Results 151 to 160 of about 5,707,439 (181)

Overexpression of AdeABC efflux pump associated with tigecycline resistance in clinical Acinetobacter nosocomialis isolates

Clinical Microbiology and Infection, 2019
[[abstract]]Objectives: Tigecycline non-susceptible Acinetobacter nosocomialis (TNAN) has been discovered in clinical isolates. The resistance-nodulation-cell division (RND)-type efflux system plays a major role in tigecycline non-susceptible ...
Jun-Ren Sun, Yenyu Chang, T -L Chen
exaly   +2 more sources

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Development mechanism of resistant population post-exposure to tigecycline in tigecycline-heteroresistant Acinetobacter baumannii strain

International Journal of Antimicrobial Agents, 2023
Tigecycline heteroresistance is highly prevalent in Acinetobacter baumannii clinical isolates, reducing the efficacy of tigecycline treatment. This study investigated the population dynamics of A. baumannii with tigecycline heteroresistance to determine the origin of resistance that occurs over time after antibiotic exposure.
Jeongwoo Jo, Wonbeom Park, Dae-Hyuk Kweon, Kwan Soo Ko   +3 more
openaire   +2 more sources

Tigecycline-resistance mechanisms and biological characteristics of drug-resistant Salmonella Typhimurium strains in vitro.

Veterinary Microbiology, 2023
Increased drug resistance of Gram-negative bacteria to tetracycline caused by the unreasonable overuse of tigecycline has attracted extensive attention to reveal potential mechanisms.
Lin Li, Longbo Wang, Shuo Yang, Yanfang Zhang, Yiming Gao, Qianyu Ji, Linran Fu, Qiling Wei, Feifei Sun, Shaoqi Qu   +9 more
semanticscholar   +1 more source

Abundance of tigecycline resistance genes and association with antibiotic residues in Chinese livestock farms.

Journal of Hazardous Materials, 2021
The discovery of plasmid-mediated tet(X) variants and efflux pump gene tmexCD1-toprJ1 conferring bacteria resistance to tigecycline has compromised glycylcycline as the last line of defense against infection, which poses serious threat to public health ...
Yulin Fu, Yiqiang Chen, Dejun Liu, Dawei Yang, Zhihai Liu, Yingyu Wang, Jiayi Wang, Xueyang Wang, Xiangyue Xu, Xing-Hua Li, Junjia He, Junyao Jiang, W. Zhai, Lingli Huang, Tao He, X. Xia, C. Cai, Yang Wang, Haiyang Jiang   +18 more
semanticscholar   +1 more source

Establishing the role of tigecycline in an era of antimicrobial resistance

Expert Review of Anti-infective Therapy, 2008
Tigecycline is a glycylcycline antibacterial agent derived from minocycline with a broad spectrum of activity. Like tetracycline agents, it inhibits bacterial protein synthesis but is able to bind to target sites with higher affinity and overcome tetracycline-resistance mechanisms due to structural modifications.
Jason J, Schafer, Debra A, Goff
openaire   +2 more sources

Distribution and spread of tigecycline resistance gene tet(X4) in Escherichia coli from different sources

Frontiers in Cellular and Infection Microbiology
Tigecycline serves as a last-resort antimicrobial agent against severe infections caused by multidrug-resistant bacteria. Tet(X) and its numerous variants encoding flavin-dependent monooxygenase can confer resistance to tigecycline, with tet(X4) being ...
Xin Fan, Yue Jiang, Han Wu, Jie Liu, Qing-Yun Gu, Zhenyuan Wang, Lin Sun, Xinan Jiao, Qiuchun Li, Jing Wang   +9 more
exaly   +2 more sources

Tigecycline therapy in pediatric patients with multidrug resistant bacteremia

Enfermedades Infecciosas y Microbiología Clínica, 2020
Multidrug resistance among bacteria increases the need for new therapeutic options. Tigecycline is one candidate drug, due to property of a wider anti-bacterial spectrum to multi-drug resistant (MDR) pathogens. However, it has still not been approved for use in pediatric patients.In this study the effectiveness and safety of tigecycline in children was
Gulhan, Belgin, Senel, EMRAH, Unal, Sevim, Tezer, Hasan, Demirtas, Gokhan, Gonulal, Deniz, Guney, Dogus, Kanik-Yuksek, Saliha, Ozkaya-Parlakay, Aslinur   +8 more
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The Poultry Pathogen Riemerella anatipestifer Appears as a Reservoir for Tet(X) Tigecycline Resistance.

Environmental Microbiology, 2021
The transferability of bacterial resistance to tigecycline, the 'last-resort' antibiotic, is an emerging challenge of global health concern. The plasmid-borne tet(X) that encodes a flavin-dependent monooxygenase represents a new mechanism for tigecycline
Zeeshan Umar, Qiwei Chen, Biao Tang, Yongchang Xu, Jinzi Wang, Huimin Zhang, Kai Ji, Xu Jia, Youjun Feng   +8 more
semanticscholar   +1 more source

Emergence of two novel tmexCD-toprJ subtypes mediating tigecycline resistance in the megaplasmids from Pseudomonas putida.

Microbiology Research
The widespread antimicrobial resistance (AMR) problem poses a serious health threat, leaving few drug choices, including tigecycline, to treat multidrug resistance pathogens.
Chengzhen Wang, Xun Gao, Xiao-Yu Zhang, Chao Yue, Luchao Lv, Litao Lu, Jian-Hua Liu   +6 more
semanticscholar   +1 more source

Prevalence of RND efflux pump regulator variants associated with tigecycline resistance in carbapenem-resistant Acinetobacter baumannii from a worldwide survey.

Journal of Antimicrobial Chemotherapy, 2021
OBJECTIVES To determine the most common tigecycline resistance mechanisms in carbapenem-resistant Acinetobacter baumannii isolates obtained during the global Tigecycline Evaluation Surveillance Trial (TEST).
K. Lucassen, C. Müller, J. Wille, K. Xanthopoulou, M. Hackel, H. Seifert, P. Higgins   +6 more
semanticscholar   +1 more source