Results 181 to 190 of about 30,783 (205)

The emergence of clinical resistance to tigecycline

International Journal of Antimicrobial Agents, 2013
Tigecycline (TIG) exhibits broad-spectrum activity against many Gram-positive and Gram-negative pathogens. However, clinical resistance has emerged recently and has been detected following treatment with TIG. This observation suggests that long-term monotherapy may carry a high risk for TIG resistance.
Yan Sun, Yun Cai, Xu Liu
exaly   +3 more sources

Tigecycline–Rifampicin Restrains Resistance Development in Carbapenem-Resistant Klebsiella pneumoniae

ACS Infectious Diseases, 2023
The goal of this study was to clarify the synergistic antibacterial activity of the combination of tigecycline (TGC) and rifampicin (RIF). Additionally, the study sought to investigate the impact of this combination on the development of mutational resistance and to assess its efficacy in an in vivo model using Galleria mellonella.
Shiyi Shi, Mengxin Xu, Yining Zhao, Luozhu Feng, Qi Liu, Zhuocheng Yao, Yao Sun, Tieli Zhou, Jianzhong Ye   +8 more
openaire   +2 more sources

Development mechanism of resistant population post-exposure to tigecycline in tigecycline-heteroresistant Acinetobacter baumannii strain

International Journal of Antimicrobial Agents, 2023
Tigecycline heteroresistance is highly prevalent in Acinetobacter baumannii clinical isolates, reducing the efficacy of tigecycline treatment. This study investigated the population dynamics of A. baumannii with tigecycline heteroresistance to determine the origin of resistance that occurs over time after antibiotic exposure.
Jeongwoo Jo, Wonbeom Park, Dae-Hyuk Kweon, Kwan Soo Ko   +3 more
openaire   +2 more sources

RshA mutations contributing to tigecycline resistance in Mycobacteroides abscessus

Journal of Medical Microbiology, 2022
Tigecycline is an important rescue antibiotic for many bacterial infections. In Mycobacteroides abscessus , tigecycline resistance has been associated with dysregulated stress response caused by aberrations in the interaction of the SigH and RshA factors.
Kar Men Aw, Hien Fuh Ng, Col Lin Lee, Thaw Zin, Yun Fong Ngeow   +4 more
openaire   +2 more sources

Tigecycline therapy in pediatric patients with multidrug resistant bacteremia

Enfermedades Infecciosas y Microbiología Clínica, 2020
Multidrug resistance among bacteria increases the need for new therapeutic options. Tigecycline is one candidate drug, due to property of a wider anti-bacterial spectrum to multi-drug resistant (MDR) pathogens. However, it has still not been approved for use in pediatric patients.In this study the effectiveness and safety of tigecycline in children was
Gulhan, Belgin, Senel, EMRAH, Unal, Sevim, Tezer, Hasan, Demirtas, Gokhan, Gonulal, Deniz, Guney, Dogus, Kanik-Yuksek, Saliha, Ozkaya-Parlakay, Aslinur   +8 more
openaire   +3 more sources

Rapid Development of Acinetobacter baumannii Resistance to Tigecycline

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2007
A 53‐year‐old woman experienced a multidrug‐resistant (MDR) Acinetobacter baumannii urinary tract infection 5 months after undergoing kidney and liver transplantation. The tigecycline minimum inhibitory concentration (MIC) for her A. baumannii isolate was 1.5 μg/ml; the patient received 2 weeks of therapy with intravenous tigecycline as a 100‐mg ...
Gail E, Reid, Shellee A, Grim, Christine A, Aldeza, William M, Janda, Nina M, Clark   +4 more
openaire   +2 more sources

[Resistance of Acinetobacter baumannii to Tigecycline].

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2019
To determine the impact of long-term use of antibiotics and ultraviolet radiation on the resistance of Acinetobacter baumannii to tigecycline and the viability of tigecycline-resistant Acinetobacter baumannii .Three strains of tigecycline sensitive Acinetobacter baumannii were selected. Tigecycline resistance was induced through multi-step method or by
Jun-Yan, Qu, Xiao-Ju, Ü
openaire   +1 more source

Carbapenem-resistantKlebsiella pneumoniaesepsis in corticosteroid receipt mice: tigecycline or colistin monotherapy versus tigecycline/colistin combination

Journal of Chemotherapy, 2013
This study compared the effect of monotherapy of colistin, tigecycline, and their combination in sepsis model of mice. OXA-48 producing Carbapenem-resistant Klebsiella pneumoniae (CRKP) strain was used in Balb/c mice. The mice were divided into competent and Methylprednisolone acetate (MPA)-treated groups.
Elmali, Ferhan, Demiraslan, Hayati, Metan, Gökhan, Alp, Emine, Dinç, Gökçen, Ahmed, Salman Shaheer, Doğanay, Mehmet   +6 more
openaire   +4 more sources

In-vitro activities of imipenem–colistin, imipenem–tigecycline, and tigecycline–colistin combinations against carbapenem-resistant Enterobacteriaceae*

Journal of Chemotherapy, 2018
The aim of the study is to determine in-vitro effects of imipenem-tigecycline, imipenem-colistin and tigecycline-colistin against carbapenem-resistant Enterobacteriaceae (CRE) isolates. A total of 25 CRE isolates were included to the study. The minimum inhibition concentrations of imipenem, colistin-sulphate and tigecycline were determined with broth ...
Devrim Dundar, Zehra Duymaz, Serpil Genc, Doganhan Kadir Er, Arzu İrvem, Neslisah Kandemir   +5 more
openaire   +3 more sources

Tigecycline: The answer to beta-lactam and fluoroquinolone resistance?

Journal of Infection, 2006
Patients with serious bacterial infections such as intra-abdominal infections and complicated skin and soft tissue infections are often treated empirically because a delay in appropriate initial antimicrobial therapy has been shown to significantly increase morbidity and mortality.
openaire   +2 more sources