Ecotoxicology and Environmental Safety, 2023 Ticlopidine exerts its anti-platelet effects mainly by antagonizing platelet p2y12 receptors. Previously, a few studies have shown that ticlopidine can induce liver injury, but the exact mechanism of hepatotoxicity remains unclear.
Chuanming Lin, Liuyan Xin, Haiyan Wei
exaly +3 more sources
Overcoming Clopidogrel Resistance in Carotid Artery Stenting: Experience with Ticagrelor and Ticlopidine [PDF]
Clinics and PracticeObjectives: The goal of this study is to establish the incidence of high on-treatment platelet reactivity (HTPR) to aspirin and clopidogrel in patients undergoing carotid stenting and to evaluate the efficacy of ticagrelor and ticlopidine in patients ...
Pavol Vigláš +6 more
doaj +2 more sources
Lansoprazole‐Induced Microscopic Colitis Mimicking Anticancer Drug‐Related Diarrhea During Lenvatinib and Pembrolizumab Combination Therapy: A Case Report [PDF]
Clinical Case Reports, Volume 14, Issue 6, June 2026.ABSTRACT Persistent diarrhea during anticancer therapy may not be attributable to anticancer agents. Our patient presented with diarrhea during lenvatinib–pembrolizumab therapy, likely caused by lansoprazole‐induced microscopic colitis. Even when symptoms closely resemble anticancer drug or immune‐related colitis, drug‐induced colitis due to ...
Shinichi Maruyama +6 more
wiley +2 more sources
When Delirium Unmasks a Silent Myocardial Infarction [PDF]
Journal of the American Geriatrics Society, Volume 74, Issue 2, Page 623-625, February 2026.Abbreviations: hs‐TnT: high sensitivity Troponin T; STEMI: ST‐elevation myocardial infarction.
Eugenia Casali +10 more
wiley +2 more sources
Effects of Celecoxib and Etoricoxib on the Pharmacokinetics and Pharmacological Effects of Orally Administered Tramadol: A Randomised Controlled Trial [PDF]
Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 1, July 2026.ABSTRACT Tramadol is a widely used analgesic whose bioactivation to O‐desmethyltramadol is primarily mediated by cytochrome P450 2D6 (CYP2D6). Genetic variability and drug–drug interactions affecting CYP2D6 may influence tramadol pharmacokinetics and pharmacological effects.
Tuukka Saarikoski +6 more
wiley +2 more sources
A Critical Review of the Molecular and Clinical Effects of Cilostazol After Percutaneous Coronary Intervention [PDF]
Journal of Cardiovascular Development and DiseaseBackground: Restenosis after coronary stent implantation remains a major clinical challenge, especially in patients with diabetes, long lesions, or multiple stents.
Roberto Ferrari +1 more
doaj +2 more sources
Comprehensive Review of Antiplatelet Therapy in Secondary Prevention of Myocardial Infarction: Mechanisms, Clinical Evidence, and Future Directions [PDF]
Cardiovascular Therapeutics, Volume 2026, Issue 1, 2026.Atherosclerotic cardiovascular disease (ASCVD), particularly myocardial infarction (MI), is the leading cause of mortality and morbidity worldwide. The pathophysiology of MI involves atherosclerotic plaque rupture with thrombus formation, interrupting myocardial blood supply with subsequent myocardial necrosis.
May Thu Kyaw, Arkar Moe, Irfan Ahmad
wiley +2 more sources
Ecotoxicology and Environmental Safety, 2022 Ticlopidine has inhibitory effects on platelet aggregation via ADP (adenosine diphosphate), platelet release reaction and depolymerization. In clinical practice, it is commonly used to prevent heart, cerebrovascular and other thromboembolic diseases ...
Rong Xu +9 more
doaj +1 more source
Ticlopidine and Clopidogrel [PDF]
Circulation, 1999 Abstract —The thienopyridines ticlopidine and clopidogrel are inhibitors of platelet function in vivo. Their mode of action has not been defined, but it appears that they require conversion to as yet unidentified metabolites that are noncompetitive antagonists of the platelet ADP receptor. Inhibition
M J, Quinn, D J, Fitzgerald
openaire +2 more sources
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source