Results 31 to 40 of about 8,373 (188)

Clinical pharmacokinetics of ticlopidine

, 1994
Platelets contribute significantly to arterial-occlusive thrombosis, one of the major causes of death and disease throughout the world. Consequently, inhibiting platelet function is a potentially important therapeutic goal.
Desager, Jean-Pierre
core   +1 more source

Drug Interaction between Ticlopidine and Cyclosporine [PDF]

, 2001
INTRODUCTIONCyclosporine is an immunosuppressant that is widely used for patients undergoing organ transplantation. Optimal long-term use of the drug entails careful monitoring of blood or plasma concentrations.1 The concurrent administration of other ...
Hollomby, David J., Newman, Jennifer, Iroaga, Uchenwa   +2 more
core   +1 more source

Antiplatelet drugs for secondary prevention in patients with ischemic stroke or transient ischemic attack: a systematic review and network meta-analysis

BMC Neurology, 2021
Background Antiplatelet drugs may prevent recurrent ischemic events after ischemic stroke but their relative effectiveness and harms still need to be clarified.
Cinzia Del Giovane, Giorgio B. Boncoraglio, Lorenza Bertù, Rita Banzi, Irene Tramacere   +4 more
doaj   +1 more source

Ticlopidine-induced cholestasis

, 1994
Objective: To investigate the effect of ticlopidine on bile secretion and liver ultrastructure in an attempt to reproduce in vitro ticlopidine-induced cholestatic syndrome in humans.
Paola Delia Guardia, Livio Capocaccia, Domenico Alvaro, Maurizio Ripani, RIGGIO, Oliviero, Caterina Peri, Adriano Bini, Alessandro Gigliozzi, GAUDIO, EUGENIO, Edoardo Pescarmona, Tiziana La Rosa   +10 more
core   +1 more source

Incidence of neutropenia in patients with ticlopidine/Ginkgo biloba extract combination drug for vascular events: A post-marketing cohort study.

PLoS ONE, 2019
Background and purposeThe ticlopidine/Ginkgo biloba ext. combination drug (Yuclid) is used as an antiplatelet agent for prevention of vascular events since its approval in 2008.
Han-Gil Jeong, Jae Sun Yoon, Juneyoung Lee, Hee-Joon Bae   +3 more
doaj   +1 more source

Toxicity of clopidogrel and ticlopidine on human myeloid progenitor cells: importance of metabolites

, 2012
Ticlopidine and clopidogrel are thienopyridine derivatives used for inhibition of platelet aggregation. Not only hepatotoxicity, but also bone marrow toxicity may limit their use.
Brecht, Karin, Maseneni, Swarna, Krähenbühl, Stephan, Donzelli, Massimiliano, Taegtmeyer, A. B., Taegtmeyer, Anne Barbara   +5 more
core   +1 more source

Is clopidogrel superior to aspirin in secondary prevention of vascular disease?

Current Controlled Trials in Cardiovascular Medicine, 2000
The cornerstone in clinical evidence of the relative efficacy of thienopyridines (clopidogrel, ticlopidine) versus aspirin in the secondary prevention of vascular disease is the Clopidogrel versus Aspirin in Patients at Risk of Ischaemic Events trial ...
Algra Ale, van Gijn Jan
doaj   +1 more source

The importance of early diagnosis and treatment of kaposiform hemangioendothelioma complicated by Kasabach-Merritt phenomenon

Dermatology Practical & Conceptual, 2015
Kaposiform hemangioendothelioma (KHE) is a locally aggressive vascular tumor that may be complicated by Kasabach-Merritt phenomenon (KMP), a profound thrombocytopenia resulting from platelet trapping within a vascular tumor, either KHE or tufted angioma (
Grecia V. Vivas-Colmenares, Gema L. Ramirez-Villar, Jose A. Matute de Cardenas, Jose Bernabeu-Wittel, Israel Fernandez-Pineda   +4 more
doaj   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis

Angewandte Chemie, Volume 138, Issue 25, 15 June 2026.
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley   +2 more sources