Results 81 to 90 of about 68,903 (215)

The effect of linearly polarized chirped laser pulses on the radiation characteristics of tightly focused nonlinear Thomson scattering

Frontiers in Physics
We numerically investigate nonlinear Thomson scattering from an initially stationary electron driven by a finite-waist, linearly polarized Gaussian pulse with quadratic spectral phase.
Jihong Wang, Zi Wang, Jiachen Li, Youwei Tian   +3 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Spin-orbit conversion at the sharp focus of a circularly polarized light beam

Компьютерная оптика
It is known that when tightly focusing a circularly polarized optical vortex, spin-to-orbital angular momentum conversion occurs. It is usually said that the longitudinal component of the spin angular momentum (SAM) vector is transformed into the ...
V.V. Kotlyar, A.A. Kovalev, A.G. Nalimov, A.M. Telegin, S.S. Stafeev   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Spin and orbital Hall effects in the tight focus of coaxial superposition of two cylindrical vector beams of different-parity orders

Компьютерная оптика
We study tight focusing of coaxial superposition of two cylindrical vector beams (CVB) of different orders. In the initial plane, the polarization singularity index of such superposition equals the half-sum of the orders of the two constituent CVBs. Such
V.V. Kotlyar, A.A. Kovalev, S.S. Stafeev, A.M. Telegin   +3 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Focusing a cylindrical vector beam and the Hall effect

Компьютерная оптика
Polarization of a higher-order cylindrical vector beam (CVB) is known to be locally linear. The higher the beam order, the larger number of full circles the local linear polarization vector makes around the optical axis.
V.V. Kotlyar, S.S. Stafeev , A.A. Kovalev, V.D. Zaitsev   +3 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source