissues to thyroid hormones (TH). Patients with Refetoff syndrome tend to have elevated free TH concentrations and normal or inadequately elevated TSH (caused by thyrotropic cells in the pituitary gland insensitivity to TH).
Tomasz, Jackowski +3 more
openaire +2 more sources
Resistance to Thyroid Hormone in the Absence of Mutations in the Thyroid Hormone Receptor Genes
Resistance to thyroid hormone (RTH) is a syndrome of reduced tissue sensitivity to thyroid hormone. In the majority of subjects, RTH is caused by mutant thyroid hormone receptors (TR) ß molecules that interfere with the function of the normal TRß, thus ...
Refetoff, Samuel +6 more
core +1 more source
Mechanism of thyroid-hormone regulated expression of the SERCA genes in skeletal muscle: Implications for thermogenesis [PDF]
Thyroid hormone increases the Ca2+-ATPase activity of the sarcoplasmic reticulum (SR) in skeletal muscle, thereby increasing the energy-turnover associated with Ca2+-cycling during contraction and rest. The fast-muscle isoform of the Ca2+-ATPase (SERCA1)
Hardeveld, C. +9 more
core +1 more source

