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Small RNA-regulated expression of efflux pump affects tigecycline resistance and heteroresistance in clinical isolates of Klebsiella pneumoniae.

Microbiology Research
Tigecycline and the newly Food and Drug Administration-approved tetracyclines, including eravacycline and omadacycline, are regarded as last-resort treatments for multidrug-resistant Enterobacterales.
Yuqiao Han   +10 more
semanticscholar   +1 more source

Tigecycline: The answer to beta-lactam and fluoroquinolone resistance?

Journal of Infection, 2006
Patients with serious bacterial infections such as intra-abdominal infections and complicated skin and soft tissue infections are often treated empirically because a delay in appropriate initial antimicrobial therapy has been shown to significantly increase morbidity and mortality.
openaire   +2 more sources

Tigecycline in the Era of Antibiotic Resistance: A Current Review

Current Medicinal Chemistry
Abstract: Tigecycline (TIG) is a broad-spectrum antibiotic of the tetracycline class that evades the resistance mechanisms common to first- and second-generation tetracyclines and is effective against Gram-negative and Gram-positive bacteria, as well as intracellular bacteria.
Jessica L. Ortega-Balleza   +5 more
openaire   +2 more sources

Rapid Development of Acinetobacter baumannii Resistance to Tigecycline

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2007
A 53‐year‐old woman experienced a multidrug‐resistant (MDR) Acinetobacter baumannii urinary tract infection 5 months after undergoing kidney and liver transplantation. The tigecycline minimum inhibitory concentration (MIC) for her A. baumannii isolate was 1.5 μg/ml; the patient received 2 weeks of therapy with intravenous tigecycline as a 100‐mg ...
Gail E, Reid   +4 more
openaire   +2 more sources

[Resistance of Acinetobacter baumannii to Tigecycline].

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2019
To determine the impact of long-term use of antibiotics and ultraviolet radiation on the resistance of Acinetobacter baumannii to tigecycline and the viability of tigecycline-resistant Acinetobacter baumannii .Three strains of tigecycline sensitive Acinetobacter baumannii were selected. Tigecycline resistance was induced through multi-step method or by
Jun-Yan, Qu, Xiao-Ju, Ü
openaire   +1 more source

Emerging High‐Level Tigecycline Resistance: Novel Tetracycline Destructases Spread via the Mobile Tet(X)

Bioessays, 2020
Antibiotic resistance in bacteria has become a great threat to global public health. Tigecycline is a next‐generation tetracycline that is the final line of defense against severe infections by pan‐drug‐resistant bacterial pathogens.
Liang-xing Fang   +7 more
semanticscholar   +1 more source

Oritavancin and Tigecycline: Investigational Antimicrobials for Multidrug‐Resistant Bacteria

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2004
The advent of multidrug‐resistant gram‐positive aerobes such as Staphylococcus aureus, Streptococcus pneumoniae , and the enterococci, which are resistant to β‐lactams, vancomycin, and a host of other commonly used antimicrobials, has complicated our approach to antibiotic therapy.
openaire   +2 more sources

A Nosocomial Cluster of Tigecycline- and Vancomycin-Resistant Enterococcus faecium Isolates and the Impact of rpsJ and tet(M) Mutations on Tigecycline Resistance.

Microbial drug resistance (Larchmont, N.Y.), 2021
Tigecycline-resistant enterococci are only rarely detected worldwide. In 2017, the National Reference Centre for Staphylococci and Enterococci noticed a nosocomial cluster of tigecycline- and vancomycin-resistant Enterococcus faecium (TVRE) in a hospital of tertiary care in Northern Germany. Nineteen E.
Jennifer K, Bender   +3 more
openaire   +1 more source

Emergence of plasmid-mediated tigecycline resistance tet(X4) gene in Escherichia coli isolated from poultry, food and the environment in South Asia.

Science of the Total Environment, 2021
M. Mohsin   +6 more
semanticscholar   +1 more source

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