Results 21 to 30 of about 7,939 (195)

Ticlopidine-induced cholestasis [PDF]

, 1994
Objective: To investigate the effect of ticlopidine on bile secretion and liver ultrastructure in an attempt to reproduce in vitro ticlopidine-induced cholestatic syndrome in humans.
Paola Delia Guardia, Livio Capocaccia, Domenico Alvaro, Maurizio Ripani, RIGGIO, Oliviero, Caterina Peri, Adriano Bini, Alessandro Gigliozzi, GAUDIO, EUGENIO, Edoardo Pescarmona, Tiziana La Rosa   +10 more
core   +1 more source

Toxicity of clopidogrel and ticlopidine on human myeloid progenitor cells: importance of metabolites [PDF]

, 2012
Ticlopidine and clopidogrel are thienopyridine derivatives used for inhibition of platelet aggregation. Not only hepatotoxicity, but also bone marrow toxicity may limit their use.
Brecht, Karin, Maseneni, Swarna, Krähenbühl, Stephan, Donzelli, Massimiliano, Taegtmeyer, A. B., Taegtmeyer, Anne Barbara   +5 more
core   +1 more source

Sensitive Voltammetric Determination of Ticlopidine in Pharmaceuticals Employing a Multi-Walled Carbon Nanotubes Paste Electrode

Orbital: The Electronic Journal of Chemistry, 2016
A sensitive analytical procedure has been developed for the determination of ticlopidine using a multi-walled carbon nanotubes paste electrode (MWCNTsPE). Direct oxidation of analyte was observed by cyclic voltammetry as evidenced by the presence of well-
Igor Rebech, Jessica Scremin, César Ricardo Teixeira Tarley, Elen Romão Sartori   +3 more
doaj   +3 more sources

Highly productive and scalable approach to synthesize ticlopidine: A potent thienopyridine anti-platelet aggregation drug

Heliyon, 2020
Ticlopidine (trade name Ticlid), an acidic thienopyridine derivative, is an effective, well-known and long-acting inhibitor of platelet aggregation.
Muhammad Faisal, Quret ul Aein, Aamer Saeed, Amara Mumtaz, Fayaz Ali Larik   +4 more
doaj   +1 more source

Effects of Celecoxib and Etoricoxib on the Pharmacokinetics and Pharmacological Effects of Orally Administered Tramadol: A Randomised Controlled Trial. [PDF]

Basic Clin Pharmacol Toxicol
ABSTRACT Tramadol is a widely used analgesic whose bioactivation to O‐desmethyltramadol is primarily mediated by cytochrome P450 2D6 (CYP2D6). Genetic variability and drug–drug interactions affecting CYP2D6 may influence tramadol pharmacokinetics and pharmacological effects.
Saarikoski T, Saari TI, Backman JT, Niemi M, Neuvonen PJ, Olkkola KT, Laine K.   +6 more
europepmc   +2 more sources

Clopidogrel versus ticlopidine after intracoronary stent placement [PDF]

, 1999
OBJECTIVESThe study compared the safety and efficacy of ticlopidine with clopidogrel in patients receiving coronary stents.BACKGROUNDStent thrombosis is reduced when ticlopidine is administered with aspirin.
Malcolm R Bell, David R Holmes, Rihal, Charanjit S, Peter B Berger, Henry Ting, Garratt, Kirk, Charanjit S Rihal, Ting, Henry, Bellot, Victoria, Steve Melby, Victoria Bellot, LaVon Hammes, Diane Grill, Bell, Malcolm R, Melby, Steve, Berger, Peter B, Mathew, Verghese, Barsness, Gregory, Gregory Barsness, Holmes, David R, Grill, Diane, Kirk Garratt, Hammes, LaVon, Verghese Mathew   +23 more
core   +1 more source

Antiplatelet Effect of Ticlopidine After Coronary Stenting [PDF]

, 1997
Objectives. This study sought to investigate the contribution of ticlopidine to the inhibition of platelet activation after coronary stent placement.Background.
Timm Dickfeld, Rudolf Blasini, Walter, Hanna, Anne Wehinger, Meinrad Gawaz, Dickfeld, Timm, Neumann, Franz-Josef, Gawaz, Meinrad, Blasini, Rudolf, Albert Schömig, Schömig, Albert, Wehinger, Anne, Hanna Walter, Franz-Josef Neumann   +13 more
core   +1 more source

Ticlopidine-Induced Cholestatic Inflammatory Hepatitis: New Insights into Pathogenetic Mechanisms of Drug-Related Hepatotoxicity

European Journal of Inflammation, 2006
In immune-induced liver damage the reactive metabolites may covalently bind or alter liver proteins such as cytochrome P450 enzymes, which leads to activation of the immune system. Ticlopidine is an inhibitor of CYP2C19 human liver cytochrome.
I. Kraslova, L. Muchova, L. Vitek, A. Novotny, T. Svestka, R. Bruha   +5 more
doaj   +1 more source

Detecting Adverse Drug Events Through the Chronological Relationship Between the Medication Period and the Presence of Adverse Reactions From Electronic Medical Record Systems: Observational Study

JMIR Medical Informatics, 2021
BackgroundMedicines may cause various adverse reactions. An enormous amount of money and effort is spent investigating adverse drug events (ADEs) in clinical trials and postmarketing surveillance.
Kei Teramoto, Toshihiro Takeda, Naoki Mihara, Yoshie Shimai, Shirou Manabe, Shigeki Kuwata, Hiroshi Kondoh, Yasushi Matsumura   +7 more
doaj   +1 more source

Comparison of Clopidogrel and Ticlopidine/Ginkgo Biloba in Patients With Clopidogrel Resistance and Carotid Stenting

Frontiers in Neurology, 2019
Background and Purpose: Patients undergoing carotid artery stenting (CAS) who show low responsiveness to clopidogrel may have a higher risk of peri-procedural embolic events.
Jong-Won Chung, Suk Jae Kim, Jaechun Hwang, Mi Ji Lee, Jun Lee, Kyung-Yul Lee, Man-Seok Park, Sang Min Sung, Keon Ha Kim, Pyoung Jeon, Oh Young Bang   +10 more
doaj   +1 more source