Results 51 to 60 of about 8,106 (209)

Standard Protocols for Characterising Primary and In Vitro‐Generated Human Hepatocytes

Journal of Cellular and Molecular Medicine, Volume 29, Issue 3, February 2025.
ABSTRACT Hepatocyte‐like cells (HLCs) derived from pluripotent stem cells (PSCs) or direct reprogramming are an unlimited source of human hepatocytes for biomedical applications. HLCs are used to model human diseases, develop precise drugs and establish groundbreaking regenerative cell‐based therapies.
Zahra Heydari, Roberto Gramignoli, Abbas Piryaei, Ensieh Zahmatkesh, Paria Pooyan, Homeyra Seydi, Andreas Nussler, Dagmara Szkolnicka, Hassan Rashidi, Mustapha Najimi, David C. Hay, Massoud Vosough   +11 more
wiley   +1 more source

Fibroelastoma of the mitral valve as a cause of transient ischemic stroke

Arquivos Brasileiros de Cardiologia, 2001
A 44-year-old woman had a transient ischemic stroke, fibroelastoma of the mitral valve being the source of the embolus. The patient evolved with neutropenia induced by ticlopidine after 10 days of treatment.
Alexandre Alessi, Roberto Gomes de Carvalho, Dalton Bertolin Précoma, Débora Fontoura, Luciano Rodrigo Oliveira, José Zanis Neto, Marcello Zapparoli   +6 more
doaj   +1 more source

Dual NHC/HAT‐Promoted Esterification to Access α‐Aryl Glycines

Advanced Synthesis &Catalysis, Volume 367, Issue 2, January 21, 2025.
Abstract α‐Aryl glycines are among the most important carbonyl compounds, particularly as nonproteinogenic α‐amino acids present in many pharmacophores. As such, many strategies have been developed to access this motif, but direct carboxylation methods remain underdeveloped.
Matthew J. McGill, Adam X. Wayment, Cullen R. Schull, Karl A. Scheidt   +3 more
wiley   +1 more source

AGRANULOCYTOSIS AND MACULOPAPULAR RASH AFTER TREATMENT WITH TICLOPIDINE – CASE REPORT

Zdravniški Vestnik, 2003
Background. Ticlopidine is one of inhibitors of platelet aggregation indicated for reducing the risk of thrombotic stroke in patients who have experienced thrombotic stroke, ischemic attacks, unstable angina pectoris, coronary artery stenting and ...
Janja Blatnik, Gorazd Lešničar, Branko Šibanc, Stella Cvitan, Harry Strokol   +4 more
doaj  

2-Chlorophenyl Zinc Bromide: A Convenient Nucleophile for the Mannich-Related Multicomponent Synthesis of Clopidogrel and Ticlopidine

Molecules, 2010
A methodological study devoted to the Mannich-like multicomponent synthesis of the antiplatelet agent (±)‑clopidogrel (7) and the ethyl ester analogue 6 is described.
Isabelle Aillaud, Caroline Haurena, Erwan Le Gall, Gino Ricci, Thierry Martens   +4 more
doaj   +1 more source

Acrocyanosis: The Least Known Acrosyndrome Revisited With a Dermatologic Perspective

Dermatology Research and Practice, Volume 2025, Issue 1, 2025.
Background: Acrocyanosis is a functional peripheral vascular disorder, currently categorized under the canopy of acrosyndromes, i.e., a group of clinically similar and significantly overlapping vascular disorders involving the acral skin. The disorder might be primary or secondary, depending on the cause.
Deniz Demircioğlu, Emel Öztürk Durmaz, Enzo Errichetti   +2 more
wiley   +1 more source

Effects of Ticlopidine or Ticlopidine Plus Aspirin on Platelet Aggregation and ATP Release in Normal Volunteers: Why Aspirin Improves Ticlopidine Antiplatelet Activity [PDF]

