Results 61 to 70 of about 39,898 (284)

Audiological alterations in resistance to thyroid hormone syndrome: emphasizing lifelong assessment [PDF]

Archives of Endocrinology and Metabolism
The aim of this study was to investigate the long-term audiological consequences of resistance to thyroid hormone (RTH) syndrome. The cochlea and inner ear express thyroid hormone receptor beta (THRB) in developmental stages.
Alexandre Machado Silva de Oliveira, Viviane Motti, Jessica Casemiro, Pedro Resende Rende, Caio Leônidas Oliveira de Andrade, Luciene da Cruz Fernande, Helton Estrela Ramos   +6 more
doaj   +1 more source

Effect of thyroid hormone on growth. Lessons from the syndrome of resistance to thyroid hormone

, 1996
Thyroid hormone deprivation results in deleterious effects on bone growth. The delayed bone development is mediated by a direct effect of thyroid hormone on bone and an indirect effect of the hormone on GH release and IGF-1 action.
Weiss, R E, Refetoff, S
core   +1 more source

A post hoc analysis of linaclotide in pediatric patients with functional constipation and neurodevelopmental disorders

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Functional constipation (FC) is common in children with comorbid neurodevelopmental disorders (NDD) and its optimal treatment may be challenged by adherence and medication tolerability issues in this population. We assessed the efficacy and safety of linaclotide in pediatric patients with FC and NDD.
Hannibal Person, Jeffrey S. Hyams, Rinarani M. Sanghavi, Valentina Shakhnovich, Katherine Kosch, Moming Li, Danielle D'Achino, Julie Khlevner, Bruno P. Chumpitazi, Miguel Saps   +9 more
wiley   +1 more source

Clinical Characteristics and Genotype-phenotype Correlation in Turkish Patients with a Diagnosis of Resistance to Thyroid Hormone Beta [PDF]

Objective: Resistance to thyroid hormone beta (RTHβ) is a rare disorder characterized by a fairly heterogeneous clinical presentation due to varying degrees of tissue response to thyroid hormone.
Çavdarlı, Büşranur, Mehmet Boyraz, Boyraz, Mehmet, Büşranur Çavdarlı, Nur Semerci Gündüz, cakal, erman, Oya Topaloğlu, Gündüz, C.Nur Semerci, Sema Hepşen, Demirbilek, Huseyin, Erman Çakal, gürbüz, fatih, Aydın, Cevdet, Koca, Serkan bilge, Keziban Toksoy Adıgüzel, topaloglu, oya, Cevdet Aydın, Fatih Gürbüz, Hüseyin Demirbilek, Serkan Bilge Koca, HEPŞEN, SEMA, Toksoy, Keziban, Buyukyilmaz, Gonul, Gönül Büyükyılmaz   +23 more
core   +1 more source

Exploration of a Multimodal Machine Learning Model Integrating Ultrasound and Clinical Indicators for the Diagnosis of Diabetic Peripheral Neuropathy

Journal of Ultrasound in Medicine, EarlyView.
Objectives Based on ultrasound technology and clinical indicators, this study intends to develop multiple risk prediction models for diabetic peripheral neuropathy (DPN), conduct comparative analyses of these models, and further evaluate and validate the diagnostic efficacy of the optimal model for DPN as well as its potential in clinical application ...
Bo‐yu She, Meng‐lu Song, Wen‐bin Chen, Kun‐bin Wu, Zhen‐han Lai   +4 more
wiley   +1 more source

Hypercholesterolemia in Two Siblings with Resistance to Thyroid Hormones Due to Disease-Causing Variant in Thyroid Hormone Receptor (THRB) Gene

Medicina, 2020
Resistance to thyroid hormone beta (RTHβ) is a syndrome characterized by a reduced response of target tissues to thyroid hormones. In 85% of cases, a pathogenic mutation in the thyroid hormone receptor beta (THRB) gene is found.
Maja Pajek, Magdalena Avbelj Stefanija, Katarina Trebusak Podkrajsek, Jasna Suput Omladic, Mojca Zerjav Tansek, Tadej Battelino, Urh Groselj   +6 more
doaj   +1 more source

Metabolic Dysfunction‐Associated Steatotic Liver Disease and Obesity: Pathogenesis, Diagnostics, Risk Stratification, and Therapeutic Approach

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as the most prevalent chronic liver disease worldwide, closely linked to the global rising incidence of obesity and metabolic syndrome. This review synthesizes current evidence on the pathogenesis, gut–liver axis, and multidisciplinary management of MASLD within the ...
Beom Kyung Kim
wiley   +1 more source

Painless destructive thyroiditis in a patient with resistance to thyroid hormone: a case report

Thyroid Research, 2019
Background Resistance to thyroid hormone (RTH) usually features a syndrome of inappropriate secretion of thyroid-stimulating hormone (SITSH) without suppression of the typical high thyroid hormone levels.
Tomoko Nagamine, Jaeduk Yoshimura Noh, Naoya Emoto, Takahito Kogai, Akira Hishinuma, Fumitaka Okajima, Hitoshi Sugihara   +6 more
doaj   +1 more source

A new TRβ mutation in resistance to thyroid hormone syndrome [PDF]

Hormones, 2016
Thyroid hormones (TH) exert their actions by binding nuclear receptors alpha (TRα1) and beta (TRß1 and TRß2). Resistance to thyroid hormone (RTH) is a clinical syndrome with various clinical manifestations, its hallmark being decreased tissue sensitivity to the action of thyroid hormones.
Corina, Neamţu, Claudiu, Ţupea, Diana, Păun, Anca, Hoisescu, Adina, Ghemigian, Samuel, Refetoff, Chutintorn, Sriphrapradang   +6 more
openaire   +2 more sources

Lipid Profile in Primary Aldosteronism: Cross‐Sectional and Post‐Treatment Analyses

Lipids, EarlyView.
ABSTRACT The relationship between primary aldosteronism (PA) and lipid metabolism remains controversial, with inconsistent findings reported in the literature. This study aimed to clarify PA's impact on the lipid profile using both a cross‐sectional comparison with essential hypertension (EH) controls and a longitudinal within‐patient pre‐post ...
Meriem Yazidi, Arige Abid, Chayma Bel hadj Sliman, Elyes Kamoun, Ibtissem Oueslati, Fatma Chaker, Nadia Khessairi, Melika Chihaoui   +7 more
wiley   +1 more source