Results 41 to 50 of about 725,960 (242)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Investigation of the microstructural evolution in Ti-6A1-4V alloy during cyclic hydrogenation and dehydrogenation heat treatment [PDF]

, 2008
Includes abstract.Includes bibliographical references (leaves 87-90).The temporary alloying process involves a two stage heat treatment during which hydrogen is firstly introduced into the titanium sample (hydrogenation), and secondly removed from the ...
Oguh, Jeremiah Chika
core   +1 more source

Tailorable copper-bearing titanium alloys with remarkable strength and ductility fabricated by spark plasma sintering for biomedical applications

Journal of Materials Research and Technology
Titanium and Ti-based alloys are widely used metallic biomaterials, however, the surgical infections related to bacteria always occur on the implants. Developing the antibacterial titanium alloys has been studied as one of the most effective methods to ...
Zhanfei Wang, Yaoxin Huo, Ying Qin, Ruipeng Guo, Jinling Zhang, Changjiang Zhang, Min Cheng, Lifeng Zhang, Chao Cai, Yusheng Shi   +9 more
doaj   +1 more source

Effect of α+β solution treatment and aging on the performance of powder forged Ti-5Al-2.5Fe

Heat Treatment and Surface Engineering, 2023
Amongst titanium alloys, the α+β Ti alloys are the ones with the best compromise between strength and fracture toughness. However, the applicability of α+β Ti alloys is limited by their higher cost compared to other structural metals.
L. Bolzoni, F. Yang, M. Jia
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

A Review of the State of Art of Fabrication Technologies of Titanium Aluminide (Ti-Al) Based on US Patents

Metals
This article evaluates the fabrication technologies of titanium aluminide (Ti-Al) and its practical applications by comparing it with the well-known Ti-Al binary phase diagram and US patents. Meanwhile, by analyzing and discussing the various patented Ti-
Shawdon Huang, Yu-Chien Lin, Ren-Jei Chung   +2 more
doaj   +1 more source

Machine-Learning-Based Composition Analysis of the Stability of V–Cr–Ti Alloys

Journal of Nuclear Engineering, 2023
Machine learning methods allow the prediction of material properties, potentially using only the elemental composition of a molecule or compound, without the knowledge of molecular or crystalline structures.
Katsuaki Tanabe
doaj   +1 more source