Results 81 to 90 of about 233 (110)

In vivo effects of repeated thyronamine (T0AM) administration in mice

Endocrine Abstracts, 2016
Jens Mittag, Lutz Schomburg, Lisbeth Harder   +2 more
exaly   +2 more sources

Novel Thyroxine Derivatives, Thyronamine and 3-iodothyronamine, Induce Transient Hypothermia and Marked Neuroprotection Against Stroke Injury [PDF]

Stroke, 2007
Background and Purpose— Mild hypothermia confers profound neuroprotection in ischemia. We recently discovered 2 natural derivatives of thyroxine, 3-iodothyronamine (T 1 AM) and thyronamine (T 0 AM), that when administered to rodents lower body ...
David K. Grandy, Kristian P Doyle, Thomas S Scanlan   +2 more
exaly   +3 more sources

Thyronamine derivatives and analogs and methods of use thereof

2005
James R Bunzow, Thomas S Scanlan
exaly   +8 more sources

Thyronamines Inhibit Plasma Membrane and Vesicular Monoamine Transport

ACS Chemical Biology, 2007
Thyroid hormone has long been known to have important transcriptional regulatory activities. Recently, however, the presence of endogenous derivatives of thyroid hormone, thyronamines, has been reported in various mammalian tissues. These derivatives have potent in vitro activity with a class of orphan G-protein-coupled receptors, the trace amine ...
Aaron N, Snead, Magda S, Santos, Rebecca P, Seal, Motonori, Miyakawa, Robert H, Edwards, Thomas S, Scanlan   +5 more
openaire   +2 more sources

Thyronamine induces TRPM8 channel activation in human conjunctival epithelial cells

Cellular Signalling, 2015
3-Iodothyronamine (T1AM), an endogenous thyroid hormone (TH) metabolite, induces numerous responses including a spontaneously reversible body temperature decline. As such an effect is associated in the eye with increases in basal tear flow and thermosensitive transient receptor potential melastatin 8 (TRPM8) channel activation, we determined in human ...
Noushafarin, Khajavi, Peter S, Reinach, Nefeli, Slavi, Marek, Skrzypski, Alexander, Lucius, Olaf, Strauß, Josef, Köhrle, Stefan, Mergler   +7 more
openaire   +2 more sources

Thyronamines and Analogues - The Route from Rediscovery to Translational Research on Thyronergic Amines

Molecular and Cellular Endocrinology, 2017
Thyronamines are a novel class of endogenous signaling compounds, structurally related to thyroid hormones (THs). Specific thyronamines, particularly 3-iodothyronamine (T1AM), stimulate with nanomolar affinity trace amine-associated receptor 1 (TAAR1), a G protein-coupled membrane receptor, and may also interact with other TAAR subtypes (particularly ...
Chiellini, Grazia, Bellusci, Lorenza, Sabatini, Martina, Zucchi, Riccardo   +3 more
openaire   +3 more sources

Does the aromatic l-amino acid decarboxylase contribute to thyronamine biosynthesis?

Molecular and Cellular Endocrinology, 2012
Thyronamines (TAM), recently described endogenous signaling molecules, exert metabolic and pharmacological actions partly opposing those of the thyromimetic hormone T(3). TAM biosynthesis from thyroid hormone (TH) precursors requires decarboxylation of the L-alanine side chain and several deiodination steps to convert e.g.
Hoefig C. S., Renko K., Piehl S., Scanlan T. S., BERTOLDI, Mariarita, Opladen T., Hoffman G. F., Klein J., Blankenstein O., Schweizer U., Koehrle J.   +10 more
openaire   +2 more sources

Trace Amine-Associated Receptor Agonists:  Synthesis and Evaluation of Thyronamines and Related Analogues

Journal of Medicinal Chemistry, 2006
We have previously shown that several thyronamines, decarboxylated and deiodinated metabolites of the thyroid hormone, potently activate an orphan G protein-coupled receptor in vitro (TAAR1) and induced hypothermia in vivo on a rapid time scale [Scanlan, T. S.; Suchland, K. L.; Hart, M. E.; Chiellini, G.; Huang, Y.; Kruzich, P.
Matthew E, Hart, Katherine L, Suchland, Motonori, Miyakawa, James R, Bunzow, David K, Grandy, Thomas S, Scanlan   +5 more
openaire   +2 more sources

Development of a validated liquid chromatography/tandem mass spectrometry method for the distinction of thyronine and thyronamine constitutional isomers and for the identification of new deiodinase substrates

Rapid Communications in Mass Spectrometry, 2008
Abstract Thyronines (THs) and thyronamines (TAMs) are two groups of endogenous iodine‐containing signaling molecules whose representatives differ from each other only regarding the number and/or the position of the iodine atoms.
Susanne, Piehl, Thomas, Heberer, Gabor, Balizs, Thomas S, Scanlan, Josef, Köhrle   +4 more
openaire   +2 more sources

Antioxidant effects of the synthetic thyronamine analogue in experimental cerebral ischemia

Medicine of Extreme Situations
The oxidative stress associated with ischemic stroke is a major factor damaging the nervous tissue. Thyroid hormones have a significant effect on the body’s redox status, however, the impact of their derivatives, thyronamines, considered as potential neuroprotectors, on the characteristics of lipid peroxidation (LP) is not clearly understood. The study
DA Filimonov, AB Eresko, EV Raksha, NN Trubnikova, RV Ischenko, DA Tereschenko, IA Kisilenko, IN Nosova   +7 more
exaly   +2 more sources