Clinical and Applied Thrombosis/Hemostasis, 1999
Aspirin and ticlopidine are used to prevent arterial thrombosis. In some clinical settings ticlopidine is administered with aspirin for improving antithrombotic effect. We adminis tered aspirin (100 mg/day), ticlopidine (500mg/day), or ticlo pidine and aspirin for 7 days to healthy volunteers.
Raul Altman, Claudio Gonzalez, Alejandra Scazziota, Jorge Rouvier   +3 more
openaire   +3 more sources

The seasonal distribution of immune thrombotic thrombocytopenic purpura is influenced by geography: Epidemiologic findings from a multi‐center analysis of 719 disease episodes

American Journal of Hematology, Volume 99, Issue 11, Page 2063-2074, November 2024.
Prior studies have suggested that immune thrombotic thrombocytopenic purpura (iTTP) may display seasonal variation; however, methodologic limitations and sample sizes have diminished the ability to perform a rigorous assessment. This 5‐year retrospective study assessed the epidemiology of iTTP and determined whether it displays a seasonal pattern ...
Jeremy W. Jacobs, Caroline G. Stanek, Garrett S. Booth, Argiris Symeonidis, Andrew W. Shih, Elizabeth S. Allen, Eleni Gavriilaki, Brenda J. Grossman, Katerina Pavenski, Amy Moorehead, Flora Peyvandi, Pasquale Agosti, Ilaria Mancini, Laura D. Stephens, Jay S. Raval, Maria Eva Mingot‐Castellano, Elizabeth P. Crowe, Laetitia Daou, Menaka Pai, Donald M. Arnold, Marisa B. Marques, Ryan Henrie, Tyler W. Smith, Gayatri Sreenivasan, Rance C. Siniard, Lisa R. Wallace, Chisa Yamada, Miriam Andrea Duque, Yanyun Wu, Thomas J. Harrington, Diana M. Byrnes, Aikaterini Bitsani, Amanda K. Davis, Danielle H. Robinson, Quentin Eichbaum, Cristina A. Figueroa Villalba, Justin E. Juskewitch, Georgia Kaiafa, Eleni Kapsali, Ellen Klapper, Ingrid Perez‐Alvarez, Monica S. Klein, Nikolaos Kotsiou, Chrysavgi Lalayanni, Evdokia Mandala, Fatima Aldarweesh, Rahaf Alkhateb, Lisandro Fortuny, Zois Mellios, Apostolia Papalexandri, Meredith G. Parsons, Annette J. Schlueter, Christopher A. Tormey, Cameron Wellard, Erica M. Wood, Shiyang Jia, Allison P. Wheeler, Amy A. Powers, Christopher B. Webb, Sean G. Yates, Raïda Bouzid, Paul Coppo, Evan M. Bloch, Brian D. Adkins   +63 more
wiley   +1 more source

Acute Iatrogenic Agranulocytosis: A Rare and Dire Case of an Adverse Drug Reaction to Be Aware

Case Reports in Hematology, 2020
Background. Iatrogenic agranulocytosis (IA), by nonchemotherapeutic drugs, is a rare adverse event, resulting in a neutrophil count under 0.5 × 109 cells/L with fever or other suggestive signs of infection. Methods.
Diogo André, Mónica Caldeira, Fabiana Gouveia, Rafael Nascimento, António Chaves, Maria Brazão   +5 more
doaj   +1 more source

Selective Inhibition of P2Y1 and P2Y12 Receptor Signal Pathways in Platelet Aggregation in Transgenic Cell Lines and Rats by Potassium 2‐(1‐Hydroxypentyl)‐Benzoate, Puerarin and Salvianolic Acid B

CNS Neuroscience &Therapeutics, Volume 30, Issue 11, November 2024.
Dl‐PHPB and puerarin inhibit the Gq‐PLC‐IP3‐Ca2+ signal transduction pathway, reduce IP3 and intracellular [Ca2+]i and decrease platelet aggregation via acting on P2Y1 receptor. However, salvianolic acid B, like ticagrelor, inhibits the Gi‐AC‐cAMP signal transduction pathway, enhances cAMP and decreases platelet aggregation via acting on P2Y12 ...
Yiying Li, Weiping Wang, Jie Cai, Nan Feng, Shaofeng Xu, Ling Wang, Xiaoliang Wang   +6 more
wiley   +1 more source