Results 101 to 110 of about 441,106 (295)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Polarization Möbius strip at the tight focus of a generalized Poincaré beam

Компьютерная оптика
Based on the Richards-Wolf formalism, we investigate tight focusing of a generalized Poincaré beam. Analytical expressions are derived for all components of the electric field strength vector in the focal plane.
V.V. Kotlyar, A.A. Kovalev, A.M. Telegin
doaj   +1 more source

Filament-induced laser machining (FILM) [PDF]

, 2018
Laser filamentation provides high intensity plasma strings of micrometric diameters and lengths of tens of centimeters. We demonstrate that these filaments can be used for remotely drilling and cutting metals and biological materials such as flesh and ...
Kiselev, D., Woeste, L., Wolf, J.-P
core  

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Dust and Ionized Gas Association in E/S0 Galaxies with Dust Lanes: Clues to their Origin

, 2012
We present results from an on-going programme to study the dust and ionized gas in E/S0 galaxies with dust lanes. Our data, together with results from previous studies of E/S0 galaxies, are used to demonstrate the tight relationship between these two ...
Alexei Kniazev, Annibali, Athey, Bendo, Bertola, Bianchi, Boroson, Boselli, Bregman, Caon, Cappellari, Casuso, Clemens, Combes, da Cunha, Davis, de Jong, de Zeeuw, Dewangan, Diehl, Draine, Draine, Dwek, Ebneter, Fabian, Ferrari, Ferrari, Finkelman, Finkelman, Finkelman, Forbes, Garcia, Geller, Genzel, Goudfrooij, Goudfrooij, Goudfrooij, Goudfrooij, Gregorini, Guillard, Hawarden, Hildebrand, Huchra, Ido Finkelman, José G. Funes, Kainulainen, Kaneda, Kaneda, Kaneda, Kauffmann, Knapp, Kormendy, Krajnović, Krajnović, Krips, Krips, Landolt, Leeuw, Leeuw, Leeuw, Li, Macchetto, Madden, Martel, Mathews, Moellenhoff, Muñoz-Mateos, Noah Brosch, Oosterloo, Oosterloo, Osterbrock, Pahre, Panuzzo, Patil, Petri Väisänen, Quillen, Rampazzo, Sage, Sahu, Sansom, Sarzi, Sarzi, Serra, Sparks, Sparks, Sudhanshu Barway, Tago, Tal, Tang, Temi, Temi, Tran, Trinchieri, van Dokkum, van Dokkum, van Dokkum, Véron-Cetty, Walter, Wang, Wiklind, Xilouris, Young, Young   +102 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source