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The Mechanism of Tigecycline Resistance in Acinetobacter baumannii Revealed by Proteomic and Genomic Analysis

International Journal of Molecular Sciences, 2023
The mechanism of tigecycline resistance in A. baumannii remains largely unclear. In this study, we selected a tigecycline-resistant and a tigecycline-susceptible strain from a tigecycline-susceptible and a resistant strain, respectively.
Di Xiao, Qinghua Zou
exaly   +3 more sources

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The emergence of clinical resistance to tigecycline

International Journal of Antimicrobial Agents, 2013
Tigecycline (TIG) exhibits broad-spectrum activity against many Gram-positive and Gram-negative pathogens. However, clinical resistance has emerged recently and has been detected following treatment with TIG. This observation suggests that long-term monotherapy may carry a high risk for TIG resistance.
Yun Cai, Rui Wang, Xu Liu
exaly   +3 more sources

RshA mutations contributing to tigecycline resistance in Mycobacteroides abscessus

Journal of Medical Microbiology, 2022
Tigecycline is an important rescue antibiotic for many bacterial infections. In Mycobacteroides abscessus , tigecycline resistance has been associated with dysregulated stress response caused by aberrations in the interaction of the SigH and RshA factors.
Kar Men Aw, Hien Fuh Ng, Col Lin Lee, Thaw Zin, Yun Fong Ngeow   +4 more
openaire   +3 more sources

A Potential Nontraditional Approach To Combat tmexCD1-toprJ1- Mediated Tigecycline Resistance: Melatonin as a Synergistic Adjuvant of Tigecycline

Antimicrobial Agents and Chemotherapy, 2023
The emergence of TMexCD1-TOprJ1, a novel transferable resistance-nodulation-division (RND)-type efflux pump conferring resistance to tigecycline, is now a serious public health issue in the world.
Jinhu Huang, Xiaoming Wang, Liping Wang   +2 more
exaly   +2 more sources

Mechanisms of tigecycline resistance in Gram-negative bacteria: A narrative review

Engineering Microbiology
Tigecycline serves as a critical "final-resort" antibiotic for treating bacterial infections caused by multidrug-resistant bacteria for which treatment options are severely limited.
Hai Xu, Xiuhua Pang, Chengzhang Fu
exaly   +2 more sources

Tigecycline antibacterial activity, clinical effectiveness, and mechanisms and epidemiology of resistance: narrative review [PDF]

European Journal of Clinical Microbiology and Infectious Diseases, 2021
Tigecycline is unique glycylcycline class of semisynthetic antimicrobial agents developed for the treatment of polymicrobial infections caused by multidrug-resistant Gram-positive and Gram-negative pathogens.
Farajolah Maleki, Ebrahim Kouhsari, Sajad Yaghoubi   +2 more
exaly   +2 more sources

Curcumin reverses high-level tigecycline resistance mediated by different mechanisms in Gram-negative bacteria

Phytomedicine
BACKGROUND Tigecycline is one of the few effective treatments for multidrug-resistant bacteria. However, the recent emergence and spread of high-level tigecycline resistance in Enterobacteriaceae have significantly limited its clinical use.
Yajun Zhai
exaly   +2 more sources

Emergence of high-level tigecycline resistance due to the amplification of a tet(A) gene variant in clinical carbapenem-resistant Klebsiella pneumoniae.

Clinical Microbiology and Infection, 2023
OBJECTIVE To investigate the prevalence of a tet(A) gene variant and its role in developing high-level tigecycline resistance among carbapenem-resistant Klebsiella pneumoniae (CRKP) clinical isolates.
Runhao Yu, Longyu Li, C. Zou, Zheng Chen, S. Schwarz, Sheng Chen, Chunyan Xu, Hong Yao, Xiang-Dang Du   +8 more
semanticscholar   +1 more source

The tigecycline resistance gene tetX has an expensive fitness cost based on increased outer membrane permeability and metabolic burden in Escherichia coli.

Journal of Hazardous Materials, 2023
Livestock-derived tetX-positive Escherichia coli with tigecycline resistance poses a serious risk to public health. Fitness costs, antibiotic residues, and other tetracycline resistance genes (TRGs) are fundamental in determining the spread of tetX in ...
Tao Chen, Min Zhao, Xiaoyue Tang, Wenyan Wei, Xin Wen, Shichen Zhou, Baohua Ma, Yong-de Zou, Na Zhang, J. Mi, Yan Wang, Xin-Di Liao, Yinbao Wu   +12 more
semanticscholar   +1 more source

Characterization of a Novel Tigecycline Resistance Gene tet(X22) and its Coexistence with blaNDM-1 in a Pseudomonas caeni Isolate.

International Journal of Antimicrobial Agents, 2023
The emergence of pathogens resistant to both tigecycline and carbapenem poses a threat to public health globally. Continuous emergence of novel tet(X) variants accelerates the tigecycline resistance crisis.
Xiaoyu Lu, Lifei Zhang, Kai Peng, Qiaojun Wang, Ruoqi Liu, Zhiqiang Wang, Ruichao Li   +6 more
semanticscholar   +1 more